Annotation Detail for E2F4
Basic Information Top
| Gene Symbol: | E2F4 ( E2F-4 ) |
|---|---|
| Gene Full Name: | E2F transcription factor 4, p107/p130-binding |
| Band: | 16q22.1 |
| Quick Links | Entrez ID:1874; OMIM: 600659; Uniprot ID:E2F4_HUMAN; ENSEMBL ID: ENSG00000205250; HGNC ID: 3118 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.108371
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 3 / 70761 | 42 |  |
| blastocyst | 3 / 62319 | 48 | |
| fetus | 36 / 564012 | 63 |  |
| neonate | 0 / 31097 | 0 | |
| infant | 1 / 23620 | 42 | |
| juvenile | 0 / 55556 | 0 | |
| adult | 132 / 1939121 | 68 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 3 / 17475 | 171 | |
| breast (mammary gland) tumor | 4 / 94178 | 42 | |
| cervical tumor | 5 / 34366 | 145 | |
| chondrosarcoma | 4 / 82823 | 48 | |
| colorectal tumor | 6 / 114246 | 52 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 18 / 119369 | 150 | |
| germ cell tumor | 15 / 263845 | 56 | |
| glioma | 6 / 106883 | 56 | |
| head and neck tumor | 6 / 136302 | 44 | |
| kidney tumor | 4 / 68959 | 58 | |
| leukemia | 5 / 95842 | 52 | |
| liver tumor | 7 / 96359 | 72 | |
| lung tumor | 5 / 103127 | 48 | |
| lymphoma | 4 / 71755 | 55 | |
| non-neoplasia | 3 / 97250 | 30 | |
| normal | 162 / 3360307 | 48 | |
| ovarian tumor | 1 / 76682 | 13 | |
| pancreatic tumor | 6 / 104616 | 57 | |
| primitive neuroectodermal tumor of the CNS | 5 / 125680 | 39 | |
| prostate cancer | 6 / 102680 | 58 | |
| retinoblastoma | 3 / 46356 | 64 | |
| skin tumor | 13 / 124949 | 104 | |
| soft tissue/muscle tissue tumor | 9 / 125191 | 71 | |
| uterine tumor | 4 / 90257 | 44 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 1 / 13106 | 76 | |
| adrenal gland | 1 / 33197 | 30 | |
| ascites | 10 / 40015 | 249 |  |
| bladder | 1 / 29757 | 33 | |
| blood | 8 / 123478 | 64 | |
| bone | 2 / 71655 | 27 | |
| bone marrow | 5 / 48801 | 102 | |
| brain | 28 / 1100989 | 25 | |
| cervix | 10 / 48171 | 207 | |
| connective tissue | 3 / 149255 | 20 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 11 / 215722 | 50 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 13 / 211054 | 61 | |
| heart | 1 / 89626 | 11 | |
| intestine | 13 / 234472 | 55 | |
| kidney | 6 / 211777 | 28 | |
| larynx | 0 / 24145 | 0 | |
| liver | 8 / 207743 | 38 | |
| lung | 14 / 336974 | 41 | |
| lymph | 2 / 44270 | 45 | |
| lymph node | 12 / 91610 | 130 | |
| mammary gland | 6 / 153271 | 39 | |
| mouth | 2 / 67052 | 29 | |
| muscle | 3 / 107715 | 27 | |
| nerve | 3 / 15768 | 190 | |
| ovary | 3 / 102051 | 29 | |
| pancreas | 9 / 214812 | 41 | |
| parathyroid | 3 / 20539 | 146 | |
| pharynx | 1 / 41328 | 24 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 28 / 280825 | 99 | |
| prostate | 7 / 189345 | 36 | |
| salivary gland | 1 / 20155 | 49 | |
| skin | 15 / 210574 | 71 | |
| spleen | 0 / 53952 | 0 | |
| stomach | 7 / 96619 | 72 | |
| testis | 9 / 330442 | 27 | |
| thymus | 0 / 81131 | 0 | |
| thyroid | 3 / 47473 | 63 | |
| tonsil | 1 / 16999 | 58 | |
| trachea | 0 / 52413 | 0 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 13 / 232878 | 55 | |
| vascular | 2 / 51780 | 38 | |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 38707_r_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 1.15 |  |
| Adipocyte | 0.85 |  |
| AdrenalCortex | 0.8 | |
| Adrenalgland | 0.7 | |
| Amygdala | 0.85 | |
| Appendix | 0.75 | |
| AtrioventricularNode | 0.55 | |
| BDCA4+_DentriticCells | 0.9 | |
| Bonemarrow | 0.85 | |
| BronchialEpithelialCells | 0.8 | |
| CD105+_Endothelial | 1 | |
| CD14+_Monocytes | 0.8 | |
| CD19+_BCells(neg._sel.) | 0.85 | |
| CD33+_Myeloid | 1.05 | |
| CD34+ | 0.95 | |
| CD4+_Tcells | 0.9 | |
| CD56+_NKCells | 0.95 | |
| CD71+_EarlyErythroid | 6.9 | |
| CD8+_Tcells | 0.8 | |
| CardiacMyocytes | 1 | |
| Caudatenucleus | 0.75 | |
| Cerebellum | 0.65 | |
| CerebellumPeduncles | 0.9 | |
| CiliaryGanglion | 0.55 | |
| CingulateCortex | 0.8 | |
| Colorectaladenocarcinoma | 0.8 | |
| DorsalRootGanglion | 0.75 | |
| FetalThyroid | 0.8 | |
| Fetalbrain | 0.8 | |
| Fetalliver | 0.7 | |
| Fetallung | 0.7 | |
| GlobusPallidus | 0.55 | |
| Heart | 1 | |
| Hypothalamus | 0.9 | |
| Kidney | 0.65 | |
| Leukemia_chronicMyelogenousK-562 | 0.75 | |
| Leukemia_promyelocytic-HL-60 | 0.7 | |
| Leukemialymphoblastic(MOLT-4) | 0.65 | |
| Liver | 1.1 | |
| Lung | 0.9 | |
| Lymphnode | 0.7 | |
| Lymphoma_burkitts(Daudi) | 1 | |
| Lymphoma_burkitts(Raji) | 1.1 | |
| MedullaOblongata | 0.8 | |
| OccipitalLobe | 0.7 | |
| OlfactoryBulb | 0.65 | |
| Ovary | 0.55 | |
| Pancreas | 0.6 | |
| PancreaticIslet | 0.9 | |
| ParietalLobe | 0.85 | |
| Pituitary | 0.9 | |
| Placenta | 0.85 | |
| Pons | 0.75 | |
| PrefrontalCortex | 1.05 | |
| Prostate | 0.95 | |
| Salivarygland | 0.65 | |
| SkeletalMuscle | 1.15 | |
| Skin | 0.7 | |
| SmoothMuscle | 0.9 | |
| Spinalcord | 0.9 | |
| SubthalamicNucleus | 0.7 | |
| SuperiorCervicalGanglion | 0.85 | |
| TemporalLobe | 0.75 | |
| Testis | 0.7 | |
| TestisGermCell | 0.7 | |
| TestisIntersitial | 0.7 | |
| TestisLeydigCell | 0.8 | |
| TestisSeminiferousTubule | 0.7 | |
| Thalamus | 0.8 | |
| Thymus | 0.65 | |
| Thyroid | 1.05 | |
| Tongue | 0.8 | |
| Tonsil | 0.75 | |
| Trachea | 0.7 | |
| TrigeminalGanglion | 0.75 | |
| Uterus | 0.65 | |
| UterusCorpus | 0.7 | |
| WholeBlood | 0.9 | |
| Wholebrain | 0.75 | |
| colon | 0.85 | |
| pineal_day | 1 | |
| pineal_night | 0.94 | |
| retina | 1.025 | |
| small_intestine | 0.75 | |
- Probe name: A_23_P152218
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 3.87 ± 0.63 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 3.33 ± 0.4 | |
| Basal Part of Pons | 3.83 ± 0.59 | |
| Cerebellar Cortex | 3.83 ± 0.72 | |
| Cerebellar Nuclei | 3.54 ± 0.47 | |
| Claustrum | 3.42 ± 0.66 | |
| Epithalamus | 3.4 ± 0.63 | |
| Frontal Lobe | 3.95 ± 0.58 | |
| Globus Pallidus | 2.94 ± 0.73 | |
| Hypothalamus | 3.34 ± 0.77 | |
| Insula | 3.74 ± 0.49 | |
| Limbic Lobe | 3.93 ± 0.61 | |
| Mesencephalon | 3.66 ± 0.66 | |
| Myelencephalon | 3.7 ± 0.7 | |
| Occipital Lobe | 3.19 ± 0.8 | |
| Parietal Lobe | 3.71 ± 0.57 | |
| Pontine Tegmentum | 3.6 ± 0.58 | |
| Striatum | 3.21 ± 0.66 | |
| Subthalamus | 3.4 ± 0.72 | |
| Temporal Lobe | 3.92 ± 0.55 | |
| Thalamus | 3.63 ± 0.67 | |
| White Matter | 2.07 ± 0.29 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| E2f4 | CB | Cerebellum | 55.74 | |
| 57.7 | | |||
| E2f4 | CTX | Cerebral cortex | 76.54 | |
| 53.7 | | |||
| E2f4 | HIP | Hippocampal region | 62.16 | |
| 69.57 | | |||
| E2f4 | HPF | Hippocampal formation | 63.93 | |
| 58.36 | | |||
| E2f4 | HY | Hypothalamus | 36.3 | |
| 22.94 | | |||
| E2f4 | LSX | Lateral septal complex | 52.19 | |
| 30.67 | | |||
| E2f4 | MB | Midbrain | 37.64 | |
| 27.52 | | |||
| E2f4 | MY | Medulla | 53.39 | |
| 49.15 | | |||
| E2f4 | OLF | Olfactory bulb | 82.9 | |
| 66.23 | | |||
| E2f4 | P | Pons | 38.19 | |
| 30.68 | | |||
| E2f4 | PAL | Pallidum | 31.89 | |
| 22.55 | | |||
| E2f4 | RHP | Retrohippocampal region | 62.24 | |
| 48.81 | | |||
| E2f4 | sAMY | Striatum-like amygdalar nuclei | 46.51 | |
| 28.55 | | |||
| E2f4 | STR | Striatum | 52.6 | |
| 30 | | |||
| E2f4 | STRd | Striatum dorsal region | 53.25 | |
| 30.01 | | |||
| E2f4 | STRv | Striatum ventral region | 57.43 | |
| 31.89 | | |||
| E2f4 | TH | Thalamus | 48.74 | |
| 34.25 | |
Peptide