AutismKB 2.0

Annotation Detail for JAG1


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Basic Information Top
Gene Symbol:JAG1 ( AGS,AHD,AWS,CD339,HJ1,JAGL1,MGC104644 )
Gene Full Name: jagged 1
Band: 20p12.2
Quick LinksEntrez ID:182; OMIM: 601920; Uniprot ID:JAG1_HUMAN; ENSEMBL ID: ENSG00000101384; HGNC ID: 6188
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Microarray in BioGPS Top
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  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209098_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts11.15
Adipocyte13.55
AdrenalCortex16.5
Adrenalgland11.3
Amygdala12.05
Appendix15.2
AtrioventricularNode15.55
BDCA4+_DentriticCells11.65
Bonemarrow13.85
BronchialEpithelialCells184.1
CD105+_Endothelial12.55
CD14+_Monocytes14.7
CD19+_BCells(neg._sel.)13.35
CD33+_Myeloid15.2
CD34+14.05
CD4+_Tcells14.2
CD56+_NKCells12.85
CD71+_EarlyErythroid12.5
CD8+_Tcells11.15
CardiacMyocytes56.6
Caudatenucleus10.9
Cerebellum10.55
CerebellumPeduncles15.4
CiliaryGanglion16.9
CingulateCortex13.95
Colorectaladenocarcinoma12.65
DorsalRootGanglion12.35
FetalThyroid13.75
Fetalbrain11.05
Fetalliver11.8
Fetallung11.6
GlobusPallidus10.1
Heart25.15
Hypothalamus13
Kidney13.4
Leukemia_chronicMyelogenousK-56210.35
Leukemia_promyelocytic-HL-6010.65
Leukemialymphoblastic(MOLT-4)8.65
Liver19.55
Lung16
Lymphnode10.1
Lymphoma_burkitts(Daudi)16.7
Lymphoma_burkitts(Raji)19.8
MedullaOblongata10.25
OccipitalLobe11.9
OlfactoryBulb9.85
Ovary14.95
Pancreas10.9
PancreaticIslet14.75
ParietalLobe14.85
Pituitary15.4
Placenta64.5
Pons13.6
PrefrontalCortex16.2
Prostate21.8
Salivarygland13.55
SkeletalMuscle18.55
Skin15.95
SmoothMuscle18.45
Spinalcord13.9
SubthalamicNucleus13.4
SuperiorCervicalGanglion20
TemporalLobe12.45
Testis11.6
TestisGermCell8.55
TestisIntersitial11.3
TestisLeydigCell14.45
TestisSeminiferousTubule11.35
Thalamus13.9
Thymus10.2
Thyroid17.3
Tongue17.25
Tonsil13.3
Trachea15.9
TrigeminalGanglion20.75
Uterus49.4
UterusCorpus13.25
WholeBlood12.35
Wholebrain10.05
colon62
pineal_day16.02
pineal_night15.44
retina107.375
small_intestine52.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P210763
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.16 ± 0.46
Basal Forebrain4.12 ± 0.28
Basal Part of Pons3.65 ± 0.48
Cerebellar Cortex3.51 ± 0.41
Cerebellar Nuclei4.36 ± 0.31
Claustrum3.28 ± 0.65
Epithalamus3.98 ± 0.48
Frontal Lobe4.05 ± 0.57
Globus Pallidus4.97 ± 0.46
Hypothalamus3.95 ± 0.53
Insula4.3 ± 0.37
Limbic Lobe4.16 ± 0.64
Mesencephalon4.18 ± 0.49
Myelencephalon4.05 ± 0.59
Occipital Lobe4.22 ± 0.58
Parietal Lobe4.09 ± 0.59
Pontine Tegmentum4.13 ± 0.63
Striatum4.67 ± 0.44
Subthalamus3.96 ± 0.21
Temporal Lobe4.05 ± 0.58
Thalamus4.06 ± 0.57
White Matter4.03 ± 1.2
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Jag1CBCerebellum2.44
3.37
Jag1CTXCerebral cortex2.57
2.46
Jag1HIPHippocampal region3.04
2.89
Jag1HPFHippocampal formation2.46
2.25
Jag1HYHypothalamus0.89
1.24
Jag1LSXLateral septal complex0.21
0.18
Jag1MBMidbrain1.06
1.28
Jag1MYMedulla1.55
1.7
Jag1OLFOlfactory bulb2.62
1.98
Jag1PPons0.89
1.17
Jag1PALPallidum0.39
0.49
Jag1RHPRetrohippocampal region1.56
1.4
Jag1sAMYStriatum-like amygdalar nuclei0.66
0.79
Jag1STRStriatum1.09
1.05
Jag1STRdStriatum dorsal region1.34
1.36
Jag1STRvStriatum ventral region0.75
0.54
Jag1THThalamus1.21
1.38
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00007615 18 408 425 TCQLDANECEAKPCVNAK Peptide Atlas

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018