AutismKB 2.0

Annotation Detail for DPYSL2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:DPYSL2 ( CRMP2,DHPRP2,DRP-2,DRP2 )
Gene Full Name: dihydropyrimidinase-like 2
Band: 8p21.2
Quick LinksEntrez ID:1808; OMIM: 602463; Uniprot ID:DPYL2_HUMAN; ENSEMBL ID: ENSG00000092964; HGNC ID: 3014
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst2 / 6231932
fetus26 / 56401246
neonate0 / 310970 
infant2 / 2362084
juvenile4 / 5555671
adult37 / 193912119
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma1 / 8282312
colorectal tumor1 / 1142468
esophageal tumor1 / 1729057
gastrointestinal tumor1 / 1193698
germ cell tumor7 / 26384526
glioma2 / 10688318
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia2 / 9584220
liver tumor3 / 9635931
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia7 / 9725071
normal102 / 336030730
ovarian tumor5 / 7668265
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone1 / 7165513
bone marrow1 / 4880120
brain74 / 110098967
cervix1 / 4817120
connective tissue4 / 14925526
ear1 / 1621261
embryonic tissue9 / 21572241
esophagus1 / 2020949
eye3 / 21105414
heart2 / 8962622
intestine2 / 2344728
kidney3 / 21177714
larynx0 / 241450 
liver3 / 20774314
lung3 / 3369748
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth0 / 670520 
muscle0 / 1077150 
nerve1 / 1576863
ovary5 / 10205148
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta2 / 2808257
prostate0 / 1893450 
salivary gland0 / 201550 
skin3 / 21057414
spleen0 / 539520 
stomach2 / 9661920
testis3 / 3304429
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus6 / 23287825
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 200762_at
Cell line Expression level Expression bar
721_B_lymphoblasts751.1
Adipocyte624.25
AdrenalCortex180.85
Adrenalgland282.3
Amygdala2203
Appendix250.75
AtrioventricularNode92.7
BDCA4+_DentriticCells929.25
Bonemarrow41.3
BronchialEpithelialCells73.75
CD105+_Endothelial37.8
CD14+_Monocytes879.15
CD19+_BCells(neg._sel.)64.65
CD33+_Myeloid851.95
CD34+303.45
CD4+_Tcells17.1
CD56+_NKCells315.8
CD71+_EarlyErythroid6.9
CD8+_Tcells22.65
CardiacMyocytes645.75
Caudatenucleus1533.65
Cerebellum2409.1
CerebellumPeduncles2465.15
CiliaryGanglion165.15
CingulateCortex1614.4
Colorectaladenocarcinoma174.6
DorsalRootGanglion347.35
FetalThyroid47.4
Fetalbrain3551.95
Fetalliver24.55
Fetallung317.45
GlobusPallidus1409.4
Heart82
Hypothalamus3030.75
Kidney148.2
Leukemia_chronicMyelogenousK-56222.85
Leukemia_promyelocytic-HL-6057.85
Leukemialymphoblastic(MOLT-4)198.25
Liver14.15
Lung631.5
Lymphnode101.7
Lymphoma_burkitts(Daudi)32.8
Lymphoma_burkitts(Raji)10.85
MedullaOblongata2101.75
OccipitalLobe3267.85
OlfactoryBulb792.2
Ovary69.25
Pancreas64.1
PancreaticIslet186.45
ParietalLobe3201.1
Pituitary266.95
Placenta404.25
Pons1300.5
PrefrontalCortex4675.35
Prostate79.1
Salivarygland60.9
SkeletalMuscle15.4
Skin56.75
SmoothMuscle1043.1
Spinalcord2544.9
SubthalamicNucleus1901.1
SuperiorCervicalGanglion146.1
TemporalLobe1433.7
Testis53
TestisGermCell80.1
TestisIntersitial26.85
TestisLeydigCell17.45
TestisSeminiferousTubule30.65
Thalamus1567.55
Thymus204.9
Thyroid100.15
Tongue24.6
Tonsil61.85
Trachea124.85
TrigeminalGanglion137.9
Uterus274.7
UterusCorpus12.3
WholeBlood212.3
Wholebrain2289.25
colon279.3
pineal_day1434.74
pineal_night1513.9
retina2145.225
small_intestine455.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P20337
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.92 ± 0.28
Basal Forebrain8.14 ± 0.19
Basal Part of Pons8.21 ± 0.35
Cerebellar Cortex8.06 ± 0.28
Cerebellar Nuclei8.16 ± 0.31
Claustrum8 ± 0.34
Epithalamus7.68 ± 0.52
Frontal Lobe8.02 ± 0.34
Globus Pallidus8.44 ± 0.28
Hypothalamus7.76 ± 0.33
Insula7.87 ± 0.25
Limbic Lobe8.03 ± 0.32
Mesencephalon7.94 ± 0.34
Myelencephalon8.01 ± 0.31
Occipital Lobe7.99 ± 0.32
Parietal Lobe7.98 ± 0.27
Pontine Tegmentum7.98 ± 0.39
Striatum7.75 ± 0.39
Subthalamus7.78 ± 0.41
Temporal Lobe7.97 ± 0.3
Thalamus7.99 ± 0.35
White Matter9.29 ± 0.12
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dpysl2CBCerebellum53.78
100
Dpysl2CTXCerebral cortex100
100
Dpysl2HIPHippocampal region100
100
Dpysl2HPFHippocampal formation100
100
Dpysl2HYHypothalamus100
100
Dpysl2LSXLateral septal complex100
100
Dpysl2MBMidbrain100
100
Dpysl2MYMedulla100
100
Dpysl2OLFOlfactory bulb100
100
Dpysl2PPons100
100
Dpysl2PALPallidum100
100
Dpysl2RHPRetrohippocampal region100
100
Dpysl2sAMYStriatum-like amygdalar nuclei100
100
Dpysl2STRStriatum95.89
100
Dpysl2STRdStriatum dorsal region89.19
96.35
Dpysl2STRvStriatum ventral region100
100
Dpysl2THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
DPYL2_HUMAN_0 0 0 0 AALAGGTTMIIDHVVPEPGTSLLAAFDQWR PRIDE
DPYL2_HUMAN_0 0 0 0 GIQEEMEALVK PRIDE
DPYL2_HUMAN_0 0 0 0 IAVGSDADLVIWDPDSVK PRIDE
DPYL2_HUMAN_0 0 0 0 ILDLGITGPEGHVLSRPEEVEAEAVNR PRIDE
DPYL2_HUMAN_0 0 0 0 IVLEDGTLHVTEGSGR PRIDE
DPYL2_HUMAN_0 0 0 0 MDENQFVAVTSTNAAK PRIDE
DPYL2_HUMAN_0 0 0 0 SCCDYSLHVDISEWHK PRIDE
DPYL2_HUMAN_0 0 0 0 SSAEVIAQAR PRIDE
DPYL2_HUMAN_146 11 146 156 GIQEEMEALVK PRIDE
DPYL2_HUMAN_171 18 171 188 DRFQLTDCQIYEVLSVIR PRIDE
DPYL2_HUMAN_189 22 189 210 DIGAIAQVHAENGDIIAEEQQR PRIDE
DPYL2_HUMAN_211 27 211 237 ILDLGITGPEGHVLSRPEEVEAEAVNR PRIDE
DPYL2_HUMAN_238 16 238 253 AITIANQTNCPLYITK PRIDE
DPYL2_HUMAN_258 10 258 267 SSAEVIAQAR PRIDE
DPYL2_HUMAN_270 23 270 292 GTVVYGEPITASLGTDGSHYWSK PRIDE
DPYL2_HUMAN_374 16 374 389 MDENQFVAVTSTNAAK PRIDE
DPYL2_HUMAN_390 7 390 396 VFNLYPR PRIDE
DPYL2_HUMAN_400 18 400 417 IAVGSDADLVIWDPDSVK PRIDE
DPYL2_HUMAN_423 17 423 439 THNSSLEYNIFEGMECR PRIDE
DPYL2_HUMAN_423 44 423 466 THNSSLEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGR PRIDE
DPYL2_HUMAN_43 13 43 55 QIGENLIVPGGVK PRIDE
DPYL2_HUMAN_440 11 440 450 GSPLVVISQGK PRIDE
DPYL2_HUMAN_451 16 451 466 IVLEDGTLHVTEGSGR PRIDE
DPYL2_HUMAN_496 15 496 510 GLYDGPVCEVSVTPK PRIDE
DPYL2_HUMAN_532 20 532 551 NLHQSGFSLSGAQIDDNIPR PRIDE
DPYL2_HUMAN_540 13 540 552 SLSGAQIDDNIPR PRIDE
DPYL2_HUMAN_63 12 63 74 MVIPGGIDVHTR PRIDE
DPYL2_HUMAN_64 12 64 75 MVIPGGIDVHTR PRIDE
DPYL2_HUMAN_75 19 75 93 FQMPDQGMTSADDFFQGTK PRIDE
DPYL2_HUMAN_76 19 76 94 FQMPDQGMTSADDFFQGTK PRIDE
DPYL2_HUMAN_94 30 94 123 AALAGGTTMIIDHVVPEPGTSLLAAFDQWR PRIDE
PAp00000452 16 239 254 AITIANQTNCPLYITK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved