AutismKB 2.0

Annotation Detail for DNTT


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Basic Information Top
Gene Symbol:DNTT ( TDT )
Gene Full Name: deoxynucleotidyltransferase, terminal
Band: 10q24.1
Quick LinksEntrez ID:1791; OMIM: 187410; Uniprot ID:TDT_HUMAN; ENSEMBL ID: ENSG00000107447; HGNC ID: 2983
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus0 / 5640120 
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult0 / 19391210 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor4 / 26384515
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia9 / 9584293
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal1 / 33603070 
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood8 / 12347864
bone0 / 716550 
bone marrow0 / 488010 
brain0 / 11009890 
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node1 / 9161010
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus56 / 81131690
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210487_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.9
Adipocyte5.9
AdrenalCortex6.75
Adrenalgland5.3
Amygdala6.1
Appendix6.25
AtrioventricularNode5.15
BDCA4+_DentriticCells5.85
Bonemarrow6.5
BronchialEpithelialCells5.75
CD105+_Endothelial381.7
CD14+_Monocytes6.2
CD19+_BCells(neg._sel.)6.2
CD33+_Myeloid7.1
CD34+750.35
CD4+_Tcells5.9
CD56+_NKCells8.7
CD71+_EarlyErythroid6.05
CD8+_Tcells5.05
CardiacMyocytes9.15
Caudatenucleus5.3
Cerebellum5
CerebellumPeduncles7.05
CiliaryGanglion6.9
CingulateCortex6.2
Colorectaladenocarcinoma8.6
DorsalRootGanglion4.95
FetalThyroid5.9
Fetalbrain5.8
Fetalliver5.55
Fetallung4.9
GlobusPallidus4.6
Heart9.2
Hypothalamus6.25
Kidney5.2
Leukemia_chronicMyelogenousK-5625.5
Leukemia_promyelocytic-HL-605.3
Leukemialymphoblastic(MOLT-4)624.95
Liver9.05
Lung6.55
Lymphnode4.9
Lymphoma_burkitts(Daudi)8.15
Lymphoma_burkitts(Raji)9.3
MedullaOblongata5.4
OccipitalLobe5.4
OlfactoryBulb4.7
Ovary4.2
Pancreas4.9
PancreaticIslet6.65
ParietalLobe7.5
Pituitary7.15
Placenta6.05
Pons5.85
PrefrontalCortex7.4
Prostate7.7
Salivarygland4.95
SkeletalMuscle9.15
Skin5.6
SmoothMuscle6.8
Spinalcord6.55
SubthalamicNucleus5.5
SuperiorCervicalGanglion7.9
TemporalLobe5.75
Testis5.25
TestisGermCell4.8
TestisIntersitial5.15
TestisLeydigCell6.15
TestisSeminiferousTubule5.15
Thalamus6.25
Thymus381.15
Thyroid8.55
Tongue6.2
Tonsil5.95
Trachea5.1
TrigeminalGanglion7.25
Uterus4.95
UterusCorpus5.65
WholeBlood6.45
Wholebrain4.9
colon6
pineal_day7.12
pineal_night7
retina7.5
small_intestine5.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7677_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.33 ± 0.94
Basal Forebrain1.89 ± 0.25
Basal Part of Pons1.56 ± 0.51
Cerebellar Cortex1.58 ± 0.68
Cerebellar Nuclei2.09 ± 0.76
Claustrum2.8 ± 0.96
Epithalamus1.56 ± 0.71
Frontal Lobe1.67 ± 0.65
Globus Pallidus2.38 ± 0.43
Hypothalamus1.96 ± 0.65
Insula1.61 ± 0.46
Limbic Lobe1.8 ± 0.67
Mesencephalon1.99 ± 0.68
Myelencephalon1.8 ± 0.63
Occipital Lobe1.79 ± 0.59
Parietal Lobe1.86 ± 0.8
Pontine Tegmentum1.9 ± 0.85
Striatum2.04 ± 0.74
Subthalamus1.91 ± 0.68
Temporal Lobe1.74 ± 0.74
Thalamus1.78 ± 0.64
White Matter2.18 ± 0.37
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
DnttCBCerebellum1.01
1.29
DnttCTXCerebral cortex0.9
0.53
DnttHIPHippocampal region0.34
0.43
DnttHPFHippocampal formation0.47
0.44
DnttHYHypothalamus0.45
0.33
DnttLSXLateral septal complex0.1
0
DnttMBMidbrain0.94
1.01
DnttMYMedulla0.48
0.43
DnttOLFOlfactory bulb2.28
2.39
DnttPPons0.68
0.4
DnttPALPallidum0.39
0.26
DnttRHPRetrohippocampal region0.66
0.49
DnttsAMYStriatum-like amygdalar nuclei0.44
0.34
DnttSTRStriatum0.25
0.26
DnttSTRdStriatum dorsal region0.24
0.32
DnttSTRvStriatum ventral region0.19
0.13
DnttTHThalamus0.5
0.4
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018