AutismKB 2.0

Annotation Detail for EIF2C3


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Basic Information Top
Gene Symbol:EIF2C3 ( AGO3,FLJ12765,MGC86946 )
Gene Full Name: eukaryotic translation initiation factor 2C, 3
Band: 1p34.3
Quick LinksEntrez ID:192669; OMIM: 607355; Uniprot ID:AGO3_HUMAN; ENSEMBL ID: ENSG00000126070; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst1 / 6231916
fetus7 / 56401212
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult29 / 193912114
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor6 / 11936950
germ cell tumor7 / 26384526
glioma1 / 1068839
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia1 / 9725010
normal42 / 336030712
ovarian tumor0 / 766820 
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites3 / 4001574
bladder1 / 2975733
blood2 / 12347816
bone2 / 7165527
bone marrow0 / 488010 
brain6 / 11009895
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus0 / 202090 
eye0 / 2110540 
heart1 / 8962611
intestine1 / 2344724
kidney5 / 21177723
larynx0 / 241450 
liver1 / 2077434
lung1 / 3369742
lymph1 / 4427022
lymph node7 / 9161076
mammary gland2 / 15327113
mouth1 / 6705214
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas8 / 21481237
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta3 / 28082510
prostate1 / 1893455
salivary gland0 / 201550 
skin2 / 2105749
spleen0 / 539520 
stomach3 / 9661931
testis16 / 33044248
thymus3 / 8113136
thyroid1 / 4747321
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus2 / 2328788
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219426_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.65
Adipocyte4.15
AdrenalCortex4.45
Adrenalgland8.45
Amygdala4.45
Appendix4.25
AtrioventricularNode3.25
BDCA4+_DentriticCells5.3
Bonemarrow4.05
BronchialEpithelialCells4.2
CD105+_Endothelial4.3
CD14+_Monocytes4.9
CD19+_BCells(neg._sel.)4.55
CD33+_Myeloid7.55
CD34+13.35
CD4+_Tcells5.75
CD56+_NKCells5.1
CD71+_EarlyErythroid3.95
CD8+_Tcells4.25
CardiacMyocytes5.45
Caudatenucleus3.8
Cerebellum3.45
CerebellumPeduncles4.65
CiliaryGanglion2.95
CingulateCortex4.3
Colorectaladenocarcinoma4.25
DorsalRootGanglion3.2
FetalThyroid4.5
Fetalbrain4.25
Fetalliver3.6
Fetallung3.55
GlobusPallidus3.1
Heart5.4
Hypothalamus4.65
Kidney3.35
Leukemia_chronicMyelogenousK-5625.3
Leukemia_promyelocytic-HL-603.75
Leukemialymphoblastic(MOLT-4)3.45
Liver5.55
Lung4.65
Lymphnode3.7
Lymphoma_burkitts(Daudi)5.4
Lymphoma_burkitts(Raji)5.8
MedullaOblongata3.9
OccipitalLobe3.8
OlfactoryBulb3.35
Ovary2.8
Pancreas3.4
PancreaticIslet4.5
ParietalLobe4.4
Pituitary46.3
Placenta4.4
Pons3.9
PrefrontalCortex12.75
Prostate5
Salivarygland3.3
SkeletalMuscle4.95
Skin3.2
SmoothMuscle4.75
Spinalcord4.55
SubthalamicNucleus3.75
SuperiorCervicalGanglion4.75
TemporalLobe3.85
Testis3.7
TestisGermCell4
TestisIntersitial3.9
TestisLeydigCell4.2
TestisSeminiferousTubule3.65
Thalamus4.25
Thymus15.1
Thyroid5.35
Tongue4.1
Tonsil4.1
Trachea3.55
TrigeminalGanglion4.45
Uterus5.35
UterusCorpus3.75
WholeBlood4.65
Wholebrain3.5
colon4.3
pineal_day5.48
pineal_night6.56
retina5.025
small_intestine4.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_8908_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.37 ± 0.72
Basal Forebrain5.83 ± 0.13
Basal Part of Pons5.56 ± 0.27
Cerebellar Cortex5.97 ± 0.26
Cerebellar Nuclei5.84 ± 0.32
Claustrum5.36 ± 0.64
Epithalamus5.92 ± 0.41
Frontal Lobe5.66 ± 0.38
Globus Pallidus6.05 ± 0.37
Hypothalamus5.98 ± 0.36
Insula5.63 ± 0.23
Limbic Lobe5.56 ± 0.36
Mesencephalon5.71 ± 0.41
Myelencephalon5.7 ± 0.43
Occipital Lobe5.87 ± 0.33
Parietal Lobe5.68 ± 0.36
Pontine Tegmentum5.73 ± 0.38
Striatum5.82 ± 0.37
Subthalamus5.48 ± 0.58
Temporal Lobe5.67 ± 0.32
Thalamus5.77 ± 0.33
White Matter7 ± 0.25
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Eif2c3CBCerebellum21.75
23.85
Eif2c3CTXCerebral cortex36.93
25.6
Eif2c3HIPHippocampal region38.73
45.51
Eif2c3HPFHippocampal formation35.05
35.22
Eif2c3HYHypothalamus17.17
12.14
Eif2c3LSXLateral septal complex54.68
42.2
Eif2c3MBMidbrain27.04
22.18
Eif2c3MYMedulla22.11
19.24
Eif2c3OLFOlfactory bulb31.12
23.47
Eif2c3PPons19.48
16.16
Eif2c3PALPallidum15.5
12.32
Eif2c3RHPRetrohippocampal region29.4
22.15
Eif2c3sAMYStriatum-like amygdalar nuclei9.96
6.69
Eif2c3STRStriatum15.75
10.69
Eif2c3STRdStriatum dorsal region12.55
8.38
Eif2c3STRvStriatum ventral region17.63
11.09
Eif2c3THThalamus15.3
12.6
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
AGO3_HUMAN_1 19 1 19 MEIGSAGPAGAQPLLMVPR PRIDE
PAp00025806 16 103 118 HTYLPLEVCNIVAGQR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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