AutismKB 2.0

Annotation Detail for DPYD


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Basic Information Top
Gene Symbol:DPYD ( DHP,DHPDHASE,DPD,MGC132008,MGC70799 )
Gene Full Name: dihydropyrimidine dehydrogenase
Band: 1p21.3
Quick LinksEntrez ID:1806; OMIM: 612779; Uniprot ID:DPYD_HUMAN; ENSEMBL ID: ENSG00000188641; HGNC ID: 3012
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst1 / 6231916
fetus5 / 5640128
neonate3 / 3109796
infant0 / 236200 
juvenile2 / 5555635
adult57 / 193912129
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma2 / 8282324
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor3 / 26384511
glioma1 / 1068839
head and neck tumor8 / 13630258
kidney tumor0 / 689590 
leukemia3 / 9584231
liver tumor3 / 9635931
lung tumor0 / 1031270 
lymphoma3 / 7175541
non-neoplasia4 / 9725041
normal77 / 336030722
ovarian tumor4 / 7668252
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor13 / 125191103
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone3 / 7165541
bone marrow2 / 4880140
brain16 / 110098914
cervix1 / 4817120
connective tissue7 / 14925546
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye3 / 21105414
heart1 / 8962611
intestine5 / 23447221
kidney4 / 21177718
larynx1 / 2414541
liver12 / 20774357
lung3 / 3369748
lymph1 / 4427022
lymph node7 / 9161076
mammary gland1 / 1532716
mouth2 / 6705229
muscle4 / 10771537
nerve2 / 15768126
ovary4 / 10205139
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx5 / 41328120
pituitary gland0 / 165850 
placenta7 / 28082524
prostate3 / 18934515
salivary gland0 / 201550 
skin4 / 21057418
spleen1 / 5395218
stomach0 / 966190 
testis6 / 33044218
thymus3 / 8113136
thyroid1 / 4747321
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord0 / 136800 
uterus14 / 23287860
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204646_at
Cell line Expression level Expression bar
721_B_lymphoblasts16.3
Adipocyte16.3
AdrenalCortex10.05
Adrenalgland7.2
Amygdala7.8
Appendix10.3
AtrioventricularNode7.95
BDCA4+_DentriticCells25.25
Bonemarrow8.75
BronchialEpithelialCells7.2
CD105+_Endothelial8.8
CD14+_Monocytes399.55
CD19+_BCells(neg._sel.)8.3
CD33+_Myeloid521.1
CD34+11
CD4+_Tcells24.2
CD56+_NKCells17.35
CD71+_EarlyErythroid7.45
CD8+_Tcells40.3
CardiacMyocytes13.55
Caudatenucleus6.85
Cerebellum6.3
CerebellumPeduncles9.2
CiliaryGanglion7.1
CingulateCortex8.1
Colorectaladenocarcinoma7.6
DorsalRootGanglion7.25
FetalThyroid8.1
Fetalbrain7.7
Fetalliver215.55
Fetallung13.8
GlobusPallidus6.15
Heart12.65
Hypothalamus7.95
Kidney7.15
Leukemia_chronicMyelogenousK-5626.85
Leukemia_promyelocytic-HL-607.1
Leukemialymphoblastic(MOLT-4)8.6
Liver13.1
Lung8.6
Lymphnode43
Lymphoma_burkitts(Daudi)10.3
Lymphoma_burkitts(Raji)11.85
MedullaOblongata6.85
OccipitalLobe6.75
OlfactoryBulb5.95
Ovary5.95
Pancreas6.6
PancreaticIslet10.85
ParietalLobe8.55
Pituitary9.15
Placenta7.3
Pons7.55
PrefrontalCortex9.25
Prostate11.1
Salivarygland10.5
SkeletalMuscle11.9
Skin7.25
SmoothMuscle9.4
Spinalcord8.75
SubthalamicNucleus7.4
SuperiorCervicalGanglion12.05
TemporalLobe7.25
Testis6.5
TestisGermCell6.2
TestisIntersitial6.6
TestisLeydigCell7.9
TestisSeminiferousTubule6.75
Thalamus8
Thymus6.6
Thyroid47.75
Tongue8.75
Tonsil7.85
Trachea9.1
TrigeminalGanglion9.8
Uterus57.1
UterusCorpus8
WholeBlood493.3
Wholebrain5.85
colon34.2
pineal_day397.22
pineal_night76.8
retina10.525
small_intestine41.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P410610
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.07 ± 0.89
Basal Forebrain2.39 ± 0.29
Basal Part of Pons2.24 ± 0.6
Cerebellar Cortex2.08 ± 0.44
Cerebellar Nuclei2.77 ± 0.81
Claustrum3.05 ± 0.52
Epithalamus2.35 ± 0.76
Frontal Lobe2.47 ± 0.84
Globus Pallidus3.36 ± 0.51
Hypothalamus2.89 ± 0.68
Insula2.67 ± 0.89
Limbic Lobe2.57 ± 0.66
Mesencephalon2.75 ± 0.79
Myelencephalon2.53 ± 0.72
Occipital Lobe2.44 ± 0.7
Parietal Lobe2.44 ± 0.66
Pontine Tegmentum2.69 ± 0.74
Striatum2.78 ± 0.64
Subthalamus2.62 ± 0.72
Temporal Lobe2.52 ± 0.74
Thalamus2.35 ± 0.71
White Matter5.38 ± 0.3
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
DpydCBCerebellum0.55
1.15
DpydCTXCerebral cortex1.45
2.46
DpydHIPHippocampal region2.76
3.23
DpydHPFHippocampal formation2.13
2.27
DpydHYHypothalamus0.52
1.01
DpydLSXLateral septal complex0.04
0
DpydMBMidbrain0.24
0.77
DpydMYMedulla2.54
4.09
DpydOLFOlfactory bulb1.97
2.95
DpydPPons0.25
0.41
DpydPALPallidum0.16
0.24
DpydRHPRetrohippocampal region0.93
0.81
DpydsAMYStriatum-like amygdalar nuclei0.24
0.38
DpydSTRStriatum0.13
0.23
DpydSTRdStriatum dorsal region0.06
0.19
DpydSTRvStriatum ventral region0.4
0.43
DpydTHThalamus1.74
2.69
Peptide Top

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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