AutismKB 2.0

Annotation Detail for DUSP6


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Basic Information Top
Gene Symbol:DUSP6 ( MKP3,PYST1 )
Gene Full Name: dual specificity phosphatase 6
Band: 12q21.33
Quick LinksEntrez ID:1848; OMIM: 602748; Uniprot ID:DUS6_HUMAN; ENSEMBL ID: ENSG00000139318; HGNC ID: 3072
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst1 / 6231916
fetus28 / 56401249
neonate2 / 3109764
infant0 / 236200 
juvenile1 / 5555617
adult108 / 193912155
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma7 / 17475400
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor7 / 11424661
esophageal tumor0 / 172900 
gastrointestinal tumor14 / 119369117
germ cell tumor11 / 26384541
glioma5 / 10688346
head and neck tumor9 / 13630266
kidney tumor2 / 6895929
leukemia6 / 9584262
liver tumor7 / 9635972
lung tumor5 / 10312748
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal149 / 336030744
ovarian tumor2 / 7668226
pancreatic tumor11 / 104616105
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer4 / 10268038
retinoblastoma0 / 463560 
skin tumor17 / 124949136
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland2 / 3319760
ascites5 / 40015124
bladder7 / 29757235
blood11 / 12347889
bone5 / 7165569
bone marrow5 / 48801102
brain22 / 110098919
cervix0 / 481710 
connective tissue2 / 14925513
ear2 / 16212123
embryonic tissue13 / 21572260
esophagus0 / 202090 
eye3 / 21105414
heart5 / 8962655
intestine14 / 23447259
kidney6 / 21177728
larynx1 / 2414541
liver11 / 20774352
lung32 / 33697494
lymph0 / 442700 
lymph node3 / 9161032
mammary gland9 / 15327158
mouth0 / 670520 
muscle2 / 10771518
nerve1 / 1576863
ovary5 / 10205148
pancreas13 / 21481260
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta20 / 28082571
prostate8 / 18934542
salivary gland0 / 201550 
skin17 / 21057480
spleen0 / 539520 
stomach5 / 9661951
testis11 / 33044233
thymus0 / 811310 
thyroid10 / 47473210
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord2 / 13680146
uterus8 / 23287834
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208892_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts10.35
Adipocyte39.8
AdrenalCortex13.25
Adrenalgland14.4
Amygdala66.25
Appendix20.35
AtrioventricularNode12.25
BDCA4+_DentriticCells242.2
Bonemarrow17.2
BronchialEpithelialCells990.75
CD105+_Endothelial320.8
CD14+_Monocytes1467.25
CD19+_BCells(neg._sel.)17.25
CD33+_Myeloid2785.1
CD34+410.35
CD4+_Tcells11.6
CD56+_NKCells417.75
CD71+_EarlyErythroid14.75
CD8+_Tcells9.3
CardiacMyocytes19.7
Caudatenucleus13.3
Cerebellum9.5
CerebellumPeduncles13.9
CiliaryGanglion32.5
CingulateCortex79.9
Colorectaladenocarcinoma2079.25
DorsalRootGanglion24.05
FetalThyroid24.35
Fetalbrain14.95
Fetalliver33.25
Fetallung221.95
GlobusPallidus24.75
Heart17.3
Hypothalamus16.7
Kidney26.45
Leukemia_chronicMyelogenousK-56210.85
Leukemia_promyelocytic-HL-609.85
Leukemialymphoblastic(MOLT-4)10.6
Liver18.15
Lung438.5
Lymphnode26.4
Lymphoma_burkitts(Daudi)18.35
Lymphoma_burkitts(Raji)15.5
MedullaOblongata31
OccipitalLobe49.65
OlfactoryBulb159.8
Ovary13
Pancreas208.8
PancreaticIslet16.15
ParietalLobe18.2
Pituitary22.7
Placenta287.9
Pons16.75
PrefrontalCortex24.3
Prostate26.85
Salivarygland131.15
SkeletalMuscle14.65
Skin11.3
SmoothMuscle109.5
Spinalcord13.05
SubthalamicNucleus17.95
SuperiorCervicalGanglion16.25
TemporalLobe32.25
Testis10.7
TestisGermCell10.1
TestisIntersitial11.55
TestisLeydigCell13.7
TestisSeminiferousTubule12.55
Thalamus13.5
Thymus50.9
Thyroid142.65
Tongue13.4
Tonsil46.5
Trachea181
TrigeminalGanglion13.5
Uterus67.45
UterusCorpus12.5
WholeBlood989.9
Wholebrain70.4
colon83.7
pineal_day36.86
pineal_night25.74
retina518.525
small_intestine103.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14314_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.23 ± 0.41
Basal Forebrain7.86 ± 0.63
Basal Part of Pons8.28 ± 0.39
Cerebellar Cortex7.54 ± 0.37
Cerebellar Nuclei7.88 ± 0.34
Claustrum8.48 ± 0.33
Epithalamus7.39 ± 0.54
Frontal Lobe8.6 ± 0.6
Globus Pallidus7.18 ± 1.07
Hypothalamus7.75 ± 0.36
Insula8.36 ± 0.46
Limbic Lobe8.6 ± 0.89
Mesencephalon7.83 ± 0.43
Myelencephalon8.34 ± 0.63
Occipital Lobe8.45 ± 0.64
Parietal Lobe8.35 ± 0.57
Pontine Tegmentum8.35 ± 0.6
Striatum8.53 ± 0.65
Subthalamus7.81 ± 0.31
Temporal Lobe8.27 ± 0.73
Thalamus8.51 ± 0.45
White Matter6.81 ± 0.82
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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