AutismKB 2.0

Annotation Detail for EFNA5


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Basic Information Top
Gene Symbol:EFNA5 ( AF1,EFL5,EPLG7,GLC1M,LERK7,RAGS )
Gene Full Name: ephrin-A5
Band: 5q21.3
Quick LinksEntrez ID:1946; OMIM: 601535; Uniprot ID:EFNA5_HUMAN; ENSEMBL ID: ENSG00000184349; HGNC ID: 3225
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst3 / 6231948
fetus27 / 56401247
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult68 / 193912135
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma5 / 8282360
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor5 / 26384518
glioma0 / 1068830 
head and neck tumor2 / 13630214
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia4 / 9725041
normal71 / 336030721
ovarian tumor7 / 7668291
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer4 / 10268038
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone9 / 71655125
bone marrow0 / 488010 
brain10 / 11009899
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue7 / 21572232
esophagus0 / 202090 
eye4 / 21105418
heart1 / 8962611
intestine4 / 23447217
kidney12 / 21177756
larynx1 / 2414541
liver2 / 2077439
lung14 / 33697441
lymph0 / 442700 
lymph node0 / 916100 
mammary gland12 / 15327178
mouth0 / 670520 
muscle0 / 1077150 
nerve1 / 1576863
ovary9 / 10205188
pancreas8 / 21481237
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland2 / 16585120
placenta0 / 2808250 
prostate4 / 18934521
salivary gland0 / 201550 
skin6 / 21057428
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207301_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.25
Adipocyte4.25
AdrenalCortex4.65
Adrenalgland3.7
Amygdala4.45
Appendix5.95
AtrioventricularNode4.45
BDCA4+_DentriticCells4.6
Bonemarrow4.4
BronchialEpithelialCells4.15
CD105+_Endothelial4.35
CD14+_Monocytes4.45
CD19+_BCells(neg._sel.)4.55
CD33+_Myeloid5.55
CD34+5.35
CD4+_Tcells4.7
CD56+_NKCells5.1
CD71+_EarlyErythroid4.2
CD8+_Tcells4.1
CardiacMyocytes5.45
Caudatenucleus3.9
Cerebellum3.45
CerebellumPeduncles4.85
CiliaryGanglion4.3
CingulateCortex4.55
Colorectaladenocarcinoma4.3
DorsalRootGanglion4.1
FetalThyroid4.4
Fetalbrain4.3
Fetalliver3.75
Fetallung3.55
GlobusPallidus3.8
Heart5.6
Hypothalamus4.6
Kidney3.5
Leukemia_chronicMyelogenousK-5623.9
Leukemia_promyelocytic-HL-603.8
Leukemialymphoblastic(MOLT-4)3.35
Liver5.65
Lung4.65
Lymphnode3.65
Lymphoma_burkitts(Daudi)5.55
Lymphoma_burkitts(Raji)6.05
MedullaOblongata3.9
OccipitalLobe3.85
OlfactoryBulb3.4
Ovary2.9
Pancreas3.45
PancreaticIslet4.6
ParietalLobe4.55
Pituitary5.1
Placenta4.2
Pons4.15
PrefrontalCortex5.25
Prostate5
Salivarygland4.3
SkeletalMuscle5.65
Skin3.85
SmoothMuscle4.8
Spinalcord4.6
SubthalamicNucleus4.25
SuperiorCervicalGanglion5.4
TemporalLobe4.05
Testis3.65
TestisGermCell3.65
TestisIntersitial5.4
TestisLeydigCell4.55
TestisSeminiferousTubule4
Thalamus4.4
Thymus3.35
Thyroid5.3
Tongue4.7
Tonsil4.2
Trachea3.6
TrigeminalGanglion7.7
Uterus3.5
UterusCorpus7.5
WholeBlood4.65
Wholebrain3.6
colon4.3
pineal_day5.32
pineal_night5.24
retina5.375
small_intestine4.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P171200
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.65 ± 1.18
Basal Forebrain1.99 ± 0.24
Basal Part of Pons2.17 ± 0.88
Cerebellar Cortex1.96 ± 0.94
Cerebellar Nuclei2.44 ± 0.65
Claustrum3.17 ± 0.83
Epithalamus1.67 ± 0.93
Frontal Lobe2.29 ± 0.92
Globus Pallidus2.32 ± 0.63
Hypothalamus2.38 ± 0.59
Insula2.24 ± 0.85
Limbic Lobe2.07 ± 0.89
Mesencephalon2.25 ± 0.95
Myelencephalon2.18 ± 0.77
Occipital Lobe2.22 ± 0.63
Parietal Lobe2.38 ± 0.99
Pontine Tegmentum2.28 ± 0.89
Striatum1.93 ± 0.96
Subthalamus2.06 ± 0.87
Temporal Lobe1.94 ± 0.84
Thalamus2.13 ± 0.81
White Matter1.8 ± 0.2
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Efna5CBCerebellum22.59
29.3
Efna5CTXCerebral cortex81.2
69.98
Efna5HIPHippocampal region11.96
8.85
Efna5HPFHippocampal formation20.84
17.02
Efna5HYHypothalamus43.69
34.61
Efna5LSXLateral septal complex34.28
23.07
Efna5MBMidbrain20.38
16.91
Efna5MYMedulla20.09
20.2
Efna5OLFOlfactory bulb36.53
26.02
Efna5PPons19.24
18.69
Efna5PALPallidum20.58
17.32
Efna5RHPRetrohippocampal region34.92
27.03
Efna5sAMYStriatum-like amygdalar nuclei26.88
16.39
Efna5STRStriatum17.12
11.3
Efna5STRdStriatum dorsal region13.72
9.58
Efna5STRvStriatum ventral region16.6
9.66
Efna5THThalamus25.08
18.38
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00043225 14 100 113 WECNRPHSPNGPLK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018