AutismKB 2.0

Annotation Detail for NQO1


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Basic Information Top
Gene Symbol:NQO1 ( DHQU,DIA4,DTD,NMOR1,NMORI,QR1 )
Gene Full Name: NAD(P)H dehydrogenase, quinone 1
Band: 16q22.1
Quick LinksEntrez ID:1728; OMIM: 125860; Uniprot ID:NQO1_HUMAN; ENSEMBL ID: ENSG00000181019; HGNC ID: 2874
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst3 / 6231948
fetus12 / 56401221
neonate25 / 31097803
infant0 / 236200 
juvenile11 / 55556197
adult284 / 1939121146
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma12 / 17475686
breast (mammary gland) tumor14 / 94178148
cervical tumor7 / 34366203
chondrosarcoma13 / 82823156
colorectal tumor53 / 114246463
esophageal tumor10 / 17290578
gastrointestinal tumor70 / 119369586
germ cell tumor20 / 26384575
glioma9 / 10688384
head and neck tumor36 / 136302264
kidney tumor11 / 68959159
leukemia2 / 9584220
liver tumor42 / 96359435
lung tumor84 / 103127814
lymphoma1 / 7175513
non-neoplasia28 / 97250287
normal322 / 336030795
ovarian tumor2 / 7668226
pancreatic tumor14 / 104616133
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer41 / 102680399
retinoblastoma0 / 463560 
skin tumor26 / 124949208
soft tissue/muscle tissue tumor10 / 12519179
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland5 / 33197150
ascites32 / 40015799
bladder17 / 29757571
blood2 / 12347816
bone10 / 71655139
bone marrow3 / 4880161
brain59 / 110098953
cervix7 / 48171145
connective tissue28 / 149255187
ear0 / 162120 
embryonic tissue14 / 21572264
esophagus10 / 20209494
eye49 / 211054232
heart3 / 8962633
intestine60 / 234472255
kidney56 / 211777264
larynx1 / 2414541
liver66 / 207743317
lung99 / 336974293
lymph1 / 4427022
lymph node11 / 91610120
mammary gland19 / 153271123
mouth34 / 67052507
muscle2 / 10771518
nerve0 / 157680 
ovary4 / 10205139
pancreas24 / 214812111
parathyroid1 / 2053948
pharynx5 / 41328120
pituitary gland2 / 16585120
placenta11 / 28082539
prostate44 / 189345232
salivary gland0 / 201550 
skin96 / 210574455
spleen0 / 539520 
stomach44 / 96619455
testis6 / 33044218
thymus0 / 811310 
thyroid3 / 4747363
tonsil0 / 169990 
trachea19 / 52413362
umbilical cord3 / 13680219
uterus21 / 23287890
vascular20 / 51780386
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201468_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts11.3
Adipocyte108.95
AdrenalCortex14.1
Adrenalgland11.35
Amygdala9.6
Appendix13.55
AtrioventricularNode10.4
BDCA4+_DentriticCells9.5
Bonemarrow9.55
BronchialEpithelialCells84.3
CD105+_Endothelial9.25
CD14+_Monocytes9.9
CD19+_BCells(neg._sel.)9.7
CD33+_Myeloid11.5
CD34+9.95
CD4+_Tcells9.6
CD56+_NKCells10.7
CD71+_EarlyErythroid8.9
CD8+_Tcells7.6
CardiacMyocytes61.7
Caudatenucleus10.7
Cerebellum7.85
CerebellumPeduncles10.75
CiliaryGanglion7.25
CingulateCortex10.65
Colorectaladenocarcinoma54.15
DorsalRootGanglion9.9
FetalThyroid37.7
Fetalbrain9.25
Fetalliver8.2
Fetallung7.8
GlobusPallidus7.7
Heart12.95
Hypothalamus12.65
Kidney12.1
Leukemia_chronicMyelogenousK-5628.45
Leukemia_promyelocytic-HL-608.15
Leukemialymphoblastic(MOLT-4)7.3
Liver12.95
Lung13
Lymphnode8.05
Lymphoma_burkitts(Daudi)12.35
Lymphoma_burkitts(Raji)14
MedullaOblongata8.8
OccipitalLobe9.85
OlfactoryBulb9.8
Ovary7.05
Pancreas21.35
PancreaticIslet10.65
ParietalLobe10.95
Pituitary10.95
Placenta9.55
Pons9.2
PrefrontalCortex15.35
Prostate11.45
Salivarygland12.65
SkeletalMuscle15.05
Skin8.95
SmoothMuscle157.85
Spinalcord13.65
SubthalamicNucleus9.1
SuperiorCervicalGanglion17.25
TemporalLobe9.05
Testis8.2
TestisGermCell7.8
TestisIntersitial8.05
TestisLeydigCell11.55
TestisSeminiferousTubule8.25
Thalamus13.9
Thymus7.25
Thyroid39
Tongue18.65
Tonsil9.45
Trachea26.6
TrigeminalGanglion10.55
Uterus7.55
UterusCorpus9.6
WholeBlood10.45
Wholebrain8.25
colon53.05
pineal_day21.64
pineal_night25.44
retina26.45
small_intestine21.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16377_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.57 ± 0.43
Basal Forebrain4.41 ± 0.63
Basal Part of Pons4.89 ± 0.46
Cerebellar Cortex4.02 ± 0.39
Cerebellar Nuclei4.81 ± 0.4
Claustrum3.43 ± 0.77
Epithalamus5.44 ± 0.73
Frontal Lobe4.64 ± 0.62
Globus Pallidus5.14 ± 0.81
Hypothalamus4.91 ± 0.7
Insula4.76 ± 0.55
Limbic Lobe4.33 ± 0.75
Mesencephalon4.79 ± 0.73
Myelencephalon4.73 ± 0.72
Occipital Lobe4.24 ± 0.55
Parietal Lobe4.66 ± 0.69
Pontine Tegmentum4.72 ± 0.6
Striatum5.89 ± 0.41
Subthalamus4.79 ± 0.71
Temporal Lobe4.89 ± 0.55
Thalamus4.99 ± 0.5
White Matter4.56 ± 0.44
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Nqo1CBCerebellum40.91
81.03
Nqo1CTXCerebral cortex100
100
Nqo1HIPHippocampal region100
100
Nqo1HPFHippocampal formation100
100
Nqo1HYHypothalamus57.11
60.79
Nqo1LSXLateral septal complex100
100
Nqo1MBMidbrain61.77
70.55
Nqo1MYMedulla65.53
95.74
Nqo1OLFOlfactory bulb100
100
Nqo1PPons46.8
61.64
Nqo1PALPallidum76.05
95.48
Nqo1RHPRetrohippocampal region100
100
Nqo1sAMYStriatum-like amygdalar nuclei90.41
100
Nqo1STRStriatum100
100
Nqo1STRdStriatum dorsal region100
100
Nqo1STRvStriatum ventral region100
100
Nqo1THThalamus82.61
91.34
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
NQO1_HUMAN_119 20 119 138 VFIGEFAYTYAAMYDKGPFR PRIDE
NQO1_HUMAN_15 8 15 22 TSFNYAMK PRIDE
NQO1_HUMAN_192 10 192 201 SIGHTPADAR PRIDE
NQO1_HUMAN_201 8 201 208 IQILEGWK PRIDE
NQO1_HUMAN_201 9 201 209 IQILEGWKK PRIDE
NQO1_HUMAN_251 11 251 261 FGLSVGHHLGK PRIDE
NQO1_HUMAN_32 21 32 52 KGWEVVESDLYAMNFNPIISR PRIDE
NQO1_HUMAN_4 11 4 14 RALIVLAHSER PRIDE
NQO1_HUMAN_43 11 43 53 YAMNFNPIISR PRIDE
NQO1_HUMAN_5 10 5 14 ALIVLAHSER PRIDE
NQO1_HUMAN_59 18 59 76 LKDPANFQYPAESVLAYK PRIDE
NQO1_HUMAN_59 31 59 89 LKDPANFQYPAESVLAYKEGHLSPDIVAEQK PRIDE
NQO1_HUMAN_77 13 77 89 EGHLSPDIVAEQK PRIDE
PAp00033460 13 78 90 EGHLSPDIVAEQK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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