AutismKB 2.0

Annotation Detail for DYNC1LI2


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Basic Information Top
Gene Symbol:DYNC1LI2 ( DNCLI2,LIC2 )
Gene Full Name: dynein, cytoplasmic 1, light intermediate chain 2
Band: 16q22.1
Quick LinksEntrez ID:1783; OMIM: 611406; Uniprot ID:DC1L2_HUMAN; ENSEMBL ID: ENSG00000135720; HGNC ID: 2966
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body14 / 70761197
blastocyst18 / 62319288
fetus99 / 564012175
neonate0 / 310970 
infant5 / 23620211
juvenile2 / 5555635
adult245 / 1939121126
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma0 / 174750 
breast (mammary gland) tumor6 / 9417863
cervical tumor1 / 3436629
chondrosarcoma18 / 82823217
colorectal tumor9 / 11424678
esophageal tumor6 / 17290347
gastrointestinal tumor14 / 119369117
germ cell tumor22 / 26384583
glioma26 / 106883243
head and neck tumor17 / 136302124
kidney tumor8 / 68959116
leukemia7 / 9584273
liver tumor6 / 9635962
lung tumor6 / 10312758
lymphoma2 / 7175527
non-neoplasia16 / 97250164
normal576 / 3360307171
ovarian tumor7 / 7668291
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer5 / 10268048
retinoblastoma0 / 463560 
skin tumor11 / 12494988
soft tissue/muscle tissue tumor15 / 125191119
uterine tumor9 / 9025799
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland2 / 3319760
ascites6 / 40015149
bladder1 / 2975733
blood1 / 1234788
bone10 / 71655139
bone marrow4 / 4880181
brain293 / 1100989266
cervix3 / 4817162
connective tissue15 / 149255100
ear0 / 162120 
embryonic tissue48 / 215722222
esophagus6 / 20209296
eye27 / 211054127
heart24 / 89626267
intestine21 / 23447289
kidney31 / 211777146
larynx5 / 24145207
liver21 / 207743101
lung60 / 336974178
lymph2 / 4427045
lymph node17 / 91610185
mammary gland10 / 15327165
mouth9 / 67052134
muscle29 / 107715269
nerve3 / 15768190
ovary7 / 10205168
pancreas16 / 21481274
parathyroid12 / 20539584
pharynx2 / 4132848
pituitary gland1 / 1658560
placenta36 / 280825128
prostate21 / 189345110
salivary gland0 / 201550 
skin31 / 210574147
spleen5 / 5395292
stomach11 / 96619113
testis36 / 330442108
thymus16 / 81131197
thyroid7 / 47473147
tonsil0 / 169990 
trachea19 / 52413362
umbilical cord0 / 136800 
uterus32 / 232878137
vascular6 / 51780115
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203590_at
Cell line Expression level Expression bar
721_B_lymphoblasts72.1
Adipocyte192.15
AdrenalCortex134.55
Adrenalgland106.55
Amygdala614.75
Appendix105.95
AtrioventricularNode49.7
BDCA4+_DentriticCells82.55
Bonemarrow87.6
BronchialEpithelialCells148.05
CD105+_Endothelial47.9
CD14+_Monocytes82.7
CD19+_BCells(neg._sel.)45.15
CD33+_Myeloid153.4
CD34+93.1
CD4+_Tcells89.4
CD56+_NKCells56.15
CD71+_EarlyErythroid42.25
CD8+_Tcells92.9
CardiacMyocytes154.8
Caudatenucleus306.85
Cerebellum202.65
CerebellumPeduncles526.05
CiliaryGanglion76.55
CingulateCortex551.9
Colorectaladenocarcinoma91.8
DorsalRootGanglion195.65
FetalThyroid536.15
Fetalbrain285.55
Fetalliver57.7
Fetallung132.1
GlobusPallidus281.7
Heart46.7
Hypothalamus782.35
Kidney99.9
Leukemia_chronicMyelogenousK-56263.45
Leukemia_promyelocytic-HL-6043.05
Leukemialymphoblastic(MOLT-4)58.7
Liver68.65
Lung321.85
Lymphnode88.1
Lymphoma_burkitts(Daudi)65.15
Lymphoma_burkitts(Raji)92.25
MedullaOblongata641.7
OccipitalLobe643.7
OlfactoryBulb516.85
Ovary51.4
Pancreas123.25
PancreaticIslet160.5
ParietalLobe660.15
Pituitary346.25
Placenta282.95
Pons295.55
PrefrontalCortex2087.85
Prostate435.7
Salivarygland46.15
SkeletalMuscle28.35
Skin40.85
SmoothMuscle287.3
Spinalcord394.8
SubthalamicNucleus391.05
SuperiorCervicalGanglion67.05
TemporalLobe381.55
Testis129.75
TestisGermCell218.9
TestisIntersitial168.8
TestisLeydigCell106.25
TestisSeminiferousTubule178.3
Thalamus531.5
Thymus172.6
Thyroid203
Tongue105.25
Tonsil87.7
Trachea140.6
TrigeminalGanglion65.65
Uterus384.1
UterusCorpus28.1
WholeBlood35.6
Wholebrain495.15
colon493.45
pineal_day317.22
pineal_night226.08
retina610.775
small_intestine237.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P9688
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala10.92 ± 0.18
Basal Forebrain11.44 ± 0.4
Basal Part of Pons11.18 ± 0.15
Cerebellar Cortex11 ± 0.07
Cerebellar Nuclei11.57 ± 0.21
Claustrum11.23 ± 0.2
Epithalamus11.51 ± 0.23
Frontal Lobe11.18 ± 0.3
Globus Pallidus12.2 ± 0.17
Hypothalamus11.14 ± 0.26
Insula11.06 ± 0.17
Limbic Lobe11.07 ± 0.3
Mesencephalon11.37 ± 0.32
Myelencephalon11.24 ± 0.28
Occipital Lobe11.14 ± 0.3
Parietal Lobe11.2 ± 0.27
Pontine Tegmentum11.23 ± 0.3
Striatum11.44 ± 0.4
Subthalamus11.68 ± 0.42
Temporal Lobe11.19 ± 0.24
Thalamus11.32 ± 0.26
White Matter12.4 ± 0.31
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dync1li2CBCerebellum40.32
74.36
Dync1li2CTXCerebral cortex100
100
Dync1li2HIPHippocampal region59.28
99.21
Dync1li2HPFHippocampal formation81.26
100
Dync1li2HYHypothalamus59.21
59.44
Dync1li2LSXLateral septal complex82.51
73.15
Dync1li2MBMidbrain76.43
88.18
Dync1li2MYMedulla73.3
100
Dync1li2OLFOlfactory bulb78.37
85.52
Dync1li2PPons66.67
94.14
Dync1li2PALPallidum59.2
65.34
Dync1li2RHPRetrohippocampal region100
100
Dync1li2sAMYStriatum-like amygdalar nuclei77
68.29
Dync1li2STRStriatum63.89
54.11
Dync1li2STRdStriatum dorsal region60.59
51.55
Dync1li2STRvStriatum ventral region63.18
50.22
Dync1li2THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
DC1L2_HUMAN_84 19 84 102 GLEYLYLSVHDEDRDDHTR PRIDE
PAp00001245 13 104 116 CNVWILDGDLYHK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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