AutismKB 2.0

Annotation Detail for DVL3


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Basic Information Top
Gene Symbol:DVL3 ( KIAA0208 )
Gene Full Name: dishevelled, dsh homolog 3 (Drosophila)
Band: 3q27.1
Quick LinksEntrez ID:1857; OMIM: 601368; Uniprot ID:DVL3_HUMAN; ENSEMBL ID: ENSG00000161202; HGNC ID: 3087
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst4 / 6231964
fetus29 / 56401251
neonate0 / 310970 
infant1 / 2362042
juvenile1 / 5555617
adult207 / 1939121106
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor11 / 94178116
cervical tumor5 / 34366145
chondrosarcoma10 / 82823120
colorectal tumor28 / 114246245
esophageal tumor0 / 172900 
gastrointestinal tumor7 / 11936958
germ cell tumor14 / 26384553
glioma11 / 106883102
head and neck tumor16 / 136302117
kidney tumor4 / 6895958
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor10 / 10312796
lymphoma2 / 7175527
non-neoplasia4 / 9725041
normal196 / 336030758
ovarian tumor10 / 76682130
pancreatic tumor12 / 104616114
primitive neuroectodermal tumor of the CNS6 / 12568047
prostate cancer6 / 10268058
retinoblastoma0 / 463560 
skin tumor21 / 124949168
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor9 / 9025799
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites2 / 4001549
bladder1 / 2975733
blood3 / 12347824
bone8 / 71655111
bone marrow1 / 4880120
brain48 / 110098943
cervix5 / 48171103
connective tissue7 / 14925546
ear0 / 162120 
embryonic tissue16 / 21572274
esophagus0 / 202090 
eye21 / 21105499
heart3 / 8962633
intestine42 / 234472179
kidney7 / 21177733
larynx6 / 24145248
liver0 / 2077430 
lung23 / 33697468
lymph0 / 442700 
lymph node5 / 9161054
mammary gland17 / 153271110
mouth4 / 6705259
muscle0 / 1077150 
nerve1 / 1576863
ovary11 / 102051107
pancreas18 / 21481283
parathyroid0 / 205390 
pharynx3 / 4132872
pituitary gland0 / 165850 
placenta29 / 280825103
prostate10 / 18934552
salivary gland0 / 201550 
skin25 / 210574118
spleen0 / 539520 
stomach7 / 9661972
testis15 / 33044245
thymus0 / 811310 
thyroid27 / 47473568
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus17 / 23287872
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201908_at
Cell line Expression level Expression bar
721_B_lymphoblasts28
Adipocyte25.1
AdrenalCortex17.6
Adrenalgland26.85
Amygdala18.45
Appendix19.25
AtrioventricularNode12.65
BDCA4+_DentriticCells19.1
Bonemarrow17.2
BronchialEpithelialCells16.05
CD105+_Endothelial15.9
CD14+_Monocytes18.25
CD19+_BCells(neg._sel.)17.3
CD33+_Myeloid31.95
CD34+49
CD4+_Tcells18.4
CD56+_NKCells18.55
CD71+_EarlyErythroid15.9
CD8+_Tcells16.95
CardiacMyocytes21.7
Caudatenucleus16.15
Cerebellum16.35
CerebellumPeduncles18.6
CiliaryGanglion11.85
CingulateCortex17.65
Colorectaladenocarcinoma30.55
DorsalRootGanglion13
FetalThyroid16.25
Fetalbrain20.25
Fetalliver23.95
Fetallung38.3
GlobusPallidus12.15
Heart21.75
Hypothalamus19.05
Kidney22.95
Leukemia_chronicMyelogenousK-56217.25
Leukemia_promyelocytic-HL-6015.3
Leukemialymphoblastic(MOLT-4)21.9
Liver16.3
Lung19.1
Lymphnode18.8
Lymphoma_burkitts(Daudi)22.3
Lymphoma_burkitts(Raji)16
MedullaOblongata15.55
OccipitalLobe15.5
OlfactoryBulb28.15
Ovary14.65
Pancreas13.5
PancreaticIslet17.8
ParietalLobe16.25
Pituitary36.6
Placenta275.9
Pons16.35
PrefrontalCortex23.45
Prostate20.2
Salivarygland13.3
SkeletalMuscle19
Skin12.9
SmoothMuscle19.6
Spinalcord18.5
SubthalamicNucleus15.1
SuperiorCervicalGanglion19.75
TemporalLobe15.3
Testis14.95
TestisGermCell18.6
TestisIntersitial14.65
TestisLeydigCell16.95
TestisSeminiferousTubule15.6
Thalamus14.5
Thymus18.45
Thyroid27.65
Tongue15.85
Tonsil22.1
Trachea22.25
TrigeminalGanglion24.2
Uterus29.8
UterusCorpus21.45
WholeBlood19.6
Wholebrain13.65
colon19.3
pineal_day51.18
pineal_night53.88
retina123.775
small_intestine33.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P283000
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.21 ± 0.67
Basal Forebrain3.65 ± 0.42
Basal Part of Pons4.21 ± 0.54
Cerebellar Cortex4.26 ± 0.58
Cerebellar Nuclei3.84 ± 0.52
Claustrum3.8 ± 0.79
Epithalamus3.97 ± 0.69
Frontal Lobe4.14 ± 0.59
Globus Pallidus3.4 ± 0.68
Hypothalamus4.03 ± 0.94
Insula4.05 ± 0.61
Limbic Lobe3.86 ± 0.64
Mesencephalon4.04 ± 0.6
Myelencephalon3.98 ± 0.58
Occipital Lobe3.6 ± 0.51
Parietal Lobe3.94 ± 0.56
Pontine Tegmentum3.91 ± 0.69
Striatum3.47 ± 0.52
Subthalamus3.99 ± 1.01
Temporal Lobe4.22 ± 0.56
Thalamus4.03 ± 0.62
White Matter4.18 ± 0.27
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dvl3CBCerebellum41.89
70.53
Dvl3CTXCerebral cortex48.32
37.7
Dvl3HIPHippocampal region34.67
53.12
Dvl3HPFHippocampal formation31.52
38.82
Dvl3HYHypothalamus13.83
11.04
Dvl3LSXLateral septal complex7.9
10.75
Dvl3MBMidbrain26.76
25.77
Dvl3MYMedulla36.66
41.32
Dvl3OLFOlfactory bulb39.84
37.4
Dvl3PPons27.71
29.21
Dvl3PALPallidum15.56
15.05
Dvl3RHPRetrohippocampal region27.33
22.77
Dvl3sAMYStriatum-like amygdalar nuclei13.54
9.41
Dvl3STRStriatum7.79
6.93
Dvl3STRdStriatum dorsal region5.93
5.62
Dvl3STRvStriatum ventral region10.69
8.2
Dvl3THThalamus27.73
25.4
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
DVL3_HUMAN_293 25 293 317 IEPGDMLLQVNEINFENMSNDDAVR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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