AutismKB 2.0

Annotation Detail for DYNC1I2


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Basic Information Top
Gene Symbol:DYNC1I2 ( DNCI2,FLJ21089,FLJ90842,IC2,MGC104199,MGC111094,MGC9324 )
Gene Full Name: dynein, cytoplasmic 1, intermediate chain 2
Band: 2q31.1
Quick LinksEntrez ID:1781; OMIM: 603331; Uniprot ID:DC1I2_HUMAN; ENSEMBL ID: ENSG00000077380; HGNC ID: 2964
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body13 / 70761183
blastocyst10 / 62319160
fetus221 / 564012391
neonate11 / 31097353
infant6 / 23620254
juvenile25 / 55556449
adult224 / 1939121115
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor15 / 94178159
cervical tumor3 / 3436687
chondrosarcoma1 / 8282312
colorectal tumor8 / 11424670
esophageal tumor8 / 17290462
gastrointestinal tumor16 / 119369134
germ cell tumor87 / 263845329
glioma13 / 106883121
head and neck tumor18 / 136302132
kidney tumor16 / 68959232
leukemia14 / 95842146
liver tumor20 / 96359207
lung tumor2 / 10312719
lymphoma3 / 7175541
non-neoplasia18 / 97250185
normal815 / 3360307242
ovarian tumor8 / 76682104
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS22 / 125680175
prostate cancer3 / 10268029
retinoblastoma6 / 46356129
skin tumor11 / 12494988
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor15 / 90257166
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland5 / 33197150
ascites5 / 40015124
bladder8 / 29757268
blood14 / 123478113
bone4 / 7165555
bone marrow12 / 48801245
brain503 / 1100989456
cervix6 / 48171124
connective tissue15 / 149255100
ear2 / 16212123
embryonic tissue33 / 215722152
esophagus9 / 20209445
eye25 / 211054118
heart11 / 89626122
intestine37 / 234472157
kidney49 / 211777231
larynx0 / 241450 
liver41 / 207743197
lung32 / 33697494
lymph1 / 4427022
lymph node8 / 9161087
mammary gland21 / 153271137
mouth14 / 67052208
muscle8 / 10771574
nerve2 / 15768126
ovary9 / 10205188
pancreas9 / 21481241
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland3 / 16585180
placenta30 / 280825106
prostate11 / 18934558
salivary gland1 / 2015549
skin34 / 210574161
spleen14 / 53952259
stomach10 / 96619103
testis77 / 330442233
thymus17 / 81131209
thyroid4 / 4747384
tonsil0 / 169990 
trachea17 / 52413324
umbilical cord1 / 1368073
uterus42 / 232878180
vascular39 / 51780753
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211684_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts196.85
Adipocyte156.15
AdrenalCortex70.2
Adrenalgland78.1
Amygdala508.1
Appendix115.65
AtrioventricularNode65.75
BDCA4+_DentriticCells152.75
Bonemarrow42.8
BronchialEpithelialCells308.7
CD105+_Endothelial166.35
CD14+_Monocytes251
CD19+_BCells(neg._sel.)88.7
CD33+_Myeloid175.8
CD34+192.35
CD4+_Tcells101.6
CD56+_NKCells180
CD71+_EarlyErythroid141.65
CD8+_Tcells98.45
CardiacMyocytes171.6
Caudatenucleus305.55
Cerebellum93.2
CerebellumPeduncles122
CiliaryGanglion51.35
CingulateCortex173.55
Colorectaladenocarcinoma139.5
DorsalRootGanglion81.55
FetalThyroid116.95
Fetalbrain697.3
Fetalliver96.95
Fetallung229.95
GlobusPallidus102.65
Heart18.65
Hypothalamus659.4
Kidney67.6
Leukemia_chronicMyelogenousK-562182.65
Leukemia_promyelocytic-HL-60102.45
Leukemialymphoblastic(MOLT-4)127.75
Liver18
Lung59.65
Lymphnode103.5
Lymphoma_burkitts(Daudi)121.4
Lymphoma_burkitts(Raji)34.4
MedullaOblongata292.45
OccipitalLobe385.75
OlfactoryBulb245.05
Ovary59.9
Pancreas124.25
PancreaticIslet151.15
ParietalLobe322.6
Pituitary181.3
Placenta98.15
Pons138.8
PrefrontalCortex413.45
Prostate177.65
Salivarygland104.5
SkeletalMuscle79.95
Skin65.85
SmoothMuscle344.35
Spinalcord780.45
SubthalamicNucleus153.9
SuperiorCervicalGanglion68.95
TemporalLobe127.9
Testis103.7
TestisGermCell150.35
TestisIntersitial118.35
TestisLeydigCell122.35
TestisSeminiferousTubule112.1
Thalamus428
Thymus82.15
Thyroid226.95
Tongue132.2
Tonsil65.35
Trachea91.5
TrigeminalGanglion63.5
Uterus221.1
UterusCorpus123.3
WholeBlood104.95
Wholebrain237.95
colon205.4
pineal_day401.76
pineal_night370.82
retina333.475
small_intestine145.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P154108
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.13 ± 0.29
Basal Forebrain9.5 ± 0.34
Basal Part of Pons9.59 ± 0.27
Cerebellar Cortex9.43 ± 0.56
Cerebellar Nuclei10.16 ± 0.36
Claustrum9.49 ± 0.36
Epithalamus9.43 ± 0.42
Frontal Lobe9.64 ± 0.37
Globus Pallidus10.29 ± 0.39
Hypothalamus9.6 ± 0.21
Insula9.5 ± 0.3
Limbic Lobe9.29 ± 0.28
Mesencephalon9.62 ± 0.47
Myelencephalon9.54 ± 0.38
Occipital Lobe9.44 ± 0.29
Parietal Lobe9.43 ± 0.32
Pontine Tegmentum9.62 ± 0.27
Striatum9.58 ± 0.26
Subthalamus9.93 ± 0.4
Temporal Lobe9.46 ± 0.27
Thalamus9.82 ± 0.26
White Matter11.19 ± 0.18
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dync1i2CBCerebellum79.83
100
Dync1i2CTXCerebral cortex100
100
Dync1i2HIPHippocampal region100
100
Dync1i2HPFHippocampal formation100
100
Dync1i2HYHypothalamus100
100
Dync1i2LSXLateral septal complex100
100
Dync1i2MBMidbrain100
100
Dync1i2MYMedulla100
100
Dync1i2OLFOlfactory bulb100
100
Dync1i2PPons100
100
Dync1i2PALPallidum100
100
Dync1i2RHPRetrohippocampal region100
100
Dync1i2sAMYStriatum-like amygdalar nuclei100
100
Dync1i2STRStriatum100
100
Dync1i2STRdStriatum dorsal region100
100
Dync1i2STRvStriatum ventral region100
100
Dync1i2THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
DC1I2_HUMAN_159 11 159 169 ETQTPVMAQPK PRIDE
DC1I2_HUMAN_2 12 2 13 SDKSELKAELER PRIDE
DC1I2_HUMAN_250 14 250 263 DLEDKEGEIQAGAK PRIDE
DC1I2_HUMAN_616 19 616 634 TLAEINANRADAEEEAATR PRIDE
DC1I2_HUMAN_91 21 91 111 SVSTPSEAGSQDSGDGAVGSR PRIDE
PAp00000751 31 431 461 AVAVTSMSFPVGDVNNFVVGSEEGSVYTACR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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