AutismKB 2.0

Annotation Detail for E4F1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:E4F1 ( E4F,MGC99614 )
Gene Full Name: E4F transcription factor 1
Band: 16p13.3
Quick LinksEntrez ID:1877; OMIM: 603022; Uniprot ID:E4F1_HUMAN; ENSEMBL ID: ENSG00000167967; HGNC ID: 3121
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst1 / 6231916
fetus6 / 56401210
neonate0 / 310970 
infant2 / 2362084
juvenile0 / 555560 
adult54 / 193912127
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus0 / 5640120 
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult2 / 19391211
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor1 / 3436629
chondrosarcoma1 / 8282312
colorectal tumor5 / 11424643
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor6 / 26384522
glioma4 / 10688337
head and neck tumor4 / 13630229
kidney tumor2 / 6895929
leukemia4 / 9584241
liver tumor1 / 9635910
lung tumor7 / 10312767
lymphoma1 / 7175513
non-neoplasia0 / 972500 
normal72 / 336030721
ovarian tumor5 / 7668265
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS10 / 12568079
prostate cancer2 / 10268019
retinoblastoma3 / 4635664
skin tumor6 / 12494948
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor7 / 9025777
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor1 / 2638453
glioma1 / 1068839
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal2 / 33603070 
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland0 / 331970 
ascites1 / 4001524
bladder0 / 297570 
blood1 / 1234788
bone3 / 7165541
bone marrow2 / 4880140
brain22 / 110098919
cervix1 / 4817120
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus0 / 202090 
eye14 / 21105466
heart1 / 8962611
intestine6 / 23447225
kidney8 / 21177737
larynx0 / 241450 
liver2 / 2077439
lung10 / 33697429
lymph0 / 442700 
lymph node7 / 9161076
mammary gland3 / 15327119
mouth4 / 6705259
muscle1 / 1077159
nerve1 / 1576863
ovary6 / 10205158
pancreas9 / 21481241
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta8 / 28082528
prostate13 / 18934568
salivary gland0 / 201550 
skin7 / 21057433
spleen0 / 539520 
stomach1 / 9661910
testis7 / 33044221
thymus0 / 811310 
thyroid0 / 474730 
tonsil2 / 16999117
trachea0 / 524130 
umbilical cord0 / 136800 
uterus15 / 23287864
vascular0 / 517800 
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain1 / 11009890 
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye2 / 2110549
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis1 / 3304423
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218524_at
Cell line Expression level Expression bar
721_B_lymphoblasts13.5
Adipocyte8.25
AdrenalCortex9.3
Adrenalgland6.65
Amygdala8.5
Appendix7.35
AtrioventricularNode6.1
BDCA4+_DentriticCells20.25
Bonemarrow7.9
BronchialEpithelialCells7.75
CD105+_Endothelial11.1
CD14+_Monocytes15
CD19+_BCells(neg._sel.)17.25
CD33+_Myeloid16.7
CD34+14.45
CD4+_Tcells42.25
CD56+_NKCells26.35
CD71+_EarlyErythroid16.85
CD8+_Tcells34.9
CardiacMyocytes11.55
Caudatenucleus7.2
Cerebellum6.5
CerebellumPeduncles9.95
CiliaryGanglion6.05
CingulateCortex8.4
Colorectaladenocarcinoma9.3
DorsalRootGanglion6.5
FetalThyroid8.05
Fetalbrain8.4
Fetalliver6.25
Fetallung6.35
GlobusPallidus6.05
Heart13.75
Hypothalamus8.6
Kidney6.2
Leukemia_chronicMyelogenousK-56210.1
Leukemia_promyelocytic-HL-607.4
Leukemialymphoblastic(MOLT-4)8.05
Liver12.95
Lung18.3
Lymphnode7.1
Lymphoma_burkitts(Daudi)11.25
Lymphoma_burkitts(Raji)17.3
MedullaOblongata6.65
OccipitalLobe7.35
OlfactoryBulb6
Ovary5.45
Pancreas6.7
PancreaticIslet8.35
ParietalLobe8.85
Pituitary9.45
Placenta8.85
Pons7.95
PrefrontalCortex10.15
Prostate14.75
Salivarygland6.5
SkeletalMuscle10.6
Skin6.45
SmoothMuscle7.65
Spinalcord10.35
SubthalamicNucleus7.45
SuperiorCervicalGanglion8.25
TemporalLobe8.45
Testis8.7
TestisGermCell6.8
TestisIntersitial7.05
TestisLeydigCell7.7
TestisSeminiferousTubule7.05
Thalamus9.2
Thymus9.15
Thyroid23.8
Tongue8.15
Tonsil9.05
Trachea6.7
TrigeminalGanglion8.25
Uterus7.2
UterusCorpus8.05
WholeBlood9.05
Wholebrain6.75
colon8.25
pineal_day12.08
pineal_night10.1
retina10.525
small_intestine7.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1594_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.28 ± 0.82
Basal Forebrain5.66 ± 0.33
Basal Part of Pons5.98 ± 0.8
Cerebellar Cortex6.2 ± 0.4
Cerebellar Nuclei5.2 ± 0.39
Claustrum4.87 ± 1.03
Epithalamus5.87 ± 0.66
Frontal Lobe5.87 ± 0.62
Globus Pallidus4.99 ± 0.32
Hypothalamus5.55 ± 0.69
Insula5.89 ± 0.31
Limbic Lobe5.56 ± 0.71
Mesencephalon5.5 ± 0.55
Myelencephalon5.61 ± 0.64
Occipital Lobe5.2 ± 0.59
Parietal Lobe5.63 ± 0.57
Pontine Tegmentum5.52 ± 0.64
Striatum4.93 ± 0.53
Subthalamus5.66 ± 0.28
Temporal Lobe5.86 ± 0.55
Thalamus5.68 ± 0.62
White Matter5.58 ± 0.52
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
E4f1CBCerebellum7.55
6.22
E4f1CTXCerebral cortex12.69
6.53
E4f1HIPHippocampal region24.07
12.8
E4f1HPFHippocampal formation25.69
13.96
E4f1HYHypothalamus8.25
4.53
E4f1LSXLateral septal complex4.19
2.44
E4f1MBMidbrain7.5
4.48
E4f1MYMedulla12.88
9.39
E4f1OLFOlfactory bulb22.54
12.26
E4f1PPons9.25
6.22
E4f1PALPallidum5.58
3.1
E4f1RHPRetrohippocampal region27.06
14.75
E4f1sAMYStriatum-like amygdalar nuclei8.51
4.36
E4f1STRStriatum2.86
1.44
E4f1STRdStriatum dorsal region1.87
0.95
E4f1STRvStriatum ventral region2.75
1.12
E4f1THThalamus7.35
4.11
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved