AutismKB 2.0

Annotation Detail for DNM2


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Basic Information Top
Gene Symbol:DNM2 ( CMT2M,CMTDI1,CMTDIB,DI-CMTB,DYN2,DYNII )
Gene Full Name: dynamin 2
Band: 19p13.2
Quick LinksEntrez ID:1785; OMIM: 602378; Uniprot ID:DYN2_HUMAN; ENSEMBL ID: ENSG00000079805; HGNC ID: 2974
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body8 / 70761113
blastocyst5 / 6231980
fetus7 / 56401212
neonate1 / 3109732
infant1 / 2362042
juvenile2 / 5555635
adult249 / 1939121128
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor14 / 94178148
cervical tumor2 / 3436658
chondrosarcoma3 / 8282336
colorectal tumor38 / 114246332
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor35 / 263845132
glioma10 / 10688393
head and neck tumor28 / 136302205
kidney tumor14 / 68959203
leukemia21 / 95842219
liver tumor11 / 96359114
lung tumor10 / 10312796
lymphoma12 / 71755167
non-neoplasia6 / 9725061
normal231 / 336030768
ovarian tumor5 / 7668265
pancreatic tumor10 / 10461695
primitive neuroectodermal tumor of the CNS16 / 125680127
prostate cancer6 / 10268058
retinoblastoma4 / 4635686
skin tumor13 / 124949104
soft tissue/muscle tissue tumor11 / 12519187
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites1 / 4001524
bladder3 / 29757100
blood27 / 123478218
bone3 / 7165541
bone marrow3 / 4880161
brain89 / 110098980
cervix4 / 4817183
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue17 / 21572278
esophagus0 / 202090 
eye10 / 21105447
heart0 / 896260 
intestine60 / 234472255
kidney23 / 211777108
larynx13 / 24145538
liver12 / 20774357
lung15 / 33697444
lymph10 / 44270225
lymph node4 / 9161043
mammary gland18 / 153271117
mouth7 / 67052104
muscle4 / 10771537
nerve2 / 15768126
ovary23 / 102051225
pancreas17 / 21481279
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta28 / 28082599
prostate11 / 18934558
salivary gland4 / 20155198
skin17 / 21057480
spleen3 / 5395255
stomach3 / 9661931
testis70 / 330442211
thymus20 / 81131246
thyroid3 / 4747363
tonsil0 / 169990 
trachea9 / 52413171
umbilical cord0 / 136800 
uterus16 / 23287868
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202253_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts20.3
Adipocyte4.7
AdrenalCortex5.15
Adrenalgland6.5
Amygdala4.85
Appendix4.75
AtrioventricularNode3.65
BDCA4+_DentriticCells101.55
Bonemarrow4.85
BronchialEpithelialCells5
CD105+_Endothelial8.8
CD14+_Monocytes33.35
CD19+_BCells(neg._sel.)8.65
CD33+_Myeloid28.15
CD34+16.95
CD4+_Tcells14.5
CD56+_NKCells34.1
CD71+_EarlyErythroid19.55
CD8+_Tcells14.6
CardiacMyocytes6.05
Caudatenucleus4.45
Cerebellum4
CerebellumPeduncles5.45
CiliaryGanglion3.4
CingulateCortex4.9
Colorectaladenocarcinoma6
DorsalRootGanglion3.65
FetalThyroid5.7
Fetalbrain4.55
Fetalliver4.2
Fetallung5.4
GlobusPallidus3.5
Heart10
Hypothalamus5.4
Kidney5.6
Leukemia_chronicMyelogenousK-56213
Leukemia_promyelocytic-HL-604.35
Leukemialymphoblastic(MOLT-4)8.35
Liver8
Lung39.45
Lymphnode5.15
Lymphoma_burkitts(Daudi)5.95
Lymphoma_burkitts(Raji)13.55
MedullaOblongata4.75
OccipitalLobe4.3
OlfactoryBulb3.7
Ovary3.15
Pancreas5.4
PancreaticIslet4.95
ParietalLobe5
Pituitary5.75
Placenta8.25
Pons4.5
PrefrontalCortex7
Prostate7.5
Salivarygland3.85
SkeletalMuscle5.5
Skin3.65
SmoothMuscle5.85
Spinalcord6.45
SubthalamicNucleus4.3
SuperiorCervicalGanglion5.35
TemporalLobe4.3
Testis4.4
TestisGermCell4.35
TestisIntersitial4.1
TestisLeydigCell4.65
TestisSeminiferousTubule4.5
Thalamus5
Thymus8.45
Thyroid10.75
Tongue4.7
Tonsil5.15
Trachea3.9
TrigeminalGanglion4.7
Uterus4.25
UterusCorpus4.25
WholeBlood13.85
Wholebrain4.25
colon6.4
pineal_day6.46
pineal_night6
retina6.6
small_intestine4.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15939_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.05 ± 0.51
Basal Forebrain5.65 ± 0.46
Basal Part of Pons5.47 ± 0.48
Cerebellar Cortex5.31 ± 0.28
Cerebellar Nuclei6.14 ± 0.47
Claustrum5.29 ± 0.35
Epithalamus5.51 ± 0.48
Frontal Lobe5.25 ± 0.54
Globus Pallidus6.69 ± 0.39
Hypothalamus5.19 ± 0.44
Insula5.1 ± 0.38
Limbic Lobe5.12 ± 0.59
Mesencephalon5.3 ± 0.68
Myelencephalon5.43 ± 0.51
Occipital Lobe5.42 ± 0.65
Parietal Lobe5.28 ± 0.52
Pontine Tegmentum5.5 ± 0.5
Striatum5.71 ± 0.62
Subthalamus5.33 ± 0.26
Temporal Lobe5.2 ± 0.4
Thalamus5.58 ± 0.52
White Matter7.58 ± 0.46
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dnm2CBCerebellum0.58
1.04
Dnm2CTXCerebral cortex1.04
1.03
Dnm2HIPHippocampal region0.81
1.23
Dnm2HPFHippocampal formation0.5
0.69
Dnm2HYHypothalamus0.09
0.09
Dnm2LSXLateral septal complex0.06
0.08
Dnm2MBMidbrain0.26
0.45
Dnm2MYMedulla0.28
0.3
Dnm2OLFOlfactory bulb2
1.96
Dnm2PPons0.28
0.39
Dnm2PALPallidum1.45
1.87
Dnm2RHPRetrohippocampal region0.05
0.03
Dnm2sAMYStriatum-like amygdalar nuclei0.06
0.09
Dnm2STRStriatum0.2
0.28
Dnm2STRdStriatum dorsal region0.27
0.33
Dnm2STRvStriatum ventral region0.09
0.36
Dnm2THThalamus0.25
0.37
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
DYN2_HUMAN_158 9 158 166 DMILQFISR PRIDE
DYN2_HUMAN_328 15 328 342 ALLQMVQQFGVDFEK PRIDE
DYN2_HUMAN_353 9 353 361 TLELSGGAR PRIDE
DYN2_HUMAN_630 22 630 651 DQAENEDGAQENTFSMDPQLER PRIDE
DYN2_HUMAN_838 12 838 849 IPPGIPPGVPSR PRIDE
DYN2_HUMAN_99 9 99 107 QEIEAETDR PRIDE
PAp00005232 29 16 44 LQDAFSSIGQSCHLDLPQIAVVGGQSAGK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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