AutismKB 2.0

Annotation Detail for DUSP5


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Basic Information Top
Gene Symbol:DUSP5 ( DUSP,HVH3 )
Gene Full Name: dual specificity phosphatase 5
Band: 10q25.2
Quick LinksEntrez ID:1847; OMIM: 603069; Uniprot ID:DUS5_HUMAN; ENSEMBL ID: ENSG00000138166; HGNC ID: 3071
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst1 / 6231916
fetus20 / 56401235
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult93 / 193912147
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor0 / 343660 
chondrosarcoma9 / 82823108
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor11 / 26384541
glioma4 / 10688337
head and neck tumor4 / 13630229
kidney tumor1 / 6895914
leukemia1 / 9584210
liver tumor4 / 9635941
lung tumor5 / 10312748
lymphoma3 / 7175541
non-neoplasia3 / 9725030
normal103 / 336030730
ovarian tumor6 / 7668278
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer7 / 10268068
retinoblastoma0 / 463560 
skin tumor20 / 124949160
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites0 / 400150 
bladder1 / 2975733
blood7 / 12347856
bone9 / 71655125
bone marrow2 / 4880140
brain14 / 110098912
cervix5 / 48171103
connective tissue5 / 14925533
ear2 / 16212123
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye9 / 21105442
heart7 / 8962678
intestine7 / 23447229
kidney5 / 21177723
larynx0 / 241450 
liver5 / 20774324
lung15 / 33697444
lymph3 / 4427067
lymph node0 / 916100 
mammary gland8 / 15327152
mouth0 / 670520 
muscle1 / 1077159
nerve1 / 1576863
ovary7 / 10205168
pancreas8 / 21481237
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta28 / 28082599
prostate9 / 18934547
salivary gland0 / 201550 
skin25 / 210574118
spleen2 / 5395237
stomach6 / 9661962
testis11 / 33044233
thymus0 / 811310 
thyroid4 / 4747384
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209457_at
Cell line Expression level Expression bar
721_B_lymphoblasts148.65
Adipocyte5.15
AdrenalCortex156.75
Adrenalgland32.85
Amygdala5.7
Appendix5.5
AtrioventricularNode3.9
BDCA4+_DentriticCells1199.4
Bonemarrow5.05
BronchialEpithelialCells165.2
CD105+_Endothelial5.7
CD14+_Monocytes14
CD19+_BCells(neg._sel.)46.05
CD33+_Myeloid13.6
CD34+6.05
CD4+_Tcells6.95
CD56+_NKCells65.1
CD71+_EarlyErythroid4.35
CD8+_Tcells5.1
CardiacMyocytes6.35
Caudatenucleus4.25
Cerebellum151.5
CerebellumPeduncles33.95
CiliaryGanglion3.65
CingulateCortex5.1
Colorectaladenocarcinoma100.7
DorsalRootGanglion4
FetalThyroid5
Fetalbrain5.15
Fetalliver4.5
Fetallung6.75
GlobusPallidus3.7
Heart9.1
Hypothalamus5.35
Kidney4.15
Leukemia_chronicMyelogenousK-5624.5
Leukemia_promyelocytic-HL-6026.7
Leukemialymphoblastic(MOLT-4)3.9
Liver6.35
Lung6.5
Lymphnode12.9
Lymphoma_burkitts(Daudi)6.8
Lymphoma_burkitts(Raji)332.45
MedullaOblongata4.35
OccipitalLobe4.4
OlfactoryBulb16
Ovary3.2
Pancreas4.85
PancreaticIslet43.6
ParietalLobe5.3
Pituitary6
Placenta404.65
Pons4.7
PrefrontalCortex6.4
Prostate5.65
Salivarygland4.3
SkeletalMuscle5.75
Skin3.95
SmoothMuscle5.65
Spinalcord5.25
SubthalamicNucleus4.6
SuperiorCervicalGanglion5.95
TemporalLobe4.4
Testis55.45
TestisGermCell25.9
TestisIntersitial8.6
TestisLeydigCell11.45
TestisSeminiferousTubule24.2
Thalamus5.25
Thymus7.35
Thyroid6.6
Tongue7.4
Tonsil6.5
Trachea80.35
TrigeminalGanglion5.1
Uterus4.25
UterusCorpus4.85
WholeBlood10.2
Wholebrain4.15
colon4.95
pineal_day97.3
pineal_night152.38
retina52.25
small_intestine38.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_11669_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.35 ± 0.96
Basal Forebrain3.79 ± 0.51
Basal Part of Pons3.71 ± 0.65
Cerebellar Cortex5.15 ± 0.4
Cerebellar Nuclei3.32 ± 0.52
Claustrum4.88 ± 1.2
Epithalamus3.69 ± 0.53
Frontal Lobe3.97 ± 0.82
Globus Pallidus3.76 ± 0.73
Hypothalamus3.34 ± 0.94
Insula3.87 ± 0.46
Limbic Lobe4.66 ± 0.91
Mesencephalon4.13 ± 0.8
Myelencephalon4.22 ± 0.83
Occipital Lobe4.81 ± 0.86
Parietal Lobe4.36 ± 0.77
Pontine Tegmentum4.29 ± 0.96
Striatum4.08 ± 0.91
Subthalamus4.42 ± 0.49
Temporal Lobe3.99 ± 0.91
Thalamus4.59 ± 0.56
White Matter3.14 ± 0.55
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dusp5CBCerebellum100
100
Dusp5CTXCerebral cortex40.55
32.23
Dusp5HIPHippocampal region37.36
67.52
Dusp5HPFHippocampal formation38.91
54.93
Dusp5HYHypothalamus1.04
0.83
Dusp5LSXLateral septal complex16.33
13.65
Dusp5MBMidbrain2.75
2.87
Dusp5MYMedulla13.7
18.07
Dusp5OLFOlfactory bulb36.38
42.92
Dusp5PPons5.8
6.18
Dusp5PALPallidum2.6
2.37
Dusp5RHPRetrohippocampal region42.02
42.44
Dusp5sAMYStriatum-like amygdalar nuclei4.8
3.67
Dusp5STRStriatum10.84
8.13
Dusp5STRdStriatum dorsal region10.18
7.66
Dusp5STRvStriatum ventral region13.68
9.22
Dusp5THThalamus11.72
9.81
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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