AutismKB 2.0

Annotation Detail for AFP


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Basic Information Top
Gene Symbol:AFP ( FETA,HPAFP )
Gene Full Name: alpha-fetoprotein
Band: 4q13.3
Quick LinksEntrez ID:174; OMIM: 104150; Uniprot ID:FETA_HUMAN; ENSEMBL ID: ENSG00000081051; HGNC ID: 317
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst2 / 6231932
fetus654 / 5640121159
neonate0 / 310970 
infant0 / 236200 
juvenile44 / 55556791
adult64 / 193912133
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor65 / 263845246
glioma1 / 1068839
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia16 / 95842166
liver tumor129 / 963591338
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal693 / 3360307206
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood16 / 123478129
bone0 / 716550 
bone marrow0 / 488010 
brain1 / 11009890 
cervix0 / 481710 
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue53 / 215722245
esophagus0 / 202090 
eye0 / 2110540 
heart247 / 896262755
intestine1 / 2344724
kidney23 / 211777108
larynx0 / 241450 
liver220 / 2077431059
lung10 / 33697429
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta14 / 28082549
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen25 / 53952463
stomach0 / 966190 
testis0 / 3304420 
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204694_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.75
Adipocyte3.8
AdrenalCortex4.15
Adrenalgland3.3
Amygdala4.1
Appendix3.9
AtrioventricularNode3.05
BDCA4+_DentriticCells4.25
Bonemarrow3.9
BronchialEpithelialCells3.8
CD105+_Endothelial3.9
CD14+_Monocytes4.15
CD19+_BCells(neg._sel.)4.15
CD33+_Myeloid5
CD34+4.9
CD4+_Tcells4.15
CD56+_NKCells4.6
CD71+_EarlyErythroid3.65
CD8+_Tcells3.7
CardiacMyocytes5.25
Caudatenucleus3.5
Cerebellum3.15
CerebellumPeduncles4.45
CiliaryGanglion2.8
CingulateCortex4
Colorectaladenocarcinoma3.9
DorsalRootGanglion3
FetalThyroid3.8
Fetalbrain3.85
Fetalliver8182.45
Fetallung347.7
GlobusPallidus2.85
Heart5.15
Hypothalamus4.2
Kidney3.2
Leukemia_chronicMyelogenousK-5623.5
Leukemia_promyelocytic-HL-603.4
Leukemialymphoblastic(MOLT-4)3.1
Liver5.2
Lung4.25
Lymphnode3.3
Lymphoma_burkitts(Daudi)4.95
Lymphoma_burkitts(Raji)5.5
MedullaOblongata3.55
OccipitalLobe3.5
OlfactoryBulb3.05
Ovary2.6
Pancreas3.15
PancreaticIslet4.15
ParietalLobe4.2
Pituitary4.55
Placenta4
Pons3.7
PrefrontalCortex4.8
Prostate4.5
Salivarygland3.1
SkeletalMuscle4.6
Skin3
SmoothMuscle4.4
Spinalcord4.15
SubthalamicNucleus3.55
SuperiorCervicalGanglion4.45
TemporalLobe3.55
Testis3.35
TestisGermCell3.25
TestisIntersitial3.25
TestisLeydigCell3.85
TestisSeminiferousTubule3.3
Thalamus3.95
Thymus3.05
Thyroid4.85
Tongue3.85
Tonsil3.8
Trachea3.25
TrigeminalGanglion4
Uterus3.2
UterusCorpus3.5
WholeBlood4.2
Wholebrain3.25
colon3.9
pineal_day4.84
pineal_night4.74
retina4.675
small_intestine3.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P58205
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.25 ± 1.03
Basal Forebrain2.89 ± 0.54
Basal Part of Pons2.32 ± 0.54
Cerebellar Cortex2.55 ± 0.92
Cerebellar Nuclei3.23 ± 1
Claustrum3.47 ± 0.93
Epithalamus2.34 ± 0.96
Frontal Lobe2.53 ± 0.77
Globus Pallidus3.56 ± 0.65
Hypothalamus3.03 ± 0.56
Insula2.59 ± 0.9
Limbic Lobe2.86 ± 0.92
Mesencephalon2.82 ± 0.91
Myelencephalon2.78 ± 0.82
Occipital Lobe2.88 ± 0.85
Parietal Lobe3.04 ± 0.99
Pontine Tegmentum3 ± 0.85
Striatum2.9 ± 0.85
Subthalamus2.65 ± 0.64
Temporal Lobe2.77 ± 0.99
Thalamus2.71 ± 0.82
White Matter2.67 ± 0.16
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
FETA_HUMAN_558 23 558 580 QKPQITEEQLEAVIADFSGLLEK PRIDE
PAp00000022 14 215 228 ESSLLNQHACAVMK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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