AutismKB 2.0

Annotation Detail for DNASE1


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Basic Information Top
Gene Symbol:DNASE1 ( DKFZp686H0155,DNL1,DRNI,FLJ38093,FLJ44902 )
Gene Full Name: deoxyribonuclease I
Band: 16p13.3
Quick LinksEntrez ID:1773; OMIM: 125505; Uniprot ID:DNAS1_HUMAN; ENSEMBL ID: ENSG00000213918; HGNC ID: 2956
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst0 / 623190 
fetus14 / 56401224
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult54 / 193912127
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor1 / 3436629
chondrosarcoma3 / 8282336
colorectal tumor3 / 11424626
esophageal tumor1 / 1729057
gastrointestinal tumor4 / 11936933
germ cell tumor15 / 26384556
glioma2 / 10688318
head and neck tumor6 / 13630244
kidney tumor0 / 689590 
leukemia2 / 9584220
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma3 / 7175541
non-neoplasia0 / 972500 
normal78 / 336030723
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer4 / 10268038
retinoblastoma1 / 4635621
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites3 / 4001574
bladder0 / 297570 
blood3 / 12347824
bone2 / 7165527
bone marrow0 / 488010 
brain15 / 110098913
cervix1 / 4817120
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus1 / 2020949
eye5 / 21105423
heart3 / 8962633
intestine11 / 23447246
kidney4 / 21177718
larynx0 / 241450 
liver1 / 2077434
lung7 / 33697420
lymph2 / 4427045
lymph node14 / 91610152
mammary gland3 / 15327119
mouth5 / 6705274
muscle5 / 10771546
nerve1 / 1576863
ovary2 / 10205119
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta4 / 28082514
prostate12 / 18934563
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach1 / 9661910
testis7 / 33044221
thymus5 / 8113161
thyroid0 / 474730 
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord0 / 136800 
uterus5 / 23287821
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210165_at
Cell line Expression level Expression bar
721_B_lymphoblasts3.95
Adipocyte3.05
AdrenalCortex3.15
Adrenalgland2.6
Amygdala3.3
Appendix3.1
AtrioventricularNode2.3
BDCA4+_DentriticCells3.5
Bonemarrow3
BronchialEpithelialCells3.05
CD105+_Endothelial3.15
CD14+_Monocytes3.3
CD19+_BCells(neg._sel.)3.35
CD33+_Myeloid4
CD34+3.95
CD4+_Tcells3.45
CD56+_NKCells3.8
CD71+_EarlyErythroid2.9
CD8+_Tcells3.05
CardiacMyocytes3.9
Caudatenucleus2.75
Cerebellum2.5
CerebellumPeduncles3.5
CiliaryGanglion2.15
CingulateCortex3.15
Colorectaladenocarcinoma3.1
DorsalRootGanglion2.35
FetalThyroid3
Fetalbrain3.15
Fetalliver2.7
Fetallung2.65
GlobusPallidus2.25
Heart3.9
Hypothalamus3.4
Kidney2.65
Leukemia_chronicMyelogenousK-5622.85
Leukemia_promyelocytic-HL-602.7
Leukemialymphoblastic(MOLT-4)2.5
Liver4.05
Lung3.45
Lymphnode2.7
Lymphoma_burkitts(Daudi)3.95
Lymphoma_burkitts(Raji)4.3
MedullaOblongata2.8
OccipitalLobe2.75
OlfactoryBulb2.45
Ovary2.05
Pancreas5.55
PancreaticIslet3.3
ParietalLobe3.25
Pituitary3.6
Placenta3.25
Pons2.95
PrefrontalCortex3.9
Prostate3.65
Salivarygland2.45
SkeletalMuscle3.5
Skin2.35
SmoothMuscle3.5
Spinalcord3.3
SubthalamicNucleus2.8
SuperiorCervicalGanglion3.45
TemporalLobe2.8
Testis2.65
TestisGermCell2.6
TestisIntersitial2.6
TestisLeydigCell3.05
TestisSeminiferousTubule2.65
Thalamus3.1
Thymus2.45
Thyroid3.9
Tongue3.05
Tonsil3.05
Trachea2.6
TrigeminalGanglion3.1
Uterus2.55
UterusCorpus2.75
WholeBlood3.4
Wholebrain2.65
colon3.15
pineal_day3.86
pineal_night3.8
retina3.775
small_intestine9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16749_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.05 ± 0.96
Basal Forebrain1.41 ± 0.22
Basal Part of Pons1.17 ± 0.38
Cerebellar Cortex1.88 ± 0.66
Cerebellar Nuclei1.81 ± 0.68
Claustrum2.26 ± 0.75
Epithalamus1.22 ± 0.77
Frontal Lobe1.47 ± 0.71
Globus Pallidus1.69 ± 0.39
Hypothalamus1.56 ± 0.68
Insula1.78 ± 0.6
Limbic Lobe1.54 ± 0.62
Mesencephalon1.73 ± 0.73
Myelencephalon1.6 ± 0.66
Occipital Lobe1.61 ± 0.7
Parietal Lobe1.57 ± 0.72
Pontine Tegmentum1.65 ± 0.64
Striatum1.47 ± 0.57
Subthalamus1.73 ± 0.68
Temporal Lobe1.49 ± 0.76
Thalamus1.47 ± 0.64
White Matter1.75 ± 0.14
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dnase1CBCerebellum0.59
1.86
Dnase1CTXCerebral cortex0.92
1.39
Dnase1HIPHippocampal region0.2
0.5
Dnase1HPFHippocampal formation0.22
0.47
Dnase1HYHypothalamus0.21
0.3
Dnase1LSXLateral septal complex0
0
Dnase1MBMidbrain0.21
0.34
Dnase1MYMedulla0.85
1.71
Dnase1OLFOlfactory bulb0.29
0.82
Dnase1PPons0.4
0.64
Dnase1PALPallidum0.11
0.09
Dnase1RHPRetrohippocampal region0.23
0.39
Dnase1sAMYStriatum-like amygdalar nuclei0.08
0.09
Dnase1STRStriatum0.14
0.22
Dnase1STRdStriatum dorsal region0.16
0.26
Dnase1STRvStriatum ventral region0.16
0.19
Dnase1THThalamus0.18
0.26
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00796018 13 25 37 IAAFNIQTFGETK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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