AutismKB 2.0

Annotation Detail for DUSP3


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Basic Information Top
Gene Symbol:DUSP3 ( VHR )
Gene Full Name: dual specificity phosphatase 3
Band: 17q21.31
Quick LinksEntrez ID:1845; OMIM: 600183; Uniprot ID:DUS3_HUMAN; ENSEMBL ID: ENSG00000108861; HGNC ID: 3069
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst0 / 623190 
fetus49 / 56401286
neonate3 / 3109796
infant0 / 236200 
juvenile4 / 5555671
adult206 / 1939121106
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor10 / 94178106
cervical tumor1 / 3436629
chondrosarcoma9 / 82823108
colorectal tumor4 / 11424635
esophageal tumor1 / 1729057
gastrointestinal tumor8 / 11936967
germ cell tumor29 / 263845109
glioma13 / 106883121
head and neck tumor18 / 136302132
kidney tumor4 / 6895958
leukemia2 / 9584220
liver tumor9 / 9635993
lung tumor5 / 10312748
lymphoma1 / 7175513
non-neoplasia8 / 9725082
normal421 / 3360307125
ovarian tumor5 / 7668265
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer13 / 102680126
retinoblastoma2 / 4635643
skin tumor36 / 124949288
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites5 / 40015124
bladder1 / 2975733
blood3 / 12347824
bone8 / 71655111
bone marrow2 / 4880140
brain211 / 1100989191
cervix7 / 48171145
connective tissue11 / 14925573
ear2 / 16212123
embryonic tissue7 / 21572232
esophagus1 / 2020949
eye22 / 211054104
heart8 / 8962689
intestine12 / 23447251
kidney16 / 21177775
larynx1 / 2414541
liver19 / 20774391
lung64 / 336974189
lymph0 / 442700 
lymph node1 / 9161010
mammary gland15 / 15327197
mouth15 / 67052223
muscle5 / 10771546
nerve1 / 1576863
ovary8 / 10205178
pancreas20 / 21481293
parathyroid1 / 2053948
pharynx2 / 4132848
pituitary gland1 / 1658560
placenta21 / 28082574
prostate17 / 18934589
salivary gland3 / 20155148
skin55 / 210574261
spleen2 / 5395237
stomach4 / 9661941
testis39 / 330442118
thymus4 / 8113149
thyroid1 / 4747321
tonsil0 / 169990 
trachea5 / 5241395
umbilical cord2 / 13680146
uterus41 / 232878176
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201538_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.7
Adipocyte6.25
AdrenalCortex6.95
Adrenalgland5.35
Amygdala6.7
Appendix6.3
AtrioventricularNode5
BDCA4+_DentriticCells9.9
Bonemarrow6.25
BronchialEpithelialCells7
CD105+_Endothelial6.3
CD14+_Monocytes6.75
CD19+_BCells(neg._sel.)6.65
CD33+_Myeloid16.65
CD34+8
CD4+_Tcells6.9
CD56+_NKCells7.5
CD71+_EarlyErythroid5.8
CD8+_Tcells5.8
CardiacMyocytes8
Caudatenucleus5.65
Cerebellum5.1
CerebellumPeduncles7.3
CiliaryGanglion4.6
CingulateCortex6.4
Colorectaladenocarcinoma6.3
DorsalRootGanglion4.9
FetalThyroid6.1
Fetalbrain6.3
Fetalliver5.45
Fetallung5.3
GlobusPallidus4.6
Heart12.7
Hypothalamus6.9
Kidney5.4
Leukemia_chronicMyelogenousK-5625.7
Leukemia_promyelocytic-HL-605.5
Leukemialymphoblastic(MOLT-4)5.1
Liver9.15
Lung7.2
Lymphnode5.4
Lymphoma_burkitts(Daudi)7.95
Lymphoma_burkitts(Raji)8.8
MedullaOblongata5.7
OccipitalLobe5.75
OlfactoryBulb4.95
Ovary4.15
Pancreas5.05
PancreaticIslet6.7
ParietalLobe6.6
Pituitary7.35
Placenta11.3
Pons6
PrefrontalCortex7.9
Prostate7.4
Salivarygland5
SkeletalMuscle7.2
Skin5
SmoothMuscle7.2
Spinalcord6.7
SubthalamicNucleus5.8
SuperiorCervicalGanglion7.65
TemporalLobe8.35
Testis5.45
TestisGermCell5.3
TestisIntersitial5.35
TestisLeydigCell6.25
TestisSeminiferousTubule5.35
Thalamus6.35
Thymus4.95
Thyroid7.85
Tongue6.2
Tonsil6.05
Trachea5.3
TrigeminalGanglion6.25
Uterus5.2
UterusCorpus5.55
WholeBlood6.9
Wholebrain10
colon6.3
pineal_day7.92
pineal_night9.88
retina7.65
small_intestine6.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P400255
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.89 ± 0.55
Basal Forebrain5.7 ± 0.18
Basal Part of Pons5.82 ± 0.25
Cerebellar Cortex5.61 ± 0.29
Cerebellar Nuclei5.83 ± 0.18
Claustrum6.28 ± 0.31
Epithalamus5.28 ± 0.25
Frontal Lobe5.91 ± 0.33
Globus Pallidus5.15 ± 0.53
Hypothalamus5.57 ± 0.27
Insula5.75 ± 0.19
Limbic Lobe5.84 ± 0.39
Mesencephalon5.79 ± 0.59
Myelencephalon5.75 ± 0.42
Occipital Lobe5.48 ± 0.42
Parietal Lobe5.77 ± 0.36
Pontine Tegmentum5.73 ± 0.35
Striatum5.43 ± 0.54
Subthalamus5.77 ± 0.25
Temporal Lobe5.87 ± 0.32
Thalamus5.77 ± 0.3
White Matter4.91 ± 0.27
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dusp3CBCerebellum9.02
10.86
Dusp3CTXCerebral cortex50
50
Dusp3HIPHippocampal region23.14
37.54
Dusp3HPFHippocampal formation26.75
36.51
Dusp3HYHypothalamus1.96
1.75
Dusp3LSXLateral septal complex2.17
1.78
Dusp3MBMidbrain4.84
5.33
Dusp3MYMedulla6.57
9.08
Dusp3OLFOlfactory bulb26.01
30.17
Dusp3PPons7.25
9.41
Dusp3PALPallidum4.5
5.51
Dusp3RHPRetrohippocampal region31.85
35.44
Dusp3sAMYStriatum-like amygdalar nuclei3.05
3.35
Dusp3STRStriatum16.56
13.55
Dusp3STRdStriatum dorsal region21.62
17.78
Dusp3STRvStriatum ventral region13.83
10.73
Dusp3THThalamus9.22
8.76
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
DUS3_HUMAN_0 0 0 0 IYVGNASVAQDIPK PRIDE
DUS3_HUMAN_0 0 0 0 LGITHVLNAAEGR PRIDE
DUS3_HUMAN_104 12 104 115 AADFIDQALAQK PRIDE
DUS3_HUMAN_130 12 130 141 SPTLVIAYLMMR PRIDE
DUS3_HUMAN_158 18 158 175 EIGPNDGFLAQLCQLNDR PRIDE
DUS3_HUMAN_36 14 36 49 IYVGNASVAQDIPK PRIDE
DUS3_HUMAN_36 17 36 52 IYVGNASVAQDIPKLQK PRIDE
DUS3_HUMAN_53 13 53 65 LGITHVLNAAEGR PRIDE
DUS3_HUMAN_66 13 66 78 SFMHVNTNANFYK PRIDE
DUS3_HUMAN_79 10 79 88 DSGITYLGIK PRIDE
DUS3_HUMAN_89 15 89 103 ANDTQEFNLSAYFER PRIDE
PAp00002072 18 159 176 EIGPNDGFLAQLCQLNDR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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