Annotation Detail for DOCK1
Basic Information Top
| Gene Symbol: | DOCK1 ( DOCK180,ced5 ) |
|---|---|
| Gene Full Name: | dedicator of cytokinesis 1 |
| Band: | 10q26.2 |
| Quick Links | Entrez ID:1793; OMIM: 601403; Uniprot ID:DOCK1_HUMAN; ENSEMBL ID: ENSG00000150760; HGNC ID: 2987 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.159195
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 8 / 70761 | 113 |  |
| blastocyst | 7 / 62319 | 112 | |
| fetus | 24 / 564012 | 42 |  |
| neonate | 0 / 31097 | 0 | |
| infant | 1 / 23620 | 42 | |
| juvenile | 0 / 55556 | 0 | |
| adult | 107 / 1939121 | 55 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 1 / 12794 | 78 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 5 / 94178 | 53 | |
| cervical tumor | 3 / 34366 | 87 | |
| chondrosarcoma | 9 / 82823 | 108 | |
| colorectal tumor | 13 / 114246 | 113 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 6 / 119369 | 50 | |
| germ cell tumor | 8 / 263845 | 30 | |
| glioma | 4 / 106883 | 37 | |
| head and neck tumor | 11 / 136302 | 80 | |
| kidney tumor | 5 / 68959 | 72 | |
| leukemia | 1 / 95842 | 10 |  |
| liver tumor | 2 / 96359 | 20 | |
| lung tumor | 2 / 103127 | 19 | |
| lymphoma | 0 / 71755 | 0 | |
| non-neoplasia | 2 / 97250 | 20 | |
| normal | 146 / 3360307 | 43 | |
| ovarian tumor | 2 / 76682 | 26 | |
| pancreatic tumor | 4 / 104616 | 38 | |
| primitive neuroectodermal tumor of the CNS | 0 / 125680 | 0 | |
| prostate cancer | 1 / 102680 | 9 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 2 / 124949 | 16 | |
| soft tissue/muscle tissue tumor | 4 / 125191 | 31 | |
| uterine tumor | 4 / 90257 | 44 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 1 / 13106 | 76 | |
| adrenal gland | 2 / 33197 | 60 | |
| ascites | 1 / 40015 | 24 | |
| bladder | 1 / 29757 | 33 | |
| blood | 0 / 123478 | 0 | |
| bone | 6 / 71655 | 83 | |
| bone marrow | 0 / 48801 | 0 | |
| brain | 37 / 1100989 | 33 | |
| cervix | 3 / 48171 | 62 | |
| connective tissue | 6 / 149255 | 40 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 17 / 215722 | 78 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 4 / 211054 | 18 | |
| heart | 4 / 89626 | 44 | |
| intestine | 18 / 234472 | 76 | |
| kidney | 17 / 211777 | 80 | |
| larynx | 2 / 24145 | 82 | |
| liver | 4 / 207743 | 19 | |
| lung | 7 / 336974 | 20 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 0 / 91610 | 0 | |
| mammary gland | 7 / 153271 | 45 | |
| mouth | 9 / 67052 | 134 | |
| muscle | 4 / 107715 | 37 | |
| nerve | 1 / 15768 | 63 | |
| ovary | 4 / 102051 | 39 | |
| pancreas | 18 / 214812 | 83 | |
| parathyroid | 3 / 20539 | 146 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 13 / 280825 | 46 | |
| prostate | 6 / 189345 | 31 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 6 / 210574 | 28 | |
| spleen | 1 / 53952 | 18 | |
| stomach | 4 / 96619 | 41 | |
| testis | 6 / 330442 | 18 | |
| thymus | 2 / 81131 | 24 | |
| thyroid | 0 / 47473 | 0 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 2 / 52413 | 38 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 11 / 232878 | 47 | |
| vascular | 6 / 51780 | 115 | |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 203187_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 15.5 | |
| Adipocyte | 45.55 | |
| AdrenalCortex | 23.9 | |
| Adrenalgland | 29.1 | |
| Amygdala | 41.35 | |
| Appendix | 36.8 | |
| AtrioventricularNode | 22.2 | |
| BDCA4+_DentriticCells | 16.15 | |
| Bonemarrow | 21.6 | |
| BronchialEpithelialCells | 19.55 | |
| CD105+_Endothelial | 24.15 | |
| CD14+_Monocytes | 11.55 | |
| CD19+_BCells(neg._sel.) | 11 | |
| CD33+_Myeloid | 27.7 | |
| CD34+ | 28.5 | |
| CD4+_Tcells | 11.3 | |
| CD56+_NKCells | 8.7 | |
| CD71+_EarlyErythroid | 16.65 | |
| CD8+_Tcells | 11.9 | |
| CardiacMyocytes | 32.5 | |
| Caudatenucleus | 60.9 | |
| Cerebellum | 31.1 | |
| CerebellumPeduncles | 24.65 | |
| CiliaryGanglion | 16.1 | |
| CingulateCortex | 44.15 | |
| Colorectaladenocarcinoma | 25.35 | |
| DorsalRootGanglion | 19.9 | |
| FetalThyroid | 29.25 | |
| Fetalbrain | 20.25 | |
| Fetalliver | 22.25 | |
| Fetallung | 27.1 | |
| GlobusPallidus | 20.8 | |
| Heart | 20.95 | |
| Hypothalamus | 39.4 | |
| Kidney | 42.1 | |
| Leukemia_chronicMyelogenousK-562 | 13.05 | |
| Leukemia_promyelocytic-HL-60 | 14 | |
| Leukemialymphoblastic(MOLT-4) | 14.35 | |
| Liver | 21.2 | |
| Lung | 19.75 | |
| Lymphnode | 22.55 | |
| Lymphoma_burkitts(Daudi) | 22.5 | |
| Lymphoma_burkitts(Raji) | 25.75 | |
| MedullaOblongata | 55.1 | |
| OccipitalLobe | 40.75 | |
| OlfactoryBulb | 123.55 | |
| Ovary | 17 | |
| Pancreas | 12.2 | |
| PancreaticIslet | 27.75 | |
| ParietalLobe | 45.85 | |
| Pituitary | 24.9 | |
| Placenta | 43.4 | |
| Pons | 25.75 | |
| PrefrontalCortex | 61.8 | |
| Prostate | 41.1 | |
| Salivarygland | 35.55 | |
| SkeletalMuscle | 26.35 | |
| Skin | 21.4 | |
| SmoothMuscle | 55.65 | |
| Spinalcord | 104.8 | |
| SubthalamicNucleus | 37.55 | |
| SuperiorCervicalGanglion | 43.3 | |
| TemporalLobe | 31.6 | |
| Testis | 18.9 | |
| TestisGermCell | 22.4 | |
| TestisIntersitial | 15.4 | |
| TestisLeydigCell | 22.8 | |
| TestisSeminiferousTubule | 16.2 | |
| Thalamus | 60.65 | |
| Thymus | 14.6 | |
| Thyroid | 65.1 | |
| Tongue | 25.1 | |
| Tonsil | 17 | |
| Trachea | 32.1 | |
| TrigeminalGanglion | 31.65 | |
| Uterus | 40.75 | |
| UterusCorpus | 33.45 | |
| WholeBlood | 8.25 | |
| Wholebrain | 21.75 | |
| colon | 28.65 | |
| pineal_day | 43.82 | |
| pineal_night | 43.98 | |
| retina | 44.575 | |
| small_intestine | 29.5 | |
- Probe name: CUST_12270_PI416261804
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 3.83 ± 0.62 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 4.62 ± 0.59 | |
| Basal Part of Pons | 3.07 ± 0.61 | |
| Cerebellar Cortex | 3.19 ± 0.56 | |
| Cerebellar Nuclei | 4.58 ± 0.73 | |
| Claustrum | 4.17 ± 0.96 | |
| Epithalamus | 3.89 ± 0.57 | |
| Frontal Lobe | 3.59 ± 0.84 | |
| Globus Pallidus | 5.53 ± 0.3 | |
| Hypothalamus | 3.71 ± 0.77 | |
| Insula | 3.04 ± 0.72 | |
| Limbic Lobe | 3.44 ± 0.91 | |
| Mesencephalon | 4.18 ± 0.77 | |
| Myelencephalon | 3.86 ± 0.8 | |
| Occipital Lobe | 3.96 ± 0.77 | |
| Parietal Lobe | 3.67 ± 0.86 | |
| Pontine Tegmentum | 3.94 ± 0.76 | |
| Striatum | 4.58 ± 0.66 | |
| Subthalamus | 3.7 ± 0.3 | |
| Temporal Lobe | 3.58 ± 0.75 | |
| Thalamus | 4.24 ± 0.54 | |
| White Matter | 5.92 ± 0.6 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Dock1 | CB | Cerebellum | 46.98 | |
| 62.79 | | |||
| Dock1 | CTX | Cerebral cortex | 57.6 | |
| 42.23 | | |||
| Dock1 | HIP | Hippocampal region | 38.72 | |
| 44.43 | | |||
| Dock1 | HPF | Hippocampal formation | 48.71 | |
| 46.55 | | |||
| Dock1 | HY | Hypothalamus | 45.6 | |
| 43.57 | | |||
| Dock1 | LSX | Lateral septal complex | 65.28 | |
| 47.71 | | |||
| Dock1 | MB | Midbrain | 31.45 | |
| 27.34 | | |||
| Dock1 | MY | Medulla | 32.23 | |
| 33.54 | | |||
| Dock1 | OLF | Olfactory bulb | 76.49 | |
| 65.84 | | |||
| Dock1 | P | Pons | 34.06 | |
| 34.78 | | |||
| Dock1 | PAL | Pallidum | 42.63 | |
| 38.87 | | |||
| Dock1 | RHP | Retrohippocampal region | 67.22 | |
| 50.94 | | |||
| Dock1 | sAMY | Striatum-like amygdalar nuclei | 54.32 | |
| 38.61 | | |||
| Dock1 | STR | Striatum | 43.97 | |
| 32.75 | | |||
| Dock1 | STRd | Striatum dorsal region | 34.84 | |
| 25.54 | | |||
| Dock1 | STRv | Striatum ventral region | 63.16 | |
| 47.86 | | |||
| Dock1 | TH | Thalamus | 32.8 | |
| 27.25 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| DOCK1_HUMAN_412 | 14 | 412 | 425 | KTGFPEIIMPGDVR | PRIDE |
| PAp00498326 | 29 | 1806 | 1834 | GSVADYGNLMENQDLLGSPTPPPPPPHQR | Peptide Atlas |