AutismKB 2.0

Annotation Detail for DNM1


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Basic Information Top
Gene Symbol:DNM1 ( DNM )
Gene Full Name: dynamin 1
Band: 9q34.11
Quick LinksEntrez ID:1759; OMIM: 602377; Uniprot ID:DYN1_HUMAN; ENSEMBL ID: ENSG00000106976; HGNC ID: 2972
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst2 / 6231932
fetus24 / 56401242
neonate0 / 310970 
infant0 / 236200 
juvenile5 / 5555689
adult92 / 193912147
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor5 / 26384518
glioma10 / 10688393
head and neck tumor2 / 13630214
kidney tumor2 / 6895929
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia7 / 9725071
normal286 / 336030785
ovarian tumor3 / 7668239
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer1 / 1026809
retinoblastoma2 / 4635643
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow2 / 4880140
brain265 / 1100989240
cervix0 / 481710 
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue7 / 21572232
esophagus0 / 202090 
eye12 / 21105456
heart1 / 8962611
intestine5 / 23447221
kidney3 / 21177714
larynx1 / 2414541
liver0 / 2077430 
lung6 / 33697417
lymph0 / 442700 
lymph node1 / 9161010
mammary gland2 / 15327113
mouth0 / 670520 
muscle1 / 1077159
nerve5 / 15768317
ovary3 / 10205129
pancreas11 / 21481251
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta4 / 28082514
prostate3 / 18934515
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach0 / 966190 
testis4 / 33044212
thymus1 / 8113112
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 215116_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts12.95
Adipocyte24.95
AdrenalCortex14.15
Adrenalgland15.25
Amygdala5932.45
Appendix16.05
AtrioventricularNode12.8
BDCA4+_DentriticCells12.95
Bonemarrow12.2
BronchialEpithelialCells12.35
CD105+_Endothelial12
CD14+_Monocytes13.65
CD19+_BCells(neg._sel.)14.1
CD33+_Myeloid14.2
CD34+21.55
CD4+_Tcells12.95
CD56+_NKCells13.85
CD71+_EarlyErythroid12.9
CD8+_Tcells11.25
CardiacMyocytes17.3
Caudatenucleus701.1
Cerebellum2200.6
CerebellumPeduncles2850.9
CiliaryGanglion39.55
CingulateCortex3332.9
Colorectaladenocarcinoma228.6
DorsalRootGanglion56.8
FetalThyroid19.65
Fetalbrain593
Fetalliver13.2
Fetallung14.55
GlobusPallidus1537.75
Heart23.4
Hypothalamus1506.5
Kidney23.75
Leukemia_chronicMyelogenousK-562132.3
Leukemia_promyelocytic-HL-6012.15
Leukemialymphoblastic(MOLT-4)13.5
Liver27
Lung17.75
Lymphnode22.55
Lymphoma_burkitts(Daudi)15.75
Lymphoma_burkitts(Raji)18.8
MedullaOblongata2069.15
OccipitalLobe2497.7
OlfactoryBulb20.95
Ovary8.35
Pancreas17.4
PancreaticIslet29.55
ParietalLobe2659.35
Pituitary133.1
Placenta12.85
Pons1333.9
PrefrontalCortex7384.2
Prostate17.5
Salivarygland11.6
SkeletalMuscle21.7
Skin16.8
SmoothMuscle17.25
Spinalcord307.65
SubthalamicNucleus2776.45
SuperiorCervicalGanglion29.7
TemporalLobe2214.05
Testis11.85
TestisGermCell12.2
TestisIntersitial12.15
TestisLeydigCell17.35
TestisSeminiferousTubule14.3
Thalamus1662.85
Thymus11.1
Thyroid17.35
Tongue13.35
Tonsil14.9
Trachea17.9
TrigeminalGanglion16.95
Uterus21.3
UterusCorpus12.2
WholeBlood12.75
Wholebrain5007.8
colon12.7
pineal_day2739.54
pineal_night2496.48
retina421.7
small_intestine12.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16396_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.78 ± 0.47
Basal Forebrain5.79 ± 0.34
Basal Part of Pons7.23 ± 0.26
Cerebellar Cortex6.88 ± 0.23
Cerebellar Nuclei6.12 ± 0.86
Claustrum7.03 ± 0.33
Epithalamus5.11 ± 0.78
Frontal Lobe6.57 ± 0.49
Globus Pallidus5.05 ± 0.6
Hypothalamus5.9 ± 0.69
Insula6.6 ± 0.27
Limbic Lobe6.88 ± 0.44
Mesencephalon6.2 ± 0.78
Myelencephalon6.4 ± 0.71
Occipital Lobe6.74 ± 0.51
Parietal Lobe6.54 ± 0.45
Pontine Tegmentum6.28 ± 0.51
Striatum5.13 ± 0.71
Subthalamus6.47 ± 0.37
Temporal Lobe6.81 ± 0.3
Thalamus6.32 ± 0.44
White Matter3.62 ± 0.75
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dnm1CBCerebellum0
0
Dnm1CTXCerebral cortex0
0
Dnm1HIPHippocampal region0
0
Dnm1HPFHippocampal formation0
0
Dnm1HYHypothalamus0
0
Dnm1LSXLateral septal complex0
0
Dnm1MBMidbrain0
0
Dnm1MYMedulla0
0
Dnm1OLFOlfactory bulb0
0
Dnm1PPons0
0
Dnm1PALPallidum0
0
Dnm1RHPRetrohippocampal region0
0
Dnm1sAMYStriatum-like amygdalar nuclei0
0
Dnm1STRStriatum0
0
Dnm1STRdStriatum dorsal region0
0
Dnm1STRvStriatum ventral region0
0
Dnm1THThalamus0
0
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
DYN1_HUMAN_114 10 114 123 GISPVPINLR PRIDE
DYN1_HUMAN_267 5 267 271 HLADR PRIDE
DYN1_HUMAN_291 7 291 297 DTLPGLR PRIDE
DYN1_HUMAN_297 12 297 308 NKLQSQLLSIEK PRIDE
DYN1_HUMAN_400 15 400 414 TGLFTPDMAFETIVK PRIDE
DYN1_HUMAN_445 7 445 451 KLQQYPR PRIDE
DYN1_HUMAN_446 6 446 451 LQQYPR PRIDE
DYN1_HUMAN_5 11 5 15 GMEDLIPLVNR PRIDE
DYN1_HUMAN_511 12 511 522 TSGNQDEILVIR PRIDE
DYN1_HUMAN_60 7 60 66 GSGIVTR PRIDE
DYN1_HUMAN_676 8 676 683 TVRDLMPK PRIDE
DYN1_HUMAN_684 11 684 694 TIMHLMINNTK PRIDE
DYN1_HUMAN_773 11 773 783 RSPTSSPTPQR PRIDE
DYN1_HUMAN_774 10 774 783 SPTSSPTPQR PRIDE
PAp00066009 30 695 724 EFIFSELLANLYSCGDQNTLMEESAEQAQR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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