AutismKB 2.0

Annotation Detail for DLX4


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Basic Information Top
Gene Symbol:DLX4 ( BP1,DLX7,DLX8,DLX9 )
Gene Full Name: distal-less homeobox 4
Band: 17q21.33
Quick LinksEntrez ID:1748; OMIM: 601911; Uniprot ID:DLX4_HUMAN; ENSEMBL ID: ENSG00000108813; HGNC ID: 2917
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus4 / 5640127
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult27 / 193912113
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor2 / 2638457
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor1 / 9635910
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal29 / 33603078
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma2 / 4635643
skin tumor2 / 12494916
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain0 / 11009890 
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye2 / 2110549
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver1 / 2077434
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta27 / 28082596
prostate0 / 1893450 
salivary gland0 / 201550 
skin2 / 2105749
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208216_at
Cell line Expression level Expression bar
721_B_lymphoblasts11.9
Adipocyte11.25
AdrenalCortex17.3
Adrenalgland11.35
Amygdala11.7
Appendix16.65
AtrioventricularNode16.45
BDCA4+_DentriticCells11.8
Bonemarrow12.2
BronchialEpithelialCells11.2
CD105+_Endothelial11.75
CD14+_Monocytes13
CD19+_BCells(neg._sel.)12.15
CD33+_Myeloid13.7
CD34+12.6
CD4+_Tcells12.65
CD56+_NKCells11.55
CD71+_EarlyErythroid11.2
CD8+_Tcells10.15
CardiacMyocytes15.7
Caudatenucleus10.7
Cerebellum11
CerebellumPeduncles14.85
CiliaryGanglion12.65
CingulateCortex12.95
Colorectaladenocarcinoma12.05
DorsalRootGanglion10.05
FetalThyroid16.75
Fetalbrain11.2
Fetalliver11
Fetallung9.05
GlobusPallidus8.9
Heart19.3
Hypothalamus12
Kidney12.2
Leukemia_chronicMyelogenousK-56224.2
Leukemia_promyelocytic-HL-6010.6
Leukemialymphoblastic(MOLT-4)9.2
Liver18.8
Lung12.7
Lymphnode10.25
Lymphoma_burkitts(Daudi)15.25
Lymphoma_burkitts(Raji)18
MedullaOblongata10.55
OccipitalLobe10.65
OlfactoryBulb9.3
Ovary7.95
Pancreas9.65
PancreaticIslet12.6
ParietalLobe13.2
Pituitary13.7
Placenta47.65
Pons11.9
PrefrontalCortex13.7
Prostate13.65
Salivarygland9.7
SkeletalMuscle25.15
Skin9.95
SmoothMuscle12.65
Spinalcord14.6
SubthalamicNucleus10.9
SuperiorCervicalGanglion20
TemporalLobe10.95
Testis10.1
TestisGermCell9.65
TestisIntersitial10
TestisLeydigCell11.85
TestisSeminiferousTubule10.2
Thalamus12.15
Thymus9.2
Thyroid14
Tongue16.5
Tonsil11.45
Trachea10
TrigeminalGanglion21.2
Uterus11
UterusCorpus13.4
WholeBlood12.75
Wholebrain9.2
colon12
pineal_day14.16
pineal_night13.26
retina14
small_intestine11.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16853_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.84 ± 0.8
Basal Forebrain8.79 ± 0.47
Basal Part of Pons8.53 ± 0.64
Cerebellar Cortex8.05 ± 0.39
Cerebellar Nuclei9.26 ± 0.38
Claustrum9.16 ± 0.82
Epithalamus7.79 ± 0.71
Frontal Lobe8.68 ± 0.7
Globus Pallidus9.33 ± 0.47
Hypothalamus8.66 ± 0.48
Insula8.38 ± 0.59
Limbic Lobe8.7 ± 0.73
Mesencephalon8.89 ± 0.58
Myelencephalon8.74 ± 0.71
Occipital Lobe8.61 ± 0.77
Parietal Lobe8.64 ± 0.61
Pontine Tegmentum8.67 ± 0.56
Striatum9.2 ± 0.75
Subthalamus8.87 ± 0.21
Temporal Lobe8.51 ± 0.74
Thalamus8.98 ± 0.49
White Matter8.55 ± 0.38
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dlx4CBCerebellum4.51
5.64
Dlx4CTXCerebral cortex2.15
2.37
Dlx4HIPHippocampal region1.58
1.94
Dlx4HPFHippocampal formation1.42
1.63
Dlx4HYHypothalamus0.31
0.29
Dlx4LSXLateral septal complex0.19
0.37
Dlx4MBMidbrain1.69
2.35
Dlx4MYMedulla1.45
1.8
Dlx4OLFOlfactory bulb2.41
2.98
Dlx4PPons0.63
0.8
Dlx4PALPallidum0.45
0.46
Dlx4RHPRetrohippocampal region1.12
1.15
Dlx4sAMYStriatum-like amygdalar nuclei1.69
2.17
Dlx4STRStriatum1.11
1.17
Dlx4STRdStriatum dorsal region0.95
0.97
Dlx4STRvStriatum ventral region1.44
1.41
Dlx4THThalamus1.25
2.42
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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