AutismKB 2.0

Annotation Detail for DLX5


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Basic Information Top
Gene Symbol:DLX5 ( - )
Gene Full Name: distal-less homeobox 5
Band: 7q21.3
Quick LinksEntrez ID:1749; OMIM: 600028; Uniprot ID:DLX5_HUMAN; ENSEMBL ID: ENSG00000105880; HGNC ID: 2918
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus12 / 56401221
neonate0 / 310970 
infant1 / 2362042
juvenile0 / 555560 
adult24 / 193912112
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor0 / 2638450 
glioma1 / 1068839
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor5 / 10312748
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal28 / 33603078
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone4 / 7165555
bone marrow0 / 488010 
brain10 / 11009899
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney1 / 2117774
larynx0 / 241450 
liver0 / 2077430 
lung6 / 33697417
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth2 / 6705229
muscle0 / 1077150 
nerve1 / 1576863
ovary1 / 1020519
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta12 / 28082542
prostate2 / 18934510
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach1 / 9661910
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus7 / 23287830
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 213707_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.4
Adipocyte3.5
AdrenalCortex3.7
Adrenalgland2.95
Amygdala3.7
Appendix3.55
AtrioventricularNode2.7
BDCA4+_DentriticCells3.9
Bonemarrow3.5
BronchialEpithelialCells3.45
CD105+_Endothelial3.6
CD14+_Monocytes3.8
CD19+_BCells(neg._sel.)3.75
CD33+_Myeloid4.55
CD34+4.5
CD4+_Tcells3.9
CD56+_NKCells4.25
CD71+_EarlyErythroid3.35
CD8+_Tcells3.4
CardiacMyocytes4.45
Caudatenucleus3.15
Cerebellum2.9
CerebellumPeduncles4
CiliaryGanglion2.5
CingulateCortex3.6
Colorectaladenocarcinoma3.55
DorsalRootGanglion2.7
FetalThyroid3.45
Fetalbrain3.6
Fetalliver3.05
Fetallung3
GlobusPallidus2.6
Heart4.45
Hypothalamus3.85
Kidney2.85
Leukemia_chronicMyelogenousK-5623.2
Leukemia_promyelocytic-HL-603.1
Leukemialymphoblastic(MOLT-4)2.85
Liver4.7
Lung3.9
Lymphnode3.05
Lymphoma_burkitts(Daudi)4.5
Lymphoma_burkitts(Raji)4.9
MedullaOblongata3.25
OccipitalLobe3.2
OlfactoryBulb2.8
Ovary2.35
Pancreas2.85
PancreaticIslet3.8
ParietalLobe3.75
Pituitary4.1
Placenta16.15
Pons3.35
PrefrontalCortex4.4
Prostate4.15
Salivarygland2.85
SkeletalMuscle4.1
Skin2.75
SmoothMuscle4
Spinalcord3.8
SubthalamicNucleus3.2
SuperiorCervicalGanglion4.3
TemporalLobe3.25
Testis3.05
TestisGermCell3
TestisIntersitial2.95
TestisLeydigCell3.55
TestisSeminiferousTubule3.05
Thalamus3.6
Thymus2.8
Thyroid4.4
Tongue3.45
Tonsil3.45
Trachea3
TrigeminalGanglion3.65
Uterus2.9
UterusCorpus3.15
WholeBlood3.9
Wholebrain2.95
colon3.55
pineal_day4.42
pineal_night4.32
retina4.275
small_intestine3.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_10476_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.33 ± 0.58
Basal Forebrain5.58 ± 0.34
Basal Part of Pons3.17 ± 0.54
Cerebellar Cortex2.85 ± 0.45
Cerebellar Nuclei3.28 ± 0.44
Claustrum3.82 ± 0.54
Epithalamus3.02 ± 0.87
Frontal Lobe3.53 ± 0.74
Globus Pallidus3.76 ± 1.06
Hypothalamus4.57 ± 0.7
Insula3.43 ± 0.57
Limbic Lobe3.72 ± 0.73
Mesencephalon3.58 ± 0.87
Myelencephalon3.7 ± 0.91
Occipital Lobe3.75 ± 1
Parietal Lobe3.87 ± 0.88
Pontine Tegmentum3.71 ± 0.82
Striatum5.59 ± 0.61
Subthalamus3.65 ± 0.71
Temporal Lobe3.52 ± 0.64
Thalamus3.23 ± 0.86
White Matter1.95 ± 0.94
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dlx5CBCerebellum32.19
35.63
Dlx5CTXCerebral cortex24.06
14.46
Dlx5HIPHippocampal region23.83
13.32
Dlx5HPFHippocampal formation25.05
16.08
Dlx5HYHypothalamus15.9
10.82
Dlx5LSXLateral septal complex8.03
4.35
Dlx5MBMidbrain17.79
14.16
Dlx5MYMedulla29.89
30.66
Dlx5OLFOlfactory bulb45.41
23.5
Dlx5PPons26.92
25.13
Dlx5PALPallidum17.51
13.91
Dlx5RHPRetrohippocampal region26.83
19.21
Dlx5sAMYStriatum-like amygdalar nuclei21.62
11.47
Dlx5STRStriatum12.43
6.99
Dlx5STRdStriatum dorsal region7.72
4.36
Dlx5STRvStriatum ventral region25.54
13.78
Dlx5THThalamus16.6
10.69
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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