AutismKB 2.0

Annotation Detail for EGR3


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Basic Information Top
Gene Symbol:EGR3 ( MGC138484,PILOT )
Gene Full Name: early growth response 3
Band: 8p21.3
Quick LinksEntrez ID:1960; OMIM: 602419; Uniprot ID:EGR3_HUMAN; ENSEMBL ID: ENSG00000179388; HGNC ID: 3240
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst2 / 6231932
fetus5 / 5640128
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult10 / 19391215
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma3 / 10688328
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal69 / 336030720
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood5 / 12347840
bone0 / 716550 
bone marrow0 / 488010 
brain51 / 110098946
cervix0 / 481710 
connective tissue3 / 14925520
ear3 / 16212185
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye1 / 2110544
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver2 / 2077439
lung13 / 33697438
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth0 / 670520 
muscle0 / 1077150 
nerve1 / 1576863
ovary0 / 1020510 
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin3 / 21057414
spleen1 / 5395218
stomach0 / 966190 
testis2 / 3304426
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus1 / 2328784
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206115_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.7
Adipocyte10
AdrenalCortex108.3
Adrenalgland11.65
Amygdala171.35
Appendix22.15
AtrioventricularNode13.95
BDCA4+_DentriticCells8.95
Bonemarrow11.8
BronchialEpithelialCells9.5
CD105+_Endothelial10
CD14+_Monocytes10.5
CD19+_BCells(neg._sel.)10.5
CD33+_Myeloid12.55
CD34+11.3
CD4+_Tcells9.3
CD56+_NKCells10.55
CD71+_EarlyErythroid9.7
CD8+_Tcells8.1
CardiacMyocytes19.55
Caudatenucleus34.4
Cerebellum8.5
CerebellumPeduncles12.9
CiliaryGanglion10.45
CingulateCortex16.65
Colorectaladenocarcinoma22.35
DorsalRootGanglion10.9
FetalThyroid11.35
Fetalbrain11.9
Fetalliver9.3
Fetallung7.8
GlobusPallidus13.6
Heart16.15
Hypothalamus10.75
Kidney9.25
Leukemia_chronicMyelogenousK-5629.1
Leukemia_promyelocytic-HL-608.8
Leukemialymphoblastic(MOLT-4)7.4
Liver17.65
Lung12.75
Lymphnode15.1
Lymphoma_burkitts(Daudi)13.4
Lymphoma_burkitts(Raji)17.6
MedullaOblongata60.95
OccipitalLobe64.3
OlfactoryBulb8.4
Ovary9.8
Pancreas8.6
PancreaticIslet11.75
ParietalLobe19.95
Pituitary11.9
Placenta9.5
Pons12.45
PrefrontalCortex42.4
Prostate12.3
Salivarygland8.75
SkeletalMuscle14.5
Skin15.25
SmoothMuscle11.85
Spinalcord11.75
SubthalamicNucleus17.5
SuperiorCervicalGanglion26.45
TemporalLobe29.25
Testis8.65
TestisGermCell8.1
TestisIntersitial8.55
TestisLeydigCell12.25
TestisSeminiferousTubule9.25
Thalamus11.35
Thymus17.6
Thyroid12.85
Tongue11
Tonsil11.05
Trachea18.05
TrigeminalGanglion18.85
Uterus8.5
UterusCorpus10.35
WholeBlood11
Wholebrain199.65
colon9.95
pineal_day29.86
pineal_night22.82
retina15.4
small_intestine9.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_11445_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.82 ± 0.71
Basal Forebrain3.95 ± 0.52
Basal Part of Pons4.01 ± 0.67
Cerebellar Cortex3.82 ± 0.65
Cerebellar Nuclei3.86 ± 0.6
Claustrum5.03 ± 0.55
Epithalamus3.29 ± 0.81
Frontal Lobe4.14 ± 0.61
Globus Pallidus3.74 ± 0.72
Hypothalamus3.75 ± 0.76
Insula4.09 ± 0.9
Limbic Lobe4.49 ± 0.71
Mesencephalon4.26 ± 0.77
Myelencephalon4.21 ± 0.69
Occipital Lobe4.51 ± 0.72
Parietal Lobe4.34 ± 0.69
Pontine Tegmentum4.12 ± 0.73
Striatum4.93 ± 0.42
Subthalamus3.68 ± 0.88
Temporal Lobe4.23 ± 0.64
Thalamus3.85 ± 0.65
White Matter2.83 ± 0.94
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Egr3CBCerebellum4.84
7.85
Egr3CTXCerebral cortex100
100
Egr3HIPHippocampal region62.51
100
Egr3HPFHippocampal formation65.56
100
Egr3HYHypothalamus9.41
10.41
Egr3LSXLateral septal complex68.13
66.61
Egr3MBMidbrain5.77
7.06
Egr3MYMedulla1.16
2.13
Egr3OLFOlfactory bulb73.05
93.09
Egr3PPons4.73
5.87
Egr3PALPallidum17.84
19.2
Egr3RHPRetrohippocampal region69.92
85.69
Egr3sAMYStriatum-like amygdalar nuclei24.25
24.23
Egr3STRStriatum89.42
89.2
Egr3STRdStriatum dorsal region100
100
Egr3STRvStriatum ventral region74.92
72.75
Egr3THThalamus9.8
17.28
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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