AutismKB 2.0

Annotation Detail for DUSP8


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Basic Information Top
Gene Symbol:DUSP8 ( C11orf81,FLJ42476,FLJ42958,HB5,HVH-5,HVH8 )
Gene Full Name: dual specificity phosphatase 8
Band: 11p15.5
Quick LinksEntrez ID:1850; OMIM: 602038; Uniprot ID:CK081_HUMAN; ENSEMBL ID: ENSG00000184545; HGNC ID: 3074
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus2 / 5640123
neonate0 / 310970 
infant1 / 2362042
juvenile0 / 555560 
adult22 / 193912111
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor0 / 2638450 
glioma5 / 10688346
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor1 / 9635910
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal42 / 336030712
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS8 / 12568063
prostate cancer1 / 1026809
retinoblastoma1 / 4635621
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone0 / 716550 
bone marrow0 / 488010 
brain22 / 110098919
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye7 / 21105433
heart0 / 896260 
intestine4 / 23447217
kidney1 / 2117774
larynx0 / 241450 
liver2 / 2077439
lung5 / 33697414
lymph0 / 442700 
lymph node0 / 916100 
mammary gland2 / 15327113
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas12 / 21481255
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate1 / 1893455
salivary gland0 / 201550 
skin5 / 21057423
spleen0 / 539520 
stomach1 / 9661910
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206374_at
Cell line Expression level Expression bar
721_B_lymphoblasts11.75
Adipocyte9.7
AdrenalCortex10.65
Adrenalgland8.55
Amygdala39.75
Appendix10.05
AtrioventricularNode7.45
BDCA4+_DentriticCells9.3
Bonemarrow9.65
BronchialEpithelialCells9
CD105+_Endothelial9.55
CD14+_Monocytes10.55
CD19+_BCells(neg._sel.)10.05
CD33+_Myeloid12.25
CD34+12
CD4+_Tcells11
CD56+_NKCells11.3
CD71+_EarlyErythroid9.25
CD8+_Tcells11.55
CardiacMyocytes12.5
Caudatenucleus29.15
Cerebellum17.85
CerebellumPeduncles25.6
CiliaryGanglion6.95
CingulateCortex27.8
Colorectaladenocarcinoma9.85
DorsalRootGanglion7.5
FetalThyroid9.55
Fetalbrain35.55
Fetalliver8.45
Fetallung7.85
GlobusPallidus26.35
Heart23.9
Hypothalamus11.1
Kidney8.2
Leukemia_chronicMyelogenousK-5628.95
Leukemia_promyelocytic-HL-608.25
Leukemialymphoblastic(MOLT-4)7.85
Liver13.35
Lung12.1
Lymphnode8.35
Lymphoma_burkitts(Daudi)12.55
Lymphoma_burkitts(Raji)13.9
MedullaOblongata17.8
OccipitalLobe30.95
OlfactoryBulb7.75
Ovary6.5
Pancreas8.2
PancreaticIslet10.5
ParietalLobe17.15
Pituitary13.95
Placenta9.95
Pons28.6
PrefrontalCortex61.45
Prostate15.6
Salivarygland7.85
SkeletalMuscle12.6
Skin7.75
SmoothMuscle11.1
Spinalcord10.55
SubthalamicNucleus18.75
SuperiorCervicalGanglion11.05
TemporalLobe41.4
Testis8.45
TestisGermCell8.15
TestisIntersitial8.35
TestisLeydigCell9.3
TestisSeminiferousTubule8.45
Thalamus12
Thymus7.65
Thyroid12.35
Tongue9.6
Tonsil9.7
Trachea8.25
TrigeminalGanglion10.1
Uterus12.35
UterusCorpus8.8
WholeBlood9.9
Wholebrain35.1
colon9.9
pineal_day151.22
pineal_night194.74
retina16.45
small_intestine9.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P390528
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala10.51 ± 0.44
Basal Forebrain10.12 ± 0.22
Basal Part of Pons10.07 ± 0.36
Cerebellar Cortex10.18 ± 0.26
Cerebellar Nuclei9.55 ± 0.66
Claustrum10.18 ± 0.32
Epithalamus9.08 ± 0.37
Frontal Lobe9.97 ± 0.4
Globus Pallidus8.54 ± 0.44
Hypothalamus9.73 ± 0.57
Insula10.28 ± 0.29
Limbic Lobe10.45 ± 0.47
Mesencephalon9.96 ± 0.51
Myelencephalon10.12 ± 0.51
Occipital Lobe10.78 ± 0.48
Parietal Lobe10.21 ± 0.3
Pontine Tegmentum9.98 ± 0.35
Striatum10.72 ± 0.25
Subthalamus9.89 ± 0.22
Temporal Lobe10.28 ± 0.31
Thalamus9.87 ± 0.31
White Matter8.51 ± 0.45
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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