AutismKB 2.0

Annotation Detail for CELSR3


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Basic Information Top
Gene Symbol:CELSR3 ( CDHF11,EGFL1,FMI1,HFMI1,MEGF2,RESDA1 )
Gene Full Name: cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
Band: 3p21.31
Quick LinksEntrez ID:1951; OMIM: 604264; Uniprot ID:CELR3_HUMAN; ENSEMBL ID: ENSG00000008300; HGNC ID: 3230
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus14 / 56401224
neonate0 / 310970 
infant1 / 2362042
juvenile2 / 5555635
adult23 / 193912111
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor1 / 3436629
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor3 / 26384511
glioma12 / 106883112
head and neck tumor3 / 13630222
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor3 / 10312729
lymphoma3 / 7175541
non-neoplasia1 / 9725010
normal50 / 336030714
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS7 / 12568055
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain44 / 110098939
cervix1 / 4817120
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye11 / 21105452
heart0 / 896260 
intestine6 / 23447225
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung16 / 33697447
lymph3 / 4427067
lymph node0 / 916100 
mammary gland3 / 15327119
mouth0 / 670520 
muscle0 / 1077150 
nerve1 / 1576863
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta5 / 28082517
prostate0 / 1893450 
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach1 / 9661910
testis1 / 3304423
thymus1 / 8113112
thyroid3 / 4747363
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 40020_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.75
Adipocyte6.3
AdrenalCortex8.55
Adrenalgland5.6
Amygdala10.55
Appendix7.65
AtrioventricularNode6.05
BDCA4+_DentriticCells6.15
Bonemarrow6.9
BronchialEpithelialCells5.95
CD105+_Endothelial5.95
CD14+_Monocytes6.5
CD19+_BCells(neg._sel.)6.3
CD33+_Myeloid7.3
CD34+7.4
CD4+_Tcells6.6
CD56+_NKCells6.7
CD71+_EarlyErythroid6.05
CD8+_Tcells6.1
CardiacMyocytes7.5
Caudatenucleus10.25
Cerebellum34.55
CerebellumPeduncles34.5
CiliaryGanglion5.05
CingulateCortex24.75
Colorectaladenocarcinoma8.3
DorsalRootGanglion6.15
FetalThyroid6.25
Fetalbrain97.9
Fetalliver5.9
Fetallung5.05
GlobusPallidus8.1
Heart8.05
Hypothalamus8.25
Kidney6.3
Leukemia_chronicMyelogenousK-5625.85
Leukemia_promyelocytic-HL-608.35
Leukemialymphoblastic(MOLT-4)5.25
Liver8.8
Lung6.65
Lymphnode5.2
Lymphoma_burkitts(Daudi)8.75
Lymphoma_burkitts(Raji)10.3
MedullaOblongata12.25
OccipitalLobe13.3
OlfactoryBulb5.05
Ovary4.2
Pancreas4.95
PancreaticIslet9.85
ParietalLobe7.4
Pituitary20.05
Placenta6.2
Pons8.4
PrefrontalCortex43.6
Prostate6.75
Salivarygland5.25
SkeletalMuscle8.45
Skin5.5
SmoothMuscle6.75
Spinalcord8.45
SubthalamicNucleus9.7
SuperiorCervicalGanglion8.2
TemporalLobe13.55
Testis10.15
TestisGermCell5.3
TestisIntersitial5.3
TestisLeydigCell6.75
TestisSeminiferousTubule6.2
Thalamus11.75
Thymus4.7
Thyroid7.45
Tongue7.1
Tonsil6.4
Trachea5.35
TrigeminalGanglion6.9
Uterus4.7
UterusCorpus6.15
WholeBlood6.55
Wholebrain12.55
colon6.1
pineal_day29.94
pineal_night17
retina7.75
small_intestine5.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9240_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.68 ± 0.82
Basal Forebrain8.67 ± 0.48
Basal Part of Pons8.57 ± 0.71
Cerebellar Cortex7.94 ± 0.55
Cerebellar Nuclei8.77 ± 0.6
Claustrum9.21 ± 0.86
Epithalamus7.79 ± 0.78
Frontal Lobe8.43 ± 0.67
Globus Pallidus9.1 ± 0.43
Hypothalamus8.49 ± 0.69
Insula8.22 ± 0.6
Limbic Lobe8.55 ± 0.68
Mesencephalon8.71 ± 0.58
Myelencephalon8.54 ± 0.69
Occipital Lobe8.39 ± 0.75
Parietal Lobe8.38 ± 0.65
Pontine Tegmentum8.21 ± 0.57
Striatum8.61 ± 0.65
Subthalamus8.02 ± 0.1
Temporal Lobe8.33 ± 0.72
Thalamus8.54 ± 0.58
White Matter8.85 ± 0.4
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Celsr3CBCerebellum62.01
74.93
Celsr3CTXCerebral cortex100
100
Celsr3HIPHippocampal region89.63
100
Celsr3HPFHippocampal formation95.05
100
Celsr3HYHypothalamus100
86.16
Celsr3LSXLateral septal complex100
99.72
Celsr3MBMidbrain86.62
74.25
Celsr3MYMedulla75.61
76.23
Celsr3OLFOlfactory bulb100
100
Celsr3PPons73.9
65.91
Celsr3PALPallidum85.06
72.99
Celsr3RHPRetrohippocampal region100
90.96
Celsr3sAMYStriatum-like amygdalar nuclei100
100
Celsr3STRStriatum100
83.67
Celsr3STRdStriatum dorsal region97.83
73.81
Celsr3STRvStriatum ventral region100
99.3
Celsr3THThalamus95.08
76.36
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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