AutismKB 2.0

Annotation Detail for DUSP4


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Basic Information Top
Gene Symbol:DUSP4 ( HVH2,MKP-2,MKP2,TYP )
Gene Full Name: dual specificity phosphatase 4
Band: 8p12
Quick LinksEntrez ID:1846; OMIM: 602747; Uniprot ID:DUS4_HUMAN; ENSEMBL ID: ENSG00000120875; HGNC ID: 3070
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst4 / 6231964
fetus32 / 56401256
neonate1 / 3109732
infant0 / 236200 
juvenile1 / 5555617
adult84 / 193912143
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor13 / 94178138
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor3 / 11424626
esophageal tumor1 / 1729057
gastrointestinal tumor15 / 119369125
germ cell tumor28 / 263845106
glioma5 / 10688346
head and neck tumor4 / 13630229
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor13 / 103127126
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal116 / 336030734
ovarian tumor7 / 7668291
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS6 / 12568047
prostate cancer2 / 10268019
retinoblastoma2 / 4635643
skin tumor41 / 124949328
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites11 / 40015274
bladder2 / 2975767
blood14 / 123478113
bone1 / 7165513
bone marrow0 / 488010 
brain45 / 110098940
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue9 / 21572241
esophagus1 / 2020949
eye5 / 21105423
heart1 / 8962611
intestine3 / 23447212
kidney4 / 21177718
larynx0 / 241450 
liver2 / 2077439
lung22 / 33697465
lymph0 / 442700 
lymph node0 / 916100 
mammary gland21 / 153271137
mouth0 / 670520 
muscle0 / 1077150 
nerve1 / 1576863
ovary8 / 10205178
pancreas7 / 21481232
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta15 / 28082553
prostate9 / 18934547
salivary gland0 / 201550 
skin45 / 210574213
spleen0 / 539520 
stomach4 / 9661941
testis8 / 33044224
thymus1 / 8113112
thyroid4 / 4747384
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus4 / 23287817
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204014_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.3
Adipocyte19.25
AdrenalCortex8.45
Adrenalgland5.9
Amygdala6.65
Appendix7.8
AtrioventricularNode6.95
BDCA4+_DentriticCells6.35
Bonemarrow7.35
BronchialEpithelialCells28.45
CD105+_Endothelial6.55
CD14+_Monocytes7.05
CD19+_BCells(neg._sel.)6.95
CD33+_Myeloid8.05
CD34+7.95
CD4+_Tcells7.05
CD56+_NKCells7.3
CD71+_EarlyErythroid6.25
CD8+_Tcells5.85
CardiacMyocytes11.1
Caudatenucleus5.9
Cerebellum5.55
CerebellumPeduncles8.15
CiliaryGanglion6.8
CingulateCortex7.05
Colorectaladenocarcinoma6.7
DorsalRootGanglion6.3
FetalThyroid6.9
Fetalbrain6.25
Fetalliver5.7
Fetallung5.05
GlobusPallidus5.25
Heart10.45
Hypothalamus6.7
Kidney5.75
Leukemia_chronicMyelogenousK-5625.85
Leukemia_promyelocytic-HL-605.75
Leukemialymphoblastic(MOLT-4)4.9
Liver9.85
Lung8.1
Lymphnode5.25
Lymphoma_burkitts(Daudi)8.6
Lymphoma_burkitts(Raji)10.05
MedullaOblongata5.85
OccipitalLobe5.9
OlfactoryBulb5.15
Ovary5.1
Pancreas21.85
PancreaticIslet19.2
ParietalLobe7.35
Pituitary7.65
Placenta78.45
Pons6.55
PrefrontalCortex7.75
Prostate7.95
Salivarygland5.8
SkeletalMuscle10.35
Skin7.4
SmoothMuscle7.4
Spinalcord6.95
SubthalamicNucleus6.4
SuperiorCervicalGanglion12.05
TemporalLobe6.3
Testis5.55
TestisGermCell5.15
TestisIntersitial5.95
TestisLeydigCell6.75
TestisSeminiferousTubule5.65
Thalamus6.85
Thymus5.3
Thyroid7.9
Tongue7.8
Tonsil6.65
Trachea5.7
TrigeminalGanglion9.55
Uterus5.15
UterusCorpus6.8
WholeBlood7.05
Wholebrain5.85
colon6.85
pineal_day28.72
pineal_night94.4
retina60.875
small_intestine6.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7909_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.1 ± 0.87
Basal Forebrain2.5 ± 0.42
Basal Part of Pons2.23 ± 0.36
Cerebellar Cortex3.17 ± 0.81
Cerebellar Nuclei2.86 ± 0.74
Claustrum3.5 ± 1.13
Epithalamus2.17 ± 0.96
Frontal Lobe2.66 ± 0.85
Globus Pallidus2.72 ± 0.53
Hypothalamus2.49 ± 0.53
Insula2.84 ± 1.12
Limbic Lobe2.93 ± 0.78
Mesencephalon2.92 ± 0.82
Myelencephalon2.76 ± 0.78
Occipital Lobe2.66 ± 0.67
Parietal Lobe2.79 ± 0.77
Pontine Tegmentum2.81 ± 0.83
Striatum2.47 ± 0.68
Subthalamus2.83 ± 0.84
Temporal Lobe2.69 ± 0.77
Thalamus2.58 ± 0.69
White Matter2.51 ± 0.38
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dusp4CBCerebellum8.64
9.84
Dusp4CTXCerebral cortex12.58
9.57
Dusp4HIPHippocampal region22.36
29.07
Dusp4HPFHippocampal formation22.21
24.33
Dusp4HYHypothalamus2.1
1.72
Dusp4LSXLateral septal complex12.78
11.08
Dusp4MBMidbrain2.99
3.07
Dusp4MYMedulla8
9.44
Dusp4OLFOlfactory bulb20.1
17.27
Dusp4PPons5.69
6.51
Dusp4PALPallidum3.42
3.37
Dusp4RHPRetrohippocampal region22.82
19.23
Dusp4sAMYStriatum-like amygdalar nuclei4.24
3.26
Dusp4STRStriatum2.88
2.4
Dusp4STRdStriatum dorsal region1.3
1.07
Dusp4STRvStriatum ventral region3.6
2.87
Dusp4THThalamus5.63
4.58
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
DUS4_HUMAN_1 8 1 8 MVTMEELR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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