Annotation Detail for DYRK1A
Basic Information Top
| Gene Symbol: | DYRK1A ( DYRK,DYRK1,HP86,MNB,MNBH ) |
|---|---|
| Gene Full Name: | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A |
| Band: | 21q22.13 |
| Quick Links | Entrez ID:1859; OMIM: 600855; Uniprot ID:DYR1A_HUMAN; ENSEMBL ID: ENSG00000157540; HGNC ID: 3091 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.368240
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 5 / 70761 | 70 |  |
| blastocyst | 0 / 62319 | 0 | |
| fetus | 38 / 564012 | 67 | |
| neonate | 0 / 31097 | 0 | |
| infant | 3 / 23620 | 127 | |
| juvenile | 4 / 55556 | 71 | |
| adult | 99 / 1939121 | 51 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 6 / 94178 | 63 | |
| cervical tumor | 0 / 34366 | 0 | |
| chondrosarcoma | 3 / 82823 | 36 |  |
| colorectal tumor | 3 / 114246 | 26 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 4 / 119369 | 33 | |
| germ cell tumor | 13 / 263845 | 49 | |
| glioma | 6 / 106883 | 56 | |
| head and neck tumor | 23 / 136302 | 168 | |
| kidney tumor | 4 / 68959 | 58 | |
| leukemia | 7 / 95842 | 73 | |
| liver tumor | 1 / 96359 | 10 |  |
| lung tumor | 3 / 103127 | 29 | |
| lymphoma | 2 / 71755 | 27 | |
| non-neoplasia | 6 / 97250 | 61 | |
| normal | 163 / 3360307 | 48 | |
| ovarian tumor | 2 / 76682 | 26 | |
| pancreatic tumor | 0 / 104616 | 0 | |
| primitive neuroectodermal tumor of the CNS | 7 / 125680 | 55 | |
| prostate cancer | 3 / 102680 | 29 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 5 / 124949 | 40 | |
| soft tissue/muscle tissue tumor | 3 / 125191 | 23 | |
| uterine tumor | 4 / 90257 | 44 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 2 / 29757 | 67 | |
| blood | 11 / 123478 | 89 | |
| bone | 2 / 71655 | 27 | |
| bone marrow | 1 / 48801 | 20 | |
| brain | 56 / 1100989 | 50 | |
| cervix | 0 / 48171 | 0 | |
| connective tissue | 4 / 149255 | 26 | |
| ear | 8 / 16212 | 493 |  |
| embryonic tissue | 12 / 215722 | 55 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 8 / 211054 | 37 | |
| heart | 6 / 89626 | 66 | |
| intestine | 6 / 234472 | 25 | |
| kidney | 14 / 211777 | 66 | |
| larynx | 0 / 24145 | 0 | |
| liver | 2 / 207743 | 9 | |
| lung | 18 / 336974 | 53 | |
| lymph | 2 / 44270 | 45 | |
| lymph node | 4 / 91610 | 43 | |
| mammary gland | 7 / 153271 | 45 | |
| mouth | 21 / 67052 | 313 | |
| muscle | 3 / 107715 | 27 | |
| nerve | 1 / 15768 | 63 | |
| ovary | 2 / 102051 | 19 | |
| pancreas | 0 / 214812 | 0 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 1 / 16585 | 60 | |
| placenta | 17 / 280825 | 60 | |
| prostate | 6 / 189345 | 31 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 7 / 210574 | 33 | |
| spleen | 3 / 53952 | 55 | |
| stomach | 2 / 96619 | 20 | |
| testis | 17 / 330442 | 51 | |
| thymus | 7 / 81131 | 86 | |
| thyroid | 4 / 47473 | 84 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 1 / 52413 | 19 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 11 / 232878 | 47 | |
| vascular | 2 / 51780 | 38 | |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 211541_s_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 5.6 | |
| Adipocyte | 4.6 | |
| AdrenalCortex | 5 | |
| Adrenalgland | 4.15 | |
| Amygdala | 5 | |
| Appendix | 5.15 | |
| AtrioventricularNode | 3.5 | |
| BDCA4+_DentriticCells | 5 | |
| Bonemarrow | 5.1 | |
| BronchialEpithelialCells | 4.55 | |
| CD105+_Endothelial | 4.65 | |
| CD14+_Monocytes | 4.95 | |
| CD19+_BCells(neg._sel.) | 4.85 | |
| CD33+_Myeloid | 5.8 | |
| CD34+ | 5.8 | |
| CD4+_Tcells | 4.95 | |
| CD56+_NKCells | 5.4 | |
| CD71+_EarlyErythroid | 4.4 | |
| CD8+_Tcells | 4.4 | |
| CardiacMyocytes | 6.5 | |
| Caudatenucleus | 4.25 | |
| Cerebellum | 3.9 | |
| CerebellumPeduncles | 5.45 | |
| CiliaryGanglion | 3.3 | |
| CingulateCortex | 5.75 | |
| Colorectaladenocarcinoma | 4.7 | |
| DorsalRootGanglion | 3.95 | |
| FetalThyroid | 5.15 | |
| Fetalbrain | 4.7 | |
| Fetalliver | 4.15 | |
| Fetallung | 3.8 | |
| GlobusPallidus | 3.45 | |
| Heart | 6.55 | |
| Hypothalamus | 5.1 | |
| Kidney | 3.95 | |
| Leukemia_chronicMyelogenousK-562 | 4.25 | |
| Leukemia_promyelocytic-HL-60 | 4.2 | |
| Leukemialymphoblastic(MOLT-4) | 3.7 | |
| Liver | 6.8 | |
| Lung | 5.1 | |
| Lymphnode | 3.95 | |
| Lymphoma_burkitts(Daudi) | 6.1 | |
| Lymphoma_burkitts(Raji) | 6.8 | |
| MedullaOblongata | 4.3 | |
| OccipitalLobe | 4.25 | |
| OlfactoryBulb | 3.7 | |
| Ovary | 3.35 | |
| Pancreas | 5.85 | |
| PancreaticIslet | 5.15 | |
| ParietalLobe | 5.3 | |
| Pituitary | 5.5 | |
| Placenta | 4.75 | |
| Pons | 4.55 | |
| PrefrontalCortex | 5.65 | |
| Prostate | 5.45 | |
| Salivarygland | 3.85 | |
| SkeletalMuscle | 11.1 | |
| Skin | 3.6 | |
| SmoothMuscle | 5.25 | |
| Spinalcord | 5.05 | |
| SubthalamicNucleus | 4.3 | |
| SuperiorCervicalGanglion | 6.7 | |
| TemporalLobe | 4.3 | |
| Testis | 4.1 | |
| TestisGermCell | 4.15 | |
| TestisIntersitial | 4.15 | |
| TestisLeydigCell | 4.85 | |
| TestisSeminiferousTubule | 4.05 | |
| Thalamus | 4.8 | |
| Thymus | 3.75 | |
| Thyroid | 5.8 | |
| Tongue | 4.9 | |
| Tonsil | 4.6 | |
| Trachea | 4.6 | |
| TrigeminalGanglion | 5.4 | |
| Uterus | 3.85 | |
| UterusCorpus | 4.9 | |
| WholeBlood | 5.15 | |
| Wholebrain | 3.95 | |
| colon | 4.75 | |
| pineal_day | 5.74 | |
| pineal_night | 5.62 | |
| retina | 5.625 | |
| small_intestine | 4.55 | |
- Probe name: A_24_P322753
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 7.1 ± 0.45 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 7.25 ± 0.25 | |
| Basal Part of Pons | 7.15 ± 0.36 | |
| Cerebellar Cortex | 7.52 ± 0.3 | |
| Cerebellar Nuclei | 7.14 ± 0.38 | |
| Claustrum | 7.08 ± 0.46 | |
| Epithalamus | 7.45 ± 0.28 | |
| Frontal Lobe | 7.31 ± 0.38 | |
| Globus Pallidus | 6.71 ± 0.26 | |
| Hypothalamus | 7.5 ± 0.32 | |
| Insula | 7.35 ± 0.34 | |
| Limbic Lobe | 7.25 ± 0.45 | |
| Mesencephalon | 7.16 ± 0.45 | |
| Myelencephalon | 7.19 ± 0.46 | |
| Occipital Lobe | 6.93 ± 0.49 | |
| Parietal Lobe | 7.32 ± 0.41 | |
| Pontine Tegmentum | 7.28 ± 0.46 | |
| Striatum | 6.74 ± 0.44 | |
| Subthalamus | 7.29 ± 0.37 | |
| Temporal Lobe | 7.38 ± 0.37 | |
| Thalamus | 7.18 ± 0.37 | |
| White Matter | 7.2 ± 0.23 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Dyrk1a | CB | Cerebellum | 100 | |
| 100 | | |||
| Dyrk1a | CTX | Cerebral cortex | 100 | |
| 100 | | |||
| Dyrk1a | HIP | Hippocampal region | 100 | |
| 100 | | |||
| Dyrk1a | HPF | Hippocampal formation | 100 | |
| 100 | | |||
| Dyrk1a | HY | Hypothalamus | 84.04 | |
| 73.44 | | |||
| Dyrk1a | LSX | Lateral septal complex | 92.63 | |
| 75.7 | | |||
| Dyrk1a | MB | Midbrain | 91.83 | |
| 82.06 | | |||
| Dyrk1a | MY | Medulla | 89.07 | |
| 84.7 | | |||
| Dyrk1a | OLF | Olfactory bulb | 100 | |
| 100 | | |||
| Dyrk1a | P | Pons | 86.23 | |
| 79.39 | | |||
| Dyrk1a | PAL | Pallidum | 86.1 | |
| 77.6 | | |||
| Dyrk1a | RHP | Retrohippocampal region | 100 | |
| 91.45 | | |||
| Dyrk1a | sAMY | Striatum-like amygdalar nuclei | 100 | |
| 84.64 | | |||
| Dyrk1a | STR | Striatum | 99.45 | |
| 81.79 | | |||
| Dyrk1a | STRd | Striatum dorsal region | 97.42 | |
| 79.96 | | |||
| Dyrk1a | STRv | Striatum ventral region | 100 | |
| 88.87 | | |||
| Dyrk1a | TH | Thalamus | 97.26 | |
| 89.17 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| PAp00069778 | 23 | 528 | 550 | HSGGHFTAAVQAMDCETHSPQVR | Peptide Atlas |