AutismKB 2.0

Annotation Detail for DNA2


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Basic Information Top
Gene Symbol:DNA2 ( DNA2L,FLJ10063,KIAA0083,MGC133297 )
Gene Full Name: DNA replication helicase 2 homolog (yeast)
Band: 10q21.3
Quick LinksEntrez ID:1763; OMIM: 601810; Uniprot ID:DNA2L_HUMAN; ENSEMBL ID: ENSG00000138346; HGNC ID: 2939
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst5 / 6231980
fetus5 / 5640128
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult16 / 19391218
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor2 / 2638457
glioma0 / 1068830 
head and neck tumor7 / 13630251
kidney tumor0 / 689590 
leukemia4 / 9584241
liver tumor1 / 9635910
lung tumor0 / 1031270 
lymphoma6 / 7175583
non-neoplasia0 / 972500 
normal36 / 336030710
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder1 / 2975733
blood2 / 12347816
bone0 / 716550 
bone marrow4 / 4880181
brain3 / 11009892
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue7 / 21572232
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine3 / 23447212
kidney2 / 2117779
larynx2 / 2414582
liver1 / 2077434
lung0 / 3369740 
lymph2 / 4427045
lymph node12 / 91610130
mammary gland2 / 15327113
mouth5 / 6705274
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate2 / 18934510
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach2 / 9661920
testis2 / 3304426
thymus5 / 8113161
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 213647_at
Cell line Expression level Expression bar
721_B_lymphoblasts44.55
Adipocyte6.2
AdrenalCortex7.1
Adrenalgland5.5
Amygdala6.15
Appendix9.25
AtrioventricularNode5.75
BDCA4+_DentriticCells6.9
Bonemarrow6.7
BronchialEpithelialCells5.95
CD105+_Endothelial9.05
CD14+_Monocytes6.55
CD19+_BCells(neg._sel.)6.55
CD33+_Myeloid7.9
CD34+17.75
CD4+_Tcells6.45
CD56+_NKCells7.25
CD71+_EarlyErythroid6.5
CD8+_Tcells5.7
CardiacMyocytes8.6
Caudatenucleus5.7
Cerebellum5.15
CerebellumPeduncles7.65
CiliaryGanglion9.05
CingulateCortex6.7
Colorectaladenocarcinoma6.15
DorsalRootGanglion6.6
FetalThyroid6.15
Fetalbrain6.15
Fetalliver5.55
Fetallung4.65
GlobusPallidus5.05
Heart8.5
Hypothalamus6.75
Kidney5.45
Leukemia_chronicMyelogenousK-5627.5
Leukemia_promyelocytic-HL-608.7
Leukemialymphoblastic(MOLT-4)9.85
Liver8.45
Lung6.75
Lymphnode5.15
Lymphoma_burkitts(Daudi)10.35
Lymphoma_burkitts(Raji)9.1
MedullaOblongata5.75
OccipitalLobe5.65
OlfactoryBulb4.95
Ovary4.35
Pancreas5.25
PancreaticIslet6.7
ParietalLobe7.05
Pituitary7.4
Placenta6.2
Pons6.4
PrefrontalCortex7.3
Prostate7
Salivarygland5.4
SkeletalMuscle8.75
Skin5.25
SmoothMuscle7.05
Spinalcord6.7
SubthalamicNucleus5.95
SuperiorCervicalGanglion8.4
TemporalLobe5.9
Testis5.4
TestisGermCell5
TestisIntersitial5.25
TestisLeydigCell6.5
TestisSeminiferousTubule5.4
Thalamus6.55
Thymus4.7
Thyroid7.3
Tongue6.95
Tonsil6.2
Trachea5.25
TrigeminalGanglion7.5
Uterus4.9
UterusCorpus5.8
WholeBlood6.7
Wholebrain4.9
colon6.35
pineal_day7.82
pineal_night7.46
retina7.475
small_intestine6.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P366107
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.7 ± 0.5
Basal Forebrain4.6 ± 0.39
Basal Part of Pons5.06 ± 0.43
Cerebellar Cortex5.14 ± 0.34
Cerebellar Nuclei5.12 ± 0.45
Claustrum4.97 ± 0.67
Epithalamus4.7 ± 0.52
Frontal Lobe4.63 ± 0.44
Globus Pallidus4.74 ± 0.34
Hypothalamus4.51 ± 0.53
Insula4.65 ± 0.48
Limbic Lobe4.84 ± 0.53
Mesencephalon4.72 ± 0.56
Myelencephalon4.81 ± 0.49
Occipital Lobe5.4 ± 0.53
Parietal Lobe4.87 ± 0.41
Pontine Tegmentum4.89 ± 0.45
Striatum4.9 ± 0.45
Subthalamus5.25 ± 0.39
Temporal Lobe4.73 ± 0.43
Thalamus5.09 ± 0.35
White Matter6.29 ± 0.45
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dna2lCBCerebellum2.5
3.38
Dna2lCTXCerebral cortex1.22
1.53
Dna2lHIPHippocampal region0.57
0.52
Dna2lHPFHippocampal formation0.61
0.65
Dna2lHYHypothalamus0.15
0.29
Dna2lLSXLateral septal complex0
0
Dna2lMBMidbrain0.89
1.13
Dna2lMYMedulla2.46
3.28
Dna2lOLFOlfactory bulb2.37
3.3
Dna2lPPons1.57
2.19
Dna2lPALPallidum0.17
0.15
Dna2lRHPRetrohippocampal region0.62
0.78
Dna2lsAMYStriatum-like amygdalar nuclei0.1
0.14
Dna2lSTRStriatum0.25
0.33
Dna2lSTRdStriatum dorsal region0.27
0.35
Dna2lSTRvStriatum ventral region0.36
0.44
Dna2lTHThalamus0.29
0.29
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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