AutismKB 2.0

Annotation Detail for DLG2


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Basic Information Top
Gene Symbol:DLG2 ( DKFZp781D1854,DKFZp781E0954,FLJ37266,MGC131811,PSD-93,PSD93,chapsyn-110 )
Gene Full Name: discs, large homolog 2 (Drosophila)
Band: 11q14.1
Quick LinksEntrez ID:1740; OMIM: 603583; Uniprot ID:DLG2_HUMAN; ENSEMBL ID: ENSG00000150672; HGNC ID: 2901
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus40 / 56401270
neonate0 / 310970 
infant1 / 2362042
juvenile2 / 5555635
adult52 / 193912126
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor1 / 2638453
glioma1 / 1068839
head and neck tumor1 / 1363027
kidney tumor4 / 6895958
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia5 / 9725051
normal201 / 336030759
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS8 / 12568063
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone4 / 7165555
bone marrow1 / 4880120
brain132 / 1100989119
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus0 / 202090 
eye13 / 21105461
heart0 / 896260 
intestine1 / 2344724
kidney18 / 21177784
larynx1 / 2414541
liver3 / 20774314
lung5 / 33697414
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth0 / 670520 
muscle6 / 10771555
nerve0 / 157680 
ovary1 / 1020519
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta8 / 28082528
prostate2 / 18934510
salivary gland0 / 201550 
skin0 / 2105740 
spleen1 / 5395218
stomach3 / 9661931
testis8 / 33044224
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206253_at
Cell line Expression level Expression bar
721_B_lymphoblasts8
Adipocyte8.1
AdrenalCortex12.3
Adrenalgland7.6
Amygdala9
Appendix11.95
AtrioventricularNode11.55
BDCA4+_DentriticCells7.7
Bonemarrow8.65
BronchialEpithelialCells7.4
CD105+_Endothelial8.1
CD14+_Monocytes8.9
CD19+_BCells(neg._sel.)8.3
CD33+_Myeloid9.85
CD34+9.55
CD4+_Tcells7.7
CD56+_NKCells8.75
CD71+_EarlyErythroid7.85
CD8+_Tcells6.7
CardiacMyocytes11.75
Caudatenucleus7.45
Cerebellum6.8
CerebellumPeduncles10.45
CiliaryGanglion9.8
CingulateCortex10.6
Colorectaladenocarcinoma8.25
DorsalRootGanglion9.2
FetalThyroid8.7
Fetalbrain8.1
Fetalliver7.25
Fetallung5.75
GlobusPallidus7.2
Heart13.95
Hypothalamus9.15
Kidney7.9
Leukemia_chronicMyelogenousK-5627.05
Leukemia_promyelocytic-HL-607.15
Leukemialymphoblastic(MOLT-4)6.25
Liver14.3
Lung8.8
Lymphnode7.05
Lymphoma_burkitts(Daudi)10.65
Lymphoma_burkitts(Raji)12.55
MedullaOblongata9.7
OccipitalLobe8.4
OlfactoryBulb6.45
Ovary6.55
Pancreas6.8
PancreaticIslet9.1
ParietalLobe12.85
Pituitary9.65
Placenta7.5
Pons8.7
PrefrontalCortex15.8
Prostate9
Salivarygland7.2
SkeletalMuscle12.05
Skin11
SmoothMuscle9.2
Spinalcord8.55
SubthalamicNucleus8.6
SuperiorCervicalGanglion16.9
TemporalLobe8.65
Testis6.9
TestisGermCell6.75
TestisIntersitial7.4
TestisLeydigCell8.85
TestisSeminiferousTubule7.05
Thalamus8.55
Thymus6.25
Thyroid10.2
Tongue8.85
Tonsil8.25
Trachea6.9
TrigeminalGanglion9.2
Uterus6.4
UterusCorpus9.35
WholeBlood8.9
Wholebrain9.6
colon8
pineal_day10.76
pineal_night10.08
retina9.35
small_intestine7.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_234_PI416408490
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.91 ± 0.42
Basal Forebrain6.49 ± 0.35
Basal Part of Pons6.19 ± 0.44
Cerebellar Cortex6.19 ± 0.54
Cerebellar Nuclei6.35 ± 0.65
Claustrum7.39 ± 0.43
Epithalamus5.35 ± 0.76
Frontal Lobe6.62 ± 0.44
Globus Pallidus5.91 ± 0.67
Hypothalamus6.23 ± 0.53
Insula6.98 ± 0.55
Limbic Lobe7.1 ± 0.4
Mesencephalon6.51 ± 0.47
Myelencephalon6.54 ± 0.6
Occipital Lobe6.17 ± 0.7
Parietal Lobe6.71 ± 0.58
Pontine Tegmentum6.76 ± 0.52
Striatum6.65 ± 0.49
Subthalamus6.43 ± 0.09
Temporal Lobe6.84 ± 0.42
Thalamus6.19 ± 0.48
White Matter7.31 ± 0.78
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dlgh2CBCerebellum23.04
63.92
Dlgh2CTXCerebral cortex100
100
Dlgh2HIPHippocampal region90.85
100
Dlgh2HPFHippocampal formation97.46
100
Dlgh2HYHypothalamus22.23
15.95
Dlgh2LSXLateral septal complex100
100
Dlgh2MBMidbrain20.33
16.82
Dlgh2MYMedulla23.05
23.14
Dlgh2OLFOlfactory bulb100
100
Dlgh2PPons12.63
12.3
Dlgh2PALPallidum44.5
37.33
Dlgh2RHPRetrohippocampal region100
97.48
Dlgh2sAMYStriatum-like amygdalar nuclei86.84
62.06
Dlgh2STRStriatum100
86.04
Dlgh2STRdStriatum dorsal region100
84.16
Dlgh2STRvStriatum ventral region100
96.67
Dlgh2THThalamus8.84
9.12
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00002924 14 874 887 GKHCILDVSGNAIK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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