AutismKB 2.0

Annotation Detail for DNMT1


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Basic Information Top
Gene Symbol:DNMT1 ( AIM,CXXC9,DNMT,FLJ16293,MCMT,MGC104992 )
Gene Full Name: DNA (cytosine-5-)-methyltransferase 1
Band: 19p13.2
Quick LinksEntrez ID:1786; OMIM: 126375; Uniprot ID:DNMT1_HUMAN; ENSEMBL ID: ENSG00000130816; HGNC ID: 2976
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body12 / 70761169
blastocyst10 / 62319160
fetus47 / 56401283
neonate1 / 3109732
infant0 / 236200 
juvenile2 / 5555635
adult167 / 193912186
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma0 / 174750 
breast (mammary gland) tumor15 / 94178159
cervical tumor6 / 34366174
chondrosarcoma8 / 8282396
colorectal tumor7 / 11424661
esophageal tumor0 / 172900 
gastrointestinal tumor19 / 119369159
germ cell tumor31 / 263845117
glioma8 / 10688374
head and neck tumor6 / 13630244
kidney tumor8 / 68959116
leukemia9 / 9584293
liver tumor3 / 9635931
lung tumor5 / 10312748
lymphoma15 / 71755209
non-neoplasia7 / 9725071
normal297 / 336030788
ovarian tumor6 / 7668278
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS16 / 125680127
prostate cancer5 / 10268048
retinoblastoma4 / 4635686
skin tumor9 / 12494972
soft tissue/muscle tissue tumor11 / 12519187
uterine tumor13 / 90257144
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites6 / 40015149
bladder1 / 2975733
blood18 / 123478145
bone6 / 7165583
bone marrow2 / 4880140
brain53 / 110098948
cervix10 / 48171207
connective tissue9 / 14925560
ear4 / 16212246
embryonic tissue30 / 215722139
esophagus0 / 202090 
eye8 / 21105437
heart1 / 8962611
intestine21 / 23447289
kidney13 / 21177761
larynx1 / 2414541
liver10 / 20774348
lung13 / 33697438
lymph13 / 44270293
lymph node84 / 91610916
mammary gland20 / 153271130
mouth3 / 6705244
muscle8 / 10771574
nerve1 / 1576863
ovary10 / 10205197
pancreas9 / 21481241
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta27 / 28082596
prostate7 / 18934536
salivary gland0 / 201550 
skin11 / 21057452
spleen3 / 5395255
stomach7 / 9661972
testis45 / 330442136
thymus9 / 81131110
thyroid2 / 4747342
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus22 / 23287894
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201697_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts994.9
Adipocyte33.15
AdrenalCortex19.25
Adrenalgland41.65
Amygdala64.55
Appendix9.6
AtrioventricularNode6.65
BDCA4+_DentriticCells222.45
Bonemarrow111.3
BronchialEpithelialCells81.35
CD105+_Endothelial701.1
CD14+_Monocytes118.05
CD19+_BCells(neg._sel.)94.45
CD33+_Myeloid273.2
CD34+903.55
CD4+_Tcells619.95
CD56+_NKCells360.7
CD71+_EarlyErythroid416.75
CD8+_Tcells632.15
CardiacMyocytes74.35
Caudatenucleus35.6
Cerebellum69.6
CerebellumPeduncles107.5
CiliaryGanglion6.25
CingulateCortex33.3
Colorectaladenocarcinoma368
DorsalRootGanglion6.95
FetalThyroid29.45
Fetalbrain61.15
Fetalliver75.75
Fetallung75.15
GlobusPallidus30.6
Heart49.65
Hypothalamus88.2
Kidney11.65
Leukemia_chronicMyelogenousK-562386.1
Leukemia_promyelocytic-HL-60898.7
Leukemialymphoblastic(MOLT-4)644.6
Liver21.65
Lung230
Lymphnode144.75
Lymphoma_burkitts(Daudi)748.5
Lymphoma_burkitts(Raji)1707.8
MedullaOblongata33.9
OccipitalLobe46.4
OlfactoryBulb29
Ovary9.95
Pancreas27.15
PancreaticIslet24
ParietalLobe32.3
Pituitary37.5
Placenta242.25
Pons15.4
PrefrontalCortex54.4
Prostate115.55
Salivarygland37.25
SkeletalMuscle10.2
Skin6.4
SmoothMuscle69.6
Spinalcord50.55
SubthalamicNucleus27.9
SuperiorCervicalGanglion10.35
TemporalLobe15
Testis199.1
TestisGermCell149.25
TestisIntersitial73.95
TestisLeydigCell58.1
TestisSeminiferousTubule74.9
Thalamus40.5
Thymus387.35
Thyroid68.2
Tongue20.6
Tonsil223.5
Trachea19.75
TrigeminalGanglion37.1
Uterus76.5
UterusCorpus19.65
WholeBlood97.15
Wholebrain74.25
colon77.9
pineal_day80.32
pineal_night94.64
retina63.25
small_intestine105.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P408083
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.97 ± 0.58
Basal Forebrain4.27 ± 0.34
Basal Part of Pons4.24 ± 0.53
Cerebellar Cortex4.81 ± 0.41
Cerebellar Nuclei4.18 ± 0.44
Claustrum3.84 ± 0.92
Epithalamus4.38 ± 0.57
Frontal Lobe4.35 ± 0.61
Globus Pallidus3.81 ± 0.18
Hypothalamus4.42 ± 0.67
Insula4.16 ± 0.58
Limbic Lobe4.02 ± 0.56
Mesencephalon4.21 ± 0.58
Myelencephalon4.24 ± 0.58
Occipital Lobe4.11 ± 0.5
Parietal Lobe4.18 ± 0.54
Pontine Tegmentum4.28 ± 0.58
Striatum3.81 ± 0.52
Subthalamus4.33 ± 0.13
Temporal Lobe4.35 ± 0.51
Thalamus4.3 ± 0.55
White Matter4.39 ± 0.28
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dnmt1CBCerebellum84.44
100
Dnmt1CTXCerebral cortex88.89
71.8
Dnmt1HIPHippocampal region46.86
66.86
Dnmt1HPFHippocampal formation57.24
65.28
Dnmt1HYHypothalamus66.31
53.29
Dnmt1LSXLateral septal complex59.14
48.61
Dnmt1MBMidbrain56.58
50.42
Dnmt1MYMedulla55.74
61.03
Dnmt1OLFOlfactory bulb98.8
98.99
Dnmt1PPons51.14
52.88
Dnmt1PALPallidum55.88
49.24
Dnmt1RHPRetrohippocampal region75.64
63.85
Dnmt1sAMYStriatum-like amygdalar nuclei84.32
66.44
Dnmt1STRStriatum46.59
35.94
Dnmt1STRdStriatum dorsal region30.16
22.5
Dnmt1STRvStriatum ventral region72.81
51.99
Dnmt1THThalamus52.43
44.04
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
DNMT1_HUMAN_1300 11 1300 1310 QAGQYGVAQTR PRIDE
DNMT1_HUMAN_1416 9 1416 1424 DMSALVAAR PRIDE
DNMT1_HUMAN_288 10 288 297 SQPKDLAAKR PRIDE
PAp00000232 12 1338 1349 ACQLSVVVDDKK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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