AutismKB 2.0

Annotation Detail for ECT2


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Basic Information Top
Gene Symbol:ECT2 ( ARHGEF31,FLJ10461,MGC138291 )
Gene Full Name: epithelial cell transforming sequence 2 oncogene
Band: 3q26.31
Quick LinksEntrez ID:1894; OMIM: 600586; Uniprot ID:ECT2_HUMAN; ENSEMBL ID: ENSG00000114346; HGNC ID: 3155
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst9 / 62319144
fetus21 / 56401237
neonate3 / 3109796
infant1 / 2362042
juvenile2 / 5555635
adult102 / 193912152
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma4 / 17475228
breast (mammary gland) tumor10 / 94178106
cervical tumor4 / 34366116
chondrosarcoma5 / 8282360
colorectal tumor18 / 114246157
esophageal tumor4 / 17290231
gastrointestinal tumor14 / 119369117
germ cell tumor40 / 263845151
glioma4 / 10688337
head and neck tumor24 / 136302176
kidney tumor4 / 6895958
leukemia6 / 9584262
liver tumor6 / 9635962
lung tumor4 / 10312738
lymphoma4 / 7175555
non-neoplasia1 / 9725010
normal89 / 336030726
ovarian tumor1 / 7668213
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer3 / 10268029
retinoblastoma6 / 46356129
skin tumor5 / 12494940
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites8 / 40015199
bladder4 / 29757134
blood2 / 12347816
bone1 / 7165513
bone marrow7 / 48801143
brain35 / 110098931
cervix4 / 4817183
connective tissue8 / 14925553
ear0 / 162120 
embryonic tissue18 / 21572283
esophagus4 / 20209197
eye6 / 21105428
heart2 / 8962622
intestine25 / 234472106
kidney6 / 21177728
larynx1 / 2414541
liver7 / 20774333
lung9 / 33697426
lymph0 / 442700 
lymph node9 / 9161098
mammary gland19 / 153271123
mouth19 / 67052283
muscle1 / 1077159
nerve2 / 15768126
ovary1 / 1020519
pancreas2 / 2148129
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta6 / 28082521
prostate4 / 18934521
salivary gland2 / 2015599
skin8 / 21057437
spleen0 / 539520 
stomach3 / 9661931
testis62 / 330442187
thymus7 / 8113186
thyroid3 / 4747363
tonsil0 / 169990 
trachea8 / 52413152
umbilical cord0 / 136800 
uterus8 / 23287834
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219787_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts142.5
Adipocyte7.8
AdrenalCortex10.75
Adrenalgland7.45
Amygdala8.05
Appendix10.15
AtrioventricularNode8.9
BDCA4+_DentriticCells7.65
Bonemarrow9.25
BronchialEpithelialCells10.5
CD105+_Endothelial49.35
CD14+_Monocytes8.65
CD19+_BCells(neg._sel.)8.1
CD33+_Myeloid9.55
CD34+10.1
CD4+_Tcells7.85
CD56+_NKCells8.8
CD71+_EarlyErythroid142.15
CD8+_Tcells6.95
CardiacMyocytes18.65
Caudatenucleus7.25
Cerebellum6.75
CerebellumPeduncles10.05
CiliaryGanglion8.25
CingulateCortex8.65
Colorectaladenocarcinoma110.8
DorsalRootGanglion7.65
FetalThyroid8.25
Fetalbrain7.55
Fetalliver11.75
Fetallung5.95
GlobusPallidus6.7
Heart14.35
Hypothalamus8.3
Kidney7.65
Leukemia_chronicMyelogenousK-56218.4
Leukemia_promyelocytic-HL-6015.45
Leukemialymphoblastic(MOLT-4)12.25
Liver12.95
Lung8.7
Lymphnode6.45
Lymphoma_burkitts(Daudi)20.6
Lymphoma_burkitts(Raji)20.8
MedullaOblongata7
OccipitalLobe7.1
OlfactoryBulb6.15
Ovary6.4
Pancreas7
PancreaticIslet8.8
ParietalLobe9.4
Pituitary9.35
Placenta7.7
Pons8.2
PrefrontalCortex9.3
Prostate8.95
Salivarygland6.95
SkeletalMuscle13.05
Skin7.9
SmoothMuscle9.15
Spinalcord8.45
SubthalamicNucleus8
SuperiorCervicalGanglion14.45
TemporalLobe7.75
Testis6.85
TestisGermCell6.25
TestisIntersitial7.1
TestisLeydigCell9.3
TestisSeminiferousTubule6.9
Thalamus8.55
Thymus6
Thyroid9.35
Tongue9.65
Tonsil8.15
Trachea6.6
TrigeminalGanglion10.7
Uterus6.25
UterusCorpus8.8
WholeBlood8.55
Wholebrain6.2
colon10.15
pineal_day9.68
pineal_night9.68
retina9.65
small_intestine8.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P366033
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.96 ± 1.03
Basal Forebrain2.56 ± 0.24
Basal Part of Pons2.43 ± 0.56
Cerebellar Cortex2.45 ± 0.68
Cerebellar Nuclei2.9 ± 0.64
Claustrum3.1 ± 0.62
Epithalamus2.16 ± 0.82
Frontal Lobe2.45 ± 0.73
Globus Pallidus3.1 ± 0.62
Hypothalamus2.66 ± 0.73
Insula2.56 ± 0.6
Limbic Lobe2.52 ± 0.62
Mesencephalon2.7 ± 0.68
Myelencephalon2.54 ± 0.67
Occipital Lobe2.47 ± 0.7
Parietal Lobe2.55 ± 0.67
Pontine Tegmentum2.53 ± 0.71
Striatum2.62 ± 0.72
Subthalamus2.72 ± 0.73
Temporal Lobe2.46 ± 0.64
Thalamus2.48 ± 0.58
White Matter3.73 ± 0.9
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ect2CBCerebellum3.41
5.3
Ect2CTXCerebral cortex18.97
14.94
Ect2HIPHippocampal region19.77
22.06
Ect2HPFHippocampal formation17.14
17.45
Ect2HYHypothalamus10.02
7.79
Ect2LSXLateral septal complex14.02
12.79
Ect2MBMidbrain2.66
3.58
Ect2MYMedulla0.82
1.65
Ect2OLFOlfactory bulb10.64
8.64
Ect2PPons3.76
9.42
Ect2PALPallidum13.18
11.87
Ect2RHPRetrohippocampal region12.64
10.87
Ect2sAMYStriatum-like amygdalar nuclei11.63
8.52
Ect2STRStriatum8.46
7.01
Ect2STRdStriatum dorsal region6.84
6.08
Ect2STRvStriatum ventral region11.57
8.05
Ect2THThalamus20.1
16.87
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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