AutismKB 2.0

Annotation Detail for S1PR1


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Basic Information Top
Gene Symbol:S1PR1 ( CHEDG1,D1S3362,ECGF1,EDG-1,EDG1,FLJ58121,S1P1 )
Gene Full Name: sphingosine-1-phosphate receptor 1
Band: 1p21.2
Quick LinksEntrez ID:1901; OMIM: 601974; Uniprot ID:S1PR1_HUMAN; ENSEMBL ID: ENSG00000170989; HGNC ID: 3165
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus8 / 56401214
neonate2 / 3109764
infant0 / 236200 
juvenile0 / 555560 
adult50 / 193912125
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor0 / 2638450 
glioma1 / 1068839
head and neck tumor2 / 13630214
kidney tumor1 / 6895914
leukemia15 / 95842156
liver tumor3 / 9635931
lung tumor0 / 1031270 
lymphoma2 / 7175527
non-neoplasia1 / 9725010
normal118 / 336030735
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood7 / 12347856
bone0 / 716550 
bone marrow3 / 4880161
brain55 / 110098949
cervix0 / 481710 
connective tissue8 / 14925553
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye5 / 21105423
heart4 / 8962644
intestine1 / 2344724
kidney9 / 21177742
larynx0 / 241450 
liver4 / 20774319
lung11 / 33697432
lymph0 / 442700 
lymph node17 / 91610185
mammary gland2 / 15327113
mouth1 / 6705214
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas8 / 21481237
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta8 / 28082528
prostate2 / 18934510
salivary gland0 / 201550 
skin0 / 2105740 
spleen1 / 5395218
stomach1 / 9661910
testis2 / 3304426
thymus13 / 81131160
thyroid1 / 4747321
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord1 / 1368073
uterus6 / 23287825
vascular13 / 51780251
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204642_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.55
Adipocyte8.95
AdrenalCortex10.95
Adrenalgland35.25
Amygdala15.65
Appendix25.2
AtrioventricularNode10.55
BDCA4+_DentriticCells9.75
Bonemarrow10.55
BronchialEpithelialCells6.35
CD105+_Endothelial9.55
CD14+_Monocytes7.95
CD19+_BCells(neg._sel.)58.15
CD33+_Myeloid10.3
CD34+9.85
CD4+_Tcells41.35
CD56+_NKCells37.1
CD71+_EarlyErythroid7.95
CD8+_Tcells35.9
CardiacMyocytes16.5
Caudatenucleus13.3
Cerebellum62.9
CerebellumPeduncles18.2
CiliaryGanglion8.6
CingulateCortex15.85
Colorectaladenocarcinoma9.05
DorsalRootGanglion9.3
FetalThyroid8.75
Fetalbrain11.1
Fetalliver9.5
Fetallung46.2
GlobusPallidus10.7
Heart16.9
Hypothalamus14.5
Kidney9.8
Leukemia_chronicMyelogenousK-5628.4
Leukemia_promyelocytic-HL-608.25
Leukemialymphoblastic(MOLT-4)7.2
Liver15.85
Lung31.05
Lymphnode12.75
Lymphoma_burkitts(Daudi)10.9
Lymphoma_burkitts(Raji)12.4
MedullaOblongata9
OccipitalLobe12.25
OlfactoryBulb8.05
Ovary7.4
Pancreas7.95
PancreaticIslet10.85
ParietalLobe11.05
Pituitary10.75
Placenta21.25
Pons10.45
PrefrontalCortex17.15
Prostate11.15
Salivarygland8.7
SkeletalMuscle16.2
Skin13.25
SmoothMuscle8.6
Spinalcord14.35
SubthalamicNucleus9.15
SuperiorCervicalGanglion15.4
TemporalLobe10.5
Testis7.65
TestisGermCell6.9
TestisIntersitial6.6
TestisLeydigCell9.35
TestisSeminiferousTubule7.35
Thalamus10.7
Thymus7.35
Thyroid12.15
Tongue11.75
Tonsil9.8
Trachea12.9
TrigeminalGanglion12.15
Uterus8.85
UterusCorpus9.65
WholeBlood38.85
Wholebrain8.25
colon10.1
pineal_day10.5
pineal_night10.42
retina15.5
small_intestine16.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15847_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.28 ± 0.86
Basal Forebrain2.99 ± 0.52
Basal Part of Pons3 ± 0.74
Cerebellar Cortex3.11 ± 0.67
Cerebellar Nuclei3.16 ± 0.54
Claustrum3.47 ± 0.7
Epithalamus3.12 ± 0.56
Frontal Lobe3.08 ± 0.66
Globus Pallidus3.95 ± 0.78
Hypothalamus3.07 ± 0.75
Insula3.16 ± 0.3
Limbic Lobe3.07 ± 0.7
Mesencephalon3.19 ± 0.64
Myelencephalon3.22 ± 0.63
Occipital Lobe3.17 ± 0.71
Parietal Lobe3.19 ± 0.61
Pontine Tegmentum3.25 ± 0.6
Striatum3.27 ± 0.56
Subthalamus2.79 ± 0.42
Temporal Lobe3.01 ± 0.68
Thalamus3.36 ± 0.6
White Matter2.56 ± 0.61
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Edg1CBCerebellum53.96
100
Edg1CTXCerebral cortex64.78
56.92
Edg1HIPHippocampal region76.56
70.15
Edg1HPFHippocampal formation83.17
69.94
Edg1HYHypothalamus61.45
42.4
Edg1LSXLateral septal complex100
85.76
Edg1MBMidbrain62.88
46.74
Edg1MYMedulla53.51
41.27
Edg1OLFOlfactory bulb96.75
78.8
Edg1PPons60.93
41.98
Edg1PALPallidum63.79
48.59
Edg1RHPRetrohippocampal region90.57
67.16
Edg1sAMYStriatum-like amygdalar nuclei75.67
62.23
Edg1STRStriatum70.12
61.32
Edg1STRdStriatum dorsal region61.71
55.59
Edg1STRvStriatum ventral region78.96
62.37
Edg1THThalamus35.22
25.34
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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