AutismKB 2.0

Annotation Detail for DNMT3A


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Basic Information Top
Gene Symbol:DNMT3A ( DNMT3A2,M.HsaIIIA )
Gene Full Name: DNA (cytosine-5-)-methyltransferase 3 alpha
Band: 2p23.3
Quick LinksEntrez ID:1788; OMIM: 602769; Uniprot ID:DNM3A_HUMAN; ENSEMBL ID: ENSG00000119772; HGNC ID: 2978
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst15 / 62319240
fetus24 / 56401242
neonate0 / 310970 
infant0 / 236200 
juvenile3 / 5555653
adult111 / 193912157
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma1 / 8282312
colorectal tumor49 / 114246428
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor32 / 263845121
glioma1 / 1068839
head and neck tumor13 / 13630295
kidney tumor1 / 6895914
leukemia5 / 9584252
liver tumor4 / 9635941
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia1 / 9725010
normal99 / 336030729
ovarian tumor2 / 7668226
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer0 / 1026800 
retinoblastoma5 / 46356107
skin tumor2 / 12494916
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood6 / 12347848
bone0 / 716550 
bone marrow0 / 488010 
brain8 / 11009897
cervix2 / 4817141
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue24 / 215722111
esophagus0 / 202090 
eye11 / 21105452
heart7 / 8962678
intestine53 / 234472226
kidney1 / 2117774
larynx13 / 24145538
liver5 / 20774324
lung8 / 33697423
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth1 / 6705214
muscle2 / 10771518
nerve1 / 1576863
ovary4 / 10205139
pancreas4 / 21481218
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta13 / 28082546
prostate1 / 1893455
salivary gland0 / 201550 
skin3 / 21057414
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218457_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.05
Adipocyte4
AdrenalCortex4.25
Adrenalgland3.45
Amygdala4.2
Appendix4.2
AtrioventricularNode3.2
BDCA4+_DentriticCells4.35
Bonemarrow4.05
BronchialEpithelialCells4
CD105+_Endothelial4.15
CD14+_Monocytes4.3
CD19+_BCells(neg._sel.)4.35
CD33+_Myeloid5.25
CD34+5.2
CD4+_Tcells4.45
CD56+_NKCells4.9
CD71+_EarlyErythroid3.8
CD8+_Tcells3.95
CardiacMyocytes5.45
Caudatenucleus3.65
Cerebellum3.3
CerebellumPeduncles4.65
CiliaryGanglion2.9
CingulateCortex4.2
Colorectaladenocarcinoma4.05
DorsalRootGanglion3.1
FetalThyroid3.95
Fetalbrain4.05
Fetalliver3.55
Fetallung3.4
GlobusPallidus2.95
Heart5.1
Hypothalamus4.4
Kidney3.35
Leukemia_chronicMyelogenousK-5623.7
Leukemia_promyelocytic-HL-603.6
Leukemialymphoblastic(MOLT-4)3.25
Liver5.4
Lung4.5
Lymphnode3.5
Lymphoma_burkitts(Daudi)5.25
Lymphoma_burkitts(Raji)5.7
MedullaOblongata3.7
OccipitalLobe3.65
OlfactoryBulb3.2
Ovary2.75
Pancreas3.25
PancreaticIslet4.35
ParietalLobe4.35
Pituitary4.75
Placenta4.3
Pons3.9
PrefrontalCortex5.05
Prostate4.75
Salivarygland3.25
SkeletalMuscle4.75
Skin3.2
SmoothMuscle4.6
Spinalcord4.35
SubthalamicNucleus3.75
SuperiorCervicalGanglion4.7
TemporalLobe3.7
Testis3.5
TestisGermCell3.4
TestisIntersitial3.4
TestisLeydigCell4
TestisSeminiferousTubule3.5
Thalamus4.15
Thymus3.25
Thyroid5.05
Tongue4.05
Tonsil3.95
Trachea3.4
TrigeminalGanglion4.15
Uterus3.35
UterusCorpus3.7
WholeBlood4.5
Wholebrain3.35
colon4.1
pineal_day5.06
pineal_night4.94
retina4.9
small_intestine3.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_13533_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.62 ± 0.67
Basal Forebrain5.36 ± 0.2
Basal Part of Pons4.97 ± 0.36
Cerebellar Cortex5.14 ± 0.33
Cerebellar Nuclei5.34 ± 0.39
Claustrum5.63 ± 0.68
Epithalamus5.17 ± 0.5
Frontal Lobe4.9 ± 0.46
Globus Pallidus5.64 ± 0.32
Hypothalamus5.1 ± 0.33
Insula4.98 ± 0.47
Limbic Lobe5.35 ± 0.67
Mesencephalon5.33 ± 0.49
Myelencephalon5.24 ± 0.59
Occipital Lobe5.7 ± 0.69
Parietal Lobe5.25 ± 0.52
Pontine Tegmentum5.22 ± 0.67
Striatum6.07 ± 0.64
Subthalamus4.82 ± 0.3
Temporal Lobe5.06 ± 0.44
Thalamus5.08 ± 0.44
White Matter6.21 ± 0.47
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dnmt3aCBCerebellum5.32
6.56
Dnmt3aCTXCerebral cortex13.86
8.65
Dnmt3aHIPHippocampal region6.04
5.71
Dnmt3aHPFHippocampal formation5.34
4.43
Dnmt3aHYHypothalamus6.37
4.42
Dnmt3aLSXLateral septal complex1.72
1.27
Dnmt3aMBMidbrain5.45
4.58
Dnmt3aMYMedulla21.85
20.38
Dnmt3aOLFOlfactory bulb19.76
14.64
Dnmt3aPPons10.74
9.29
Dnmt3aPALPallidum6.68
4.95
Dnmt3aRHPRetrohippocampal region4.14
2.67
Dnmt3asAMYStriatum-like amygdalar nuclei2.66
1.55
Dnmt3aSTRStriatum12.34
7.78
Dnmt3aSTRdStriatum dorsal region13.66
8.63
Dnmt3aSTRvStriatum ventral region20.97
12.65
Dnmt3aTHThalamus6.68
4.96
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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