AutismKB 2.0

Annotation Detail for EIF4E


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Basic Information Top
Gene Symbol:EIF4E ( CBP,EIF4E1,EIF4EL1,EIF4F,MGC111573 )
Gene Full Name: eukaryotic translation initiation factor 4E
Band: 4q23
Quick LinksEntrez ID:1977; OMIM: 133440; Uniprot ID:IF4E_HUMAN; ENSEMBL ID: ENSG00000151247; HGNC ID: 3287
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst2 / 6231932
fetus60 / 564012106
neonate6 / 31097192
infant11 / 23620465
juvenile16 / 55556287
adult187 / 193912196
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma13 / 17475743
breast (mammary gland) tumor3 / 9417831
cervical tumor4 / 34366116
chondrosarcoma8 / 8282396
colorectal tumor9 / 11424678
esophageal tumor3 / 17290173
gastrointestinal tumor26 / 119369217
germ cell tumor46 / 263845174
glioma9 / 10688384
head and neck tumor3 / 13630222
kidney tumor8 / 68959116
leukemia43 / 95842448
liver tumor9 / 9635993
lung tumor4 / 10312738
lymphoma9 / 71755125
non-neoplasia14 / 97250143
normal377 / 3360307112
ovarian tumor4 / 7668252
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS22 / 125680175
prostate cancer12 / 102680116
retinoblastoma6 / 46356129
skin tumor2 / 12494916
soft tissue/muscle tissue tumor18 / 125191143
uterine tumor10 / 90257110
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland4 / 33197120
ascites18 / 40015449
bladder14 / 29757470
blood14 / 123478113
bone5 / 7165569
bone marrow40 / 48801819
brain189 / 1100989171
cervix10 / 48171207
connective tissue13 / 14925587
ear1 / 1621261
embryonic tissue24 / 215722111
esophagus4 / 20209197
eye15 / 21105471
heart7 / 8962678
intestine22 / 23447293
kidney29 / 211777136
larynx0 / 241450 
liver19 / 20774391
lung31 / 33697491
lymph1 / 4427022
lymph node11 / 91610120
mammary gland14 / 15327191
mouth6 / 6705289
muscle10 / 10771592
nerve1 / 1576863
ovary6 / 10205158
pancreas10 / 21481246
parathyroid1 / 2053948
pharynx10 / 41328241
pituitary gland2 / 16585120
placenta13 / 28082546
prostate21 / 189345110
salivary gland5 / 20155248
skin7 / 21057433
spleen5 / 5395292
stomach9 / 9661993
testis69 / 330442208
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea5 / 5241395
umbilical cord2 / 13680146
uterus28 / 232878120
vascular14 / 51780270
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201436_at
Cell line Expression level Expression bar
721_B_lymphoblasts14.8
Adipocyte9.65
AdrenalCortex16.45
Adrenalgland9.25
Amygdala39.6
Appendix14.55
AtrioventricularNode14.8
BDCA4+_DentriticCells9.65
Bonemarrow13.25
BronchialEpithelialCells10.35
CD105+_Endothelial15.25
CD14+_Monocytes11.2
CD19+_BCells(neg._sel.)10.05
CD33+_Myeloid12.75
CD34+14.4
CD4+_Tcells9.75
CD56+_NKCells10.35
CD71+_EarlyErythroid11.75
CD8+_Tcells8.4
CardiacMyocytes22.9
Caudatenucleus10.15
Cerebellum9.4
CerebellumPeduncles17.6
CiliaryGanglion13.35
CingulateCortex22.9
Colorectaladenocarcinoma9.95
DorsalRootGanglion12.6
FetalThyroid11
Fetalbrain12.85
Fetalliver9.75
Fetallung7.75
GlobusPallidus16.85
Heart20.6
Hypothalamus30.05
Kidney10.25
Leukemia_chronicMyelogenousK-5629.9
Leukemia_promyelocytic-HL-6030.85
Leukemialymphoblastic(MOLT-4)8.45
Liver18.2
Lung10.85
Lymphnode8.05
Lymphoma_burkitts(Daudi)15.15
Lymphoma_burkitts(Raji)18.05
MedullaOblongata14.3
OccipitalLobe21.5
OlfactoryBulb7.95
Ovary9
Pancreas9.55
PancreaticIslet11.45
ParietalLobe17.45
Pituitary12.15
Placenta9.6
Pons11.7
PrefrontalCortex23.45
Prostate11.95
Salivarygland9.05
SkeletalMuscle20.5
Skin12.65
SmoothMuscle12.4
Spinalcord14.4
SubthalamicNucleus12.05
SuperiorCervicalGanglion24.2
TemporalLobe16.5
Testis8.5
TestisGermCell8.1
TestisIntersitial9.75
TestisLeydigCell11.45
TestisSeminiferousTubule8.5
Thalamus16.95
Thymus7
Thyroid16.75
Tongue13.85
Tonsil10.25
Trachea9.15
TrigeminalGanglion17.4
Uterus17.4
UterusCorpus11.7
WholeBlood11
Wholebrain20.85
colon13.05
pineal_day56.44
pineal_night34.94
retina19.725
small_intestine24.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P118643
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.66 ± 0.42
Basal Forebrain7.63 ± 0.28
Basal Part of Pons7.78 ± 0.27
Cerebellar Cortex7.73 ± 0.39
Cerebellar Nuclei7.67 ± 0.36
Claustrum7.49 ± 0.51
Epithalamus7.76 ± 0.27
Frontal Lobe7.9 ± 0.29
Globus Pallidus7.44 ± 0.23
Hypothalamus8.17 ± 0.11
Insula7.94 ± 0.3
Limbic Lobe7.55 ± 0.43
Mesencephalon7.73 ± 0.33
Myelencephalon7.65 ± 0.37
Occipital Lobe7.25 ± 0.41
Parietal Lobe7.74 ± 0.31
Pontine Tegmentum7.74 ± 0.4
Striatum7.36 ± 0.3
Subthalamus8.13 ± 0.17
Temporal Lobe7.8 ± 0.26
Thalamus7.63 ± 0.31
White Matter7.12 ± 0.31
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Eif4eCBCerebellum10.25
10.95
Eif4eCTXCerebral cortex24.13
16.9
Eif4eHIPHippocampal region18.73
19.64
Eif4eHPFHippocampal formation17.91
16.96
Eif4eHYHypothalamus3.17
2.63
Eif4eLSXLateral septal complex3.18
2.38
Eif4eMBMidbrain11.19
10.04
Eif4eMYMedulla11.69
12.87
Eif4eOLFOlfactory bulb17.66
13.97
Eif4ePPons9.59
10.54
Eif4ePALPallidum3.44
2.93
Eif4eRHPRetrohippocampal region17.02
13.58
Eif4esAMYStriatum-like amygdalar nuclei4.27
2.47
Eif4eSTRStriatum4.13
2.85
Eif4eSTRdStriatum dorsal region3.51
2.54
Eif4eSTRvStriatum ventral region6.33
4
Eif4eTHThalamus8.17
6.95
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
IF4E_HUMAN_162 11 162 172 IAIWTTECENR PRIDE
IF4E_HUMAN_192 14 192 205 IVIGYQSHADTATK PRIDE
IF4E_HUMAN_198 17 198 214 QSHADTATKSGSTTKNR PRIDE
IF4E_HUMAN_42 10 42 51 WALWFFKNDK PRIDE
IF4E_HUMAN_42 7 42 48 WALWFFK PRIDE
PAp00004113 14 213 226 IVIGYQSHADTATK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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