Annotation Detail for MLKL
Basic Information Top
| Gene Symbol: | MLKL ( FLJ34389 ) |
|---|---|
| Gene Full Name: | mixed lineage kinase domain-like |
| Band: | 16q22.3 |
| Quick Links | Entrez ID:197259; OMIM: NA; Uniprot ID:MLKL_HUMAN; ENSEMBL ID: ENSG00000168404; HGNC ID: 26617 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.119878
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 0 / 70761 | 0 | |
| blastocyst | 0 / 62319 | 0 | |
| fetus | 5 / 564012 | 8 |  |
| neonate | 4 / 31097 | 128 |  |
| infant | 0 / 23620 | 0 | |
| juvenile | 2 / 55556 | 35 |  |
| adult | 30 / 1939121 | 15 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 3 / 94178 | 31 | |
| cervical tumor | 0 / 34366 | 0 | |
| chondrosarcoma | 3 / 82823 | 36 | |
| colorectal tumor | 2 / 114246 | 17 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 1 / 119369 | 8 | |
| germ cell tumor | 1 / 263845 | 3 | |
| glioma | 0 / 106883 | 0 | |
| head and neck tumor | 5 / 136302 | 36 | |
| kidney tumor | 2 / 68959 | 29 | |
| leukemia | 3 / 95842 | 31 | |
| liver tumor | 0 / 96359 | 0 | |
| lung tumor | 0 / 103127 | 0 | |
| lymphoma | 0 / 71755 | 0 | |
| non-neoplasia | 2 / 97250 | 20 | |
| normal | 49 / 3360307 | 14 | |
| ovarian tumor | 0 / 76682 | 0 | |
| pancreatic tumor | 0 / 104616 | 0 | |
| primitive neuroectodermal tumor of the CNS | 0 / 125680 | 0 | |
| prostate cancer | 1 / 102680 | 9 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 0 / 124949 | 0 | |
| soft tissue/muscle tissue tumor | 0 / 125191 | 0 | |
| uterine tumor | 2 / 90257 | 22 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 2 / 13106 | 152 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 1 / 40015 | 24 | |
| bladder | 0 / 29757 | 0 | |
| blood | 11 / 123478 | 89 | |
| bone | 2 / 71655 | 27 | |
| bone marrow | 1 / 48801 | 20 | |
| brain | 8 / 1100989 | 7 | |
| cervix | 5 / 48171 | 103 | |
| connective tissue | 5 / 149255 | 33 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 0 / 215722 | 0 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 1 / 211054 | 4 | |
| heart | 1 / 89626 | 11 | |
| intestine | 3 / 234472 | 12 | |
| kidney | 4 / 211777 | 18 | |
| larynx | 3 / 24145 | 124 | |
| liver | 1 / 207743 | 4 | |
| lung | 6 / 336974 | 17 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 1 / 91610 | 10 | |
| mammary gland | 4 / 153271 | 26 | |
| mouth | 1 / 67052 | 14 | |
| muscle | 1 / 107715 | 9 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 0 / 102051 | 0 | |
| pancreas | 4 / 214812 | 18 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 1 / 41328 | 24 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 1 / 280825 | 3 | |
| prostate | 2 / 189345 | 10 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 0 / 210574 | 0 | |
| spleen | 4 / 53952 | 74 | |
| stomach | 0 / 96619 | 0 | |
| testis | 0 / 330442 | 0 | |
| thymus | 4 / 81131 | 49 | |
| thyroid | 0 / 47473 | 0 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 4 / 52413 | 76 | |
| umbilical cord | 1 / 13680 | 73 | |
| uterus | 7 / 232878 | 30 | |
| vascular | 3 / 51780 | 57 | |
Microarray in - Probe name: A_23_P61050
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 3.11 ± 0.79 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 3.06 ± 0.37 | |
| Basal Part of Pons | 3.49 ± 0.46 | |
| Cerebellar Cortex | 2.83 ± 0.58 | |
| Cerebellar Nuclei | 4.51 ± 0.37 | |
| Claustrum | 2.93 ± 0.66 | |
| Epithalamus | 3.25 ± 0.6 | |
| Frontal Lobe | 3.33 ± 0.63 | |
| Globus Pallidus | 4.59 ± 0.38 | |
| Hypothalamus | 3.01 ± 0.66 | |
| Insula | 2.96 ± 0.64 | |
| Limbic Lobe | 3.01 ± 0.62 | |
| Mesencephalon | 3.45 ± 0.71 | |
| Myelencephalon | 3.36 ± 0.66 | |
| Occipital Lobe | 3.32 ± 0.81 | |
| Parietal Lobe | 3.26 ± 0.69 | |
| Pontine Tegmentum | 3.31 ± 0.69 | |
| Striatum | 4.02 ± 0.56 | |
| Subthalamus | 3.67 ± 0.49 | |
| Temporal Lobe | 3.21 ± 0.62 | |
| Thalamus | 3.57 ± 0.56 | |
| White Matter | 5.26 ± 0.5 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Mlkl | CB | Cerebellum | 0.16 | |
| 0.35 | | |||
| Mlkl | CTX | Cerebral cortex | 0.24 | |
| 0.28 | | |||
| Mlkl | HIP | Hippocampal region | 0.32 | |
| 0.3 | | |||
| Mlkl | HPF | Hippocampal formation | 0.23 | |
| 0.21 | | |||
| Mlkl | HY | Hypothalamus | 0.02 | |
| 0.04 | | |||
| Mlkl | LSX | Lateral septal complex | 0 | |
| 0 | | |||
| Mlkl | MB | Midbrain | 0.14 | |
| 0.21 | | |||
| Mlkl | MY | Medulla | 0.18 | |
| 0.24 | | |||
| Mlkl | OLF | Olfactory bulb | 0.05 | |
| 0.04 | | |||
| Mlkl | P | Pons | 0.29 | |
| 0.59 | | |||
| Mlkl | PAL | Pallidum | 0.02 | |
| 0.03 | | |||
| Mlkl | RHP | Retrohippocampal region | 0.08 | |
| 0.06 | | |||
| Mlkl | sAMY | Striatum-like amygdalar nuclei | 0.03 | |
| 0 | | |||
| Mlkl | STR | Striatum | 0.01 | |
| 0.01 | | |||
| Mlkl | STRd | Striatum dorsal region | 0.01 | |
| 0.01 | | |||
| Mlkl | STRv | Striatum ventral region | 0.02 | |
| 0.02 | | |||
| Mlkl | TH | Thalamus | 0.08 | |
| 0.1 | |