AutismKB 2.0

Annotation Detail for EIF4B


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Basic Information Top
Gene Symbol:EIF4B ( EIF-4B,PRO1843 )
Gene Full Name: eukaryotic translation initiation factor 4B
Band: 12q13.13
Quick LinksEntrez ID:1975; OMIM: 603928; Uniprot ID:IF4B_HUMAN; ENSEMBL ID: ENSG00000063046; HGNC ID: 3285
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body46 / 70761650
blastocyst81 / 623191299
fetus271 / 564012480
neonate30 / 31097964
infant15 / 23620635
juvenile63 / 555561133
adult916 / 1939121472
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor10 / 12794781
bladder carcinoma2 / 17475114
breast (mammary gland) tumor161 / 941781709
cervical tumor41 / 343661193
chondrosarcoma33 / 82823398
colorectal tumor48 / 114246420
esophageal tumor14 / 17290809
gastrointestinal tumor61 / 119369511
germ cell tumor229 / 263845867
glioma37 / 106883346
head and neck tumor98 / 136302718
kidney tumor24 / 68959348
leukemia76 / 95842792
liver tumor73 / 96359757
lung tumor56 / 103127543
lymphoma48 / 71755668
non-neoplasia43 / 97250442
normal1664 / 3360307495
ovarian tumor44 / 76682573
pancreatic tumor22 / 104616210
primitive neuroectodermal tumor of the CNS114 / 125680907
prostate cancer48 / 102680467
retinoblastoma38 / 46356819
skin tumor37 / 124949296
soft tissue/muscle tissue tumor46 / 125191367
uterine tumor35 / 90257387
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue7 / 13106534
adrenal gland23 / 33197692
ascites16 / 40015399
bladder24 / 29757806
blood80 / 123478647
bone36 / 71655502
bone marrow35 / 48801717
brain722 / 1100989655
cervix46 / 48171954
connective tissue73 / 149255489
ear9 / 16212555
embryonic tissue165 / 215722764
esophagus15 / 20209742
eye76 / 211054360
heart37 / 89626412
intestine105 / 234472447
kidney76 / 211777358
larynx36 / 241451490
liver98 / 207743471
lung131 / 336974388
lymph33 / 44270745
lymph node38 / 91610414
mammary gland182 / 1532711187
mouth47 / 67052700
muscle43 / 107715399
nerve8 / 15768507
ovary53 / 102051519
pancreas62 / 214812288
parathyroid4 / 20539194
pharynx8 / 41328193
pituitary gland9 / 16585542
placenta117 / 280825416
prostate71 / 189345374
salivary gland5 / 20155248
skin97 / 210574460
spleen31 / 53952574
stomach58 / 96619600
testis266 / 330442804
thymus121 / 811311491
thyroid26 / 47473547
tonsil5 / 16999294
trachea124 / 524132365
umbilical cord7 / 13680511
uterus174 / 232878747
vascular41 / 51780791
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211938_at
Cell line Expression level Expression bar
721_B_lymphoblasts1105.95
Adipocyte477
AdrenalCortex424.8
Adrenalgland303.65
Amygdala269.05
Appendix463.85
AtrioventricularNode276.15
BDCA4+_DentriticCells1112.75
Bonemarrow422.85
BronchialEpithelialCells643.05
CD105+_Endothelial730.6
CD14+_Monocytes831.35
CD19+_BCells(neg._sel.)1401.75
CD33+_Myeloid1021.15
CD34+1699.25
CD4+_Tcells1658.45
CD56+_NKCells1483.95
CD71+_EarlyErythroid252.85
CD8+_Tcells1459
CardiacMyocytes494.85
Caudatenucleus400.25
Cerebellum353.3
CerebellumPeduncles614.1
CiliaryGanglion234.1
CingulateCortex317.8
Colorectaladenocarcinoma356.65
DorsalRootGanglion265.95
FetalThyroid582.2
Fetalbrain717.25
Fetalliver379.2
Fetallung489
GlobusPallidus282.05
Heart253.95
Hypothalamus421.8
Kidney335.8
Leukemia_chronicMyelogenousK-562831.5
Leukemia_promyelocytic-HL-601244
Leukemialymphoblastic(MOLT-4)644.4
Liver260.15
Lung276.25
Lymphnode836.45
Lymphoma_burkitts(Daudi)2247.55
Lymphoma_burkitts(Raji)1114.85
MedullaOblongata303.05
OccipitalLobe302.75
OlfactoryBulb370.25
Ovary623.35
Pancreas543.6
PancreaticIslet803.2
ParietalLobe358.55
Pituitary861.25
Placenta511.75
Pons294.55
PrefrontalCortex612.55
Prostate401.4
Salivarygland777.5
SkeletalMuscle390.15
Skin332.75
SmoothMuscle811
Spinalcord393
SubthalamicNucleus301.55
SuperiorCervicalGanglion362
TemporalLobe216.4
Testis240.4
TestisGermCell299.2
TestisIntersitial270.85
TestisLeydigCell268.45
TestisSeminiferousTubule199.8
Thalamus289.05
Thymus558.55
Thyroid659.25
Tongue324.8
Tonsil566.4
Trachea499.55
TrigeminalGanglion238.85
Uterus524.25
UterusCorpus454.65
WholeBlood729.1
Wholebrain199.6
colon348.9
pineal_day580.6
pineal_night576.32
retina911.425
small_intestine711.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P60286
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.8 ± 0.19
Basal Forebrain7.94 ± 0.15
Basal Part of Pons8.06 ± 0.22
Cerebellar Cortex7.84 ± 0.21
Cerebellar Nuclei7.98 ± 0.15
Claustrum8.01 ± 0.23
Epithalamus7.85 ± 0.37
Frontal Lobe7.71 ± 0.24
Globus Pallidus8.34 ± 0.25
Hypothalamus7.72 ± 0.18
Insula7.65 ± 0.24
Limbic Lobe7.69 ± 0.24
Mesencephalon7.72 ± 0.31
Myelencephalon7.77 ± 0.28
Occipital Lobe7.68 ± 0.25
Parietal Lobe7.79 ± 0.26
Pontine Tegmentum7.75 ± 0.25
Striatum7.97 ± 0.37
Subthalamus7.77 ± 0.15
Temporal Lobe7.73 ± 0.22
Thalamus7.71 ± 0.24
White Matter8.48 ± 0.31
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
IF4B_HUMAN_2 8 2 9 AASAKKKN PRIDE
IF4B_HUMAN_272 7 272 278 SRIGSGR PRIDE
IF4B_HUMAN_329 11 329 339 PQRPKLNLKPR PRIDE
IF4B_HUMAN_357 16 357 372 AASIFGGAKPVDTAAR PRIDE
IF4B_HUMAN_420 16 420 435 TGSESSQTGTSTTSSR PRIDE
IF4B_HUMAN_92 25 92 116 SPPYTAFLGNLPYDVTEESIKEFFR PRIDE
PAp00007252 28 445 472 SLENETLNKEEDCHSPTSKPPKPDQPLK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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