AutismKB 2.0

Annotation Detail for DLG4


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Basic Information Top
Gene Symbol:DLG4 ( FLJ97752,FLJ98574,PSD95,SAP-90,SAP90 )
Gene Full Name: discs, large homolog 4 (Drosophila)
Band: 17p13.1
Quick LinksEntrez ID:1742; OMIM: 602887; Uniprot ID:DLG4_HUMAN; ENSEMBL ID: ENSG00000132535; HGNC ID: 2903
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst2 / 6231932
fetus16 / 56401228
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult75 / 193912138
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor2 / 3436658
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor4 / 26384515
glioma3 / 10688328
head and neck tumor3 / 13630222
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor1 / 9635910
lung tumor1 / 1031279
lymphoma2 / 7175527
non-neoplasia3 / 9725030
normal112 / 336030733
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone0 / 716550 
bone marrow1 / 4880120
brain77 / 110098969
cervix2 / 4817141
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue7 / 21572232
esophagus0 / 202090 
eye9 / 21105442
heart0 / 896260 
intestine4 / 23447217
kidney2 / 2117779
larynx0 / 241450 
liver1 / 2077434
lung4 / 33697411
lymph2 / 4427045
lymph node0 / 916100 
mammary gland3 / 15327119
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary1 / 1020519
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta1 / 2808253
prostate9 / 18934547
salivary gland0 / 201550 
skin2 / 2105749
spleen0 / 539520 
stomach0 / 966190 
testis3 / 3304429
thymus1 / 8113112
thyroid2 / 4747342
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210684_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts15.15
Adipocyte13.4
AdrenalCortex20.55
Adrenalgland13.5
Amygdala12.75
Appendix13.8
AtrioventricularNode19.85
BDCA4+_DentriticCells13.35
Bonemarrow13.7
BronchialEpithelialCells11.55
CD105+_Endothelial13.3
CD14+_Monocytes14.85
CD19+_BCells(neg._sel.)14.1
CD33+_Myeloid18.35
CD34+17.1
CD4+_Tcells13.8
CD56+_NKCells16.3
CD71+_EarlyErythroid13.25
CD8+_Tcells11.15
CardiacMyocytes17.3
Caudatenucleus13
Cerebellum14
CerebellumPeduncles29.1
CiliaryGanglion38.6
CingulateCortex15.85
Colorectaladenocarcinoma12.4
DorsalRootGanglion14.05
FetalThyroid13.85
Fetalbrain13.05
Fetalliver11.8
Fetallung10.4
GlobusPallidus43.9
Heart17.75
Hypothalamus14.55
Kidney12.5
Leukemia_chronicMyelogenousK-56212.65
Leukemia_promyelocytic-HL-6012.5
Leukemialymphoblastic(MOLT-4)12.55
Liver17.75
Lung13.05
Lymphnode12.3
Lymphoma_burkitts(Daudi)17.25
Lymphoma_burkitts(Raji)18.9
MedullaOblongata12.8
OccipitalLobe16.4
OlfactoryBulb11.05
Ovary10.55
Pancreas13.8
PancreaticIslet17.05
ParietalLobe15.55
Pituitary16.05
Placenta12.55
Pons31.05
PrefrontalCortex16.65
Prostate14.45
Salivarygland11.5
SkeletalMuscle21.1
Skin18.75
SmoothMuscle13.7
Spinalcord22.6
SubthalamicNucleus51.15
SuperiorCervicalGanglion24.85
TemporalLobe22.8
Testis11
TestisGermCell10.6
TestisIntersitial12.35
TestisLeydigCell13.8
TestisSeminiferousTubule12
Thalamus36.8
Thymus8.1
Thyroid12.8
Tongue21.1
Tonsil14.05
Trachea13.2
TrigeminalGanglion14.05
Uterus9.2
UterusCorpus12.45
WholeBlood13
Wholebrain11.1
colon12.85
pineal_day18.48
pineal_night16.82
retina17
small_intestine12.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_235_PI416408490
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.7 ± 0.42
Basal Forebrain6.81 ± 0.24
Basal Part of Pons7.34 ± 0.3
Cerebellar Cortex7.05 ± 0.3
Cerebellar Nuclei6.24 ± 0.57
Claustrum7.23 ± 0.44
Epithalamus6.3 ± 0.46
Frontal Lobe7.02 ± 0.53
Globus Pallidus5.6 ± 0.46
Hypothalamus6.56 ± 0.53
Insula7.14 ± 0.39
Limbic Lobe7.59 ± 0.5
Mesencephalon6.82 ± 0.49
Myelencephalon7.05 ± 0.5
Occipital Lobe7.22 ± 0.51
Parietal Lobe7.11 ± 0.53
Pontine Tegmentum6.98 ± 0.65
Striatum7.73 ± 0.43
Subthalamus6.46 ± 0.28
Temporal Lobe7.24 ± 0.43
Thalamus6.94 ± 0.45
White Matter4.9 ± 0.47
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dlgh4CBCerebellum100
100
Dlgh4CTXCerebral cortex100
100
Dlgh4HIPHippocampal region100
100
Dlgh4HPFHippocampal formation100
100
Dlgh4HYHypothalamus100
100
Dlgh4LSXLateral septal complex100
100
Dlgh4MBMidbrain100
100
Dlgh4MYMedulla66.1
100
Dlgh4OLFOlfactory bulb100
100
Dlgh4PPons71.24
100
Dlgh4PALPallidum100
100
Dlgh4RHPRetrohippocampal region100
100
Dlgh4sAMYStriatum-like amygdalar nuclei100
100
Dlgh4STRStriatum100
100
Dlgh4STRdStriatum dorsal region100
100
Dlgh4STRvStriatum ventral region100
100
Dlgh4THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00067309 12 602 613 FGSCVPHTTRPK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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