AutismKB 2.0

Annotation Detail for DLX6


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Basic Information Top
Gene Symbol:DLX6 ( MGC125282,MGC125283,MGC125284,MGC125285 )
Gene Full Name: distal-less homeobox 6
Band: 7q21.3
Quick LinksEntrez ID:1750; OMIM: 600030; Uniprot ID:B3KSQ0_HUMAN; ENSEMBL ID: ENSG00000006377; HGNC ID: 2919
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus7 / 56401212
neonate0 / 310970 
infant1 / 2362042
juvenile1 / 5555617
adult10 / 19391215
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor1 / 2638453
glioma0 / 1068830 
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal17 / 33603075
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain6 / 11009895
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart3 / 8962633
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth2 / 6705229
muscle0 / 1077150 
nerve1 / 1576863
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta3 / 28082510
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis1 / 3304423
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus5 / 23287821
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221289_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.5
Adipocyte3.8
AdrenalCortex5.3
Adrenalgland3.3
Amygdala4.05
Appendix5.35
AtrioventricularNode4.6
BDCA4+_DentriticCells4.05
Bonemarrow3.8
BronchialEpithelialCells3.85
CD105+_Endothelial3.9
CD14+_Monocytes4.1
CD19+_BCells(neg._sel.)4.15
CD33+_Myeloid4.95
CD34+4.9
CD4+_Tcells3.9
CD56+_NKCells3.95
CD71+_EarlyErythroid3.6
CD8+_Tcells3.45
CardiacMyocytes4.95
Caudatenucleus3.45
Cerebellum3.15
CerebellumPeduncles4.4
CiliaryGanglion4.25
CingulateCortex4.3
Colorectaladenocarcinoma3.9
DorsalRootGanglion3.5
FetalThyroid3.75
Fetalbrain3.85
Fetalliver3.3
Fetallung3.25
GlobusPallidus2.95
Heart5.2
Hypothalamus4.2
Kidney3.15
Leukemia_chronicMyelogenousK-5623.5
Leukemia_promyelocytic-HL-603.4
Leukemialymphoblastic(MOLT-4)3.15
Liver5.05
Lung4.25
Lymphnode3.3
Lymphoma_burkitts(Daudi)4.9
Lymphoma_burkitts(Raji)5.5
MedullaOblongata3.55
OccipitalLobe3.45
OlfactoryBulb3.05
Ovary2.75
Pancreas3.15
PancreaticIslet4.15
ParietalLobe4.45
Pituitary4.55
Placenta4
Pons3.65
PrefrontalCortex4.75
Prostate4.5
Salivarygland3.35
SkeletalMuscle5.85
Skin2.95
SmoothMuscle4.35
Spinalcord4.15
SubthalamicNucleus3.65
SuperiorCervicalGanglion4.35
TemporalLobe4.9
Testis3.35
TestisGermCell3.25
TestisIntersitial3.45
TestisLeydigCell3.85
TestisSeminiferousTubule3.3
Thalamus3.9
Thymus3.05
Thyroid4.85
Tongue3.85
Tonsil3.8
Trachea3.2
TrigeminalGanglion5.5
Uterus3.15
UterusCorpus3.55
WholeBlood4.3
Wholebrain3.25
colon3.85
pineal_day4.68
pineal_night4.44
retina4.475
small_intestine3.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_5737_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.19 ± 1.09
Basal Forebrain4.55 ± 0.54
Basal Part of Pons2.36 ± 0.46
Cerebellar Cortex2.1 ± 0.3
Cerebellar Nuclei2.88 ± 0.67
Claustrum3.2 ± 0.65
Epithalamus2.38 ± 1.12
Frontal Lobe2.66 ± 0.88
Globus Pallidus2.89 ± 0.59
Hypothalamus3.12 ± 1
Insula2.42 ± 0.9
Limbic Lobe2.69 ± 0.77
Mesencephalon2.97 ± 0.95
Myelencephalon2.86 ± 0.89
Occipital Lobe2.63 ± 0.8
Parietal Lobe2.87 ± 0.98
Pontine Tegmentum2.9 ± 0.93
Striatum5.13 ± 0.52
Subthalamus2.87 ± 0.96
Temporal Lobe2.56 ± 0.8
Thalamus2.58 ± 0.77
White Matter2.38 ± 0.14
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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