AutismKB 2.0

Annotation Detail for DOCK2


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Basic Information Top
Gene Symbol:DOCK2 ( FLJ46592,KIAA0209 )
Gene Full Name: dedicator of cytokinesis 2
Band: 5q35.1
Quick LinksEntrez ID:1794; OMIM: 603122; Uniprot ID:DOCK2_HUMAN; ENSEMBL ID: ENSG00000134516; HGNC ID: 2988
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus16 / 56401228
neonate0 / 310970 
infant0 / 236200 
juvenile4 / 5555671
adult45 / 193912123
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor3 / 26384511
glioma1 / 1068839
head and neck tumor2 / 13630214
kidney tumor1 / 6895914
leukemia16 / 95842166
liver tumor1 / 9635910
lung tumor5 / 10312748
lymphoma15 / 71755209
non-neoplasia3 / 9725030
normal64 / 336030719
ovarian tumor0 / 766820 
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites0 / 400150 
bladder0 / 297570 
blood17 / 123478137
bone2 / 7165527
bone marrow0 / 488010 
brain13 / 110098911
cervix0 / 481710 
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye2 / 2110549
heart0 / 896260 
intestine3 / 23447212
kidney2 / 2117779
larynx0 / 241450 
liver2 / 2077439
lung13 / 33697438
lymph10 / 44270225
lymph node21 / 91610229
mammary gland3 / 15327119
mouth2 / 6705229
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate2 / 18934510
salivary gland0 / 201550 
skin0 / 2105740 
spleen1 / 5395218
stomach1 / 9661910
testis1 / 3304423
thymus15 / 81131184
thyroid0 / 474730 
tonsil2 / 16999117
trachea2 / 5241338
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 213160_at
Cell line Expression level Expression bar
721_B_lymphoblasts821.1
Adipocyte6.1
AdrenalCortex7.1
Adrenalgland5.6
Amygdala6.5
Appendix6.8
AtrioventricularNode5.55
BDCA4+_DentriticCells917.05
Bonemarrow81.1
BronchialEpithelialCells5.95
CD105+_Endothelial18.45
CD14+_Monocytes922.1
CD19+_BCells(neg._sel.)551.85
CD33+_Myeloid1082.55
CD34+487.15
CD4+_Tcells493.75
CD56+_NKCells549.55
CD71+_EarlyErythroid6.05
CD8+_Tcells474.05
CardiacMyocytes9.2
Caudatenucleus5.65
Cerebellum5.15
CerebellumPeduncles7.4
CiliaryGanglion4.75
CingulateCortex6.45
Colorectaladenocarcinoma6.25
DorsalRootGanglion5.05
FetalThyroid6.15
Fetalbrain5.9
Fetalliver5.55
Fetallung7.35
GlobusPallidus4.8
Heart9.45
Hypothalamus6.75
Kidney5.3
Leukemia_chronicMyelogenousK-56257
Leukemia_promyelocytic-HL-60105.85
Leukemialymphoblastic(MOLT-4)140.1
Liver9.7
Lung25.2
Lymphnode165.3
Lymphoma_burkitts(Daudi)247.85
Lymphoma_burkitts(Raji)128.85
MedullaOblongata5.6
OccipitalLobe5.65
OlfactoryBulb5.1
Ovary4.25
Pancreas5.1
PancreaticIslet6.85
ParietalLobe6.75
Pituitary7.45
Placenta6.4
Pons6.1
PrefrontalCortex7.55
Prostate7.4
Salivarygland7.75
SkeletalMuscle8.3
Skin5.3
SmoothMuscle7.05
Spinalcord6.9
SubthalamicNucleus5.75
SuperiorCervicalGanglion7.95
TemporalLobe5.8
Testis5.35
TestisGermCell5.05
TestisIntersitial5.2
TestisLeydigCell6.3
TestisSeminiferousTubule5.3
Thalamus6.55
Thymus121.25
Thyroid7.8
Tongue6.45
Tonsil81.45
Trachea5.25
TrigeminalGanglion6.5
Uterus5.05
UterusCorpus5.75
WholeBlood406.4
Wholebrain5.2
colon6.35
pineal_day7.64
pineal_night7.46
retina7.55
small_intestine9.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P263653
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.6 ± 1.05
Basal Forebrain2.44 ± 0.7
Basal Part of Pons2.19 ± 0.39
Cerebellar Cortex2.05 ± 0.66
Cerebellar Nuclei2.85 ± 0.64
Claustrum2.73 ± 0.65
Epithalamus2.59 ± 0.57
Frontal Lobe2.2 ± 0.74
Globus Pallidus3.37 ± 0.48
Hypothalamus2.35 ± 0.75
Insula2.34 ± 0.95
Limbic Lobe2.3 ± 0.76
Mesencephalon2.45 ± 0.7
Myelencephalon2.31 ± 0.63
Occipital Lobe2.26 ± 0.72
Parietal Lobe2.25 ± 0.64
Pontine Tegmentum2.24 ± 0.73
Striatum2.55 ± 0.73
Subthalamus2.21 ± 0.64
Temporal Lobe2.25 ± 0.72
Thalamus2.22 ± 0.6
White Matter3.3 ± 0.55
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dock2CBCerebellum2.03
1.83
Dock2CTXCerebral cortex4.58
1.41
Dock2HIPHippocampal region5.43
3.41
Dock2HPFHippocampal formation4.95
2.59
Dock2HYHypothalamus1.28
0.47
Dock2LSXLateral septal complex0.05
0
Dock2MBMidbrain1.11
0.65
Dock2MYMedulla2.54
1.58
Dock2OLFOlfactory bulb7.81
4.32
Dock2PPons1.86
1.23
Dock2PALPallidum2.64
0.77
Dock2RHPRetrohippocampal region3.72
1.27
Dock2sAMYStriatum-like amygdalar nuclei1.28
0.63
Dock2STRStriatum1.24
0.44
Dock2STRdStriatum dorsal region0.73
0.34
Dock2STRvStriatum ventral region3.27
0.81
Dock2THThalamus1.68
0.7
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
DOCK2_HUMAN_384 10 384 393 MLVGDIIQIR PRIDE
DOCK2_HUMAN_410 14 410 423 KLGFPEIIMPGDVR PRIDE
DOCK2_HUMAN_411 13 411 423 LGFPEIIMPGDVR PRIDE
DOCK2_HUMAN_610 12 610 621 LTQNVGLLGLLK PRIDE
PAp00002208 27 10 36 ERHGVAIYNFQGSGAPQLSLQIGDVVR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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