AutismKB 2.0

Annotation Detail for ADCY4


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Basic Information Top
Gene Symbol:ADCY4 ( AC4 )
Gene Full Name: adenylate cyclase 4
Band: 14q12
Quick LinksEntrez ID:196883; OMIM: 600292; Uniprot ID:ADCY4_HUMAN; ENSEMBL ID: ENSG00000129467; HGNC ID: 235
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus8 / 56401214
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult58 / 193912129
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor3 / 11424626
esophageal tumor1 / 1729057
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma2 / 10688318
head and neck tumor2 / 13630214
kidney tumor1 / 6895914
leukemia2 / 9584220
liver tumor2 / 9635920
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal66 / 336030719
ovarian tumor0 / 766820 
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone2 / 7165527
bone marrow0 / 488010 
brain5 / 11009894
cervix0 / 481710 
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus1 / 2020949
eye2 / 2110549
heart8 / 8962689
intestine5 / 23447221
kidney2 / 2117779
larynx0 / 241450 
liver3 / 20774314
lung4 / 33697411
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth2 / 6705229
muscle1 / 1077159
nerve1 / 1576863
ovary0 / 1020510 
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta20 / 28082571
prostate6 / 18934531
salivary gland0 / 201550 
skin0 / 2105740 
spleen2 / 5395237
stomach0 / 966190 
testis9 / 33044227
thymus2 / 8113124
thyroid2 / 4747342
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus9 / 23287838
vascular1 / 5178019
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7801_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.59 ± 0.86
Basal Forebrain2.1 ± 0.57
Basal Part of Pons2.27 ± 0.77
Cerebellar Cortex2.24 ± 0.66
Cerebellar Nuclei2.86 ± 0.57
Claustrum2.6 ± 0.6
Epithalamus2.19 ± 0.98
Frontal Lobe2.37 ± 0.66
Globus Pallidus3.02 ± 0.67
Hypothalamus2.59 ± 0.59
Insula2.36 ± 0.59
Limbic Lobe2.28 ± 0.65
Mesencephalon2.52 ± 0.77
Myelencephalon2.52 ± 0.57
Occipital Lobe2.65 ± 0.64
Parietal Lobe2.33 ± 0.66
Pontine Tegmentum2.41 ± 0.69
Striatum3.01 ± 0.63
Subthalamus2.96 ± 0.75
Temporal Lobe2.29 ± 0.69
Thalamus2.5 ± 0.62
White Matter2.36 ± 0.85
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Adcy4CBCerebellum12.21
17.14
Adcy4CTXCerebral cortex3.86
3.05
Adcy4HIPHippocampal region5.12
4.96
Adcy4HPFHippocampal formation5.56
5.05
Adcy4HYHypothalamus1.73
1.81
Adcy4LSXLateral septal complex0.26
0.19
Adcy4MBMidbrain2.49
3.16
Adcy4MYMedulla8.64
9.13
Adcy4OLFOlfactory bulb14.92
12.94
Adcy4PPons4.62
5.01
Adcy4PALPallidum4.08
4.17
Adcy4RHPRetrohippocampal region6.3
5.14
Adcy4sAMYStriatum-like amygdalar nuclei5.9
5.85
Adcy4STRStriatum4.74
4.05
Adcy4STRdStriatum dorsal region3.58
3.04
Adcy4STRvStriatum ventral region9.43
7.29
Adcy4THThalamus2.08
1.99
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018