AutismKB 2.0

Annotation Detail for EIF4G1


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Basic Information Top
Gene Symbol:EIF4G1 ( DKFZp686A1451,EIF-4G1,EIF4F,EIF4G,EIF4GI,P220 )
Gene Full Name: eukaryotic translation initiation factor 4 gamma, 1
Band: 3q27.1
Quick LinksEntrez ID:1981; OMIM: 600495; Uniprot ID:IF4G1_HUMAN; ENSEMBL ID: ENSG00000114867; HGNC ID: 3296
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body35 / 70761494
blastocyst32 / 62319513
fetus76 / 564012134
neonate11 / 31097353
infant1 / 2362042
juvenile24 / 55556431
adult684 / 1939121352
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma4 / 17475228
breast (mammary gland) tumor140 / 941781486
cervical tumor20 / 34366581
chondrosarcoma30 / 82823362
colorectal tumor63 / 114246551
esophageal tumor2 / 17290115
gastrointestinal tumor60 / 119369502
germ cell tumor122 / 263845462
glioma35 / 106883327
head and neck tumor87 / 136302638
kidney tumor17 / 68959246
leukemia23 / 95842239
liver tumor30 / 96359311
lung tumor70 / 103127678
lymphoma33 / 71755459
non-neoplasia17 / 97250174
normal586 / 3360307174
ovarian tumor20 / 76682260
pancreatic tumor48 / 104616458
primitive neuroectodermal tumor of the CNS40 / 125680318
prostate cancer59 / 102680574
retinoblastoma16 / 46356345
skin tumor127 / 1249491016
soft tissue/muscle tissue tumor36 / 125191287
uterine tumor23 / 90257254
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue7 / 13106534
adrenal gland5 / 33197150
ascites40 / 40015999
bladder10 / 29757336
blood21 / 123478170
bone29 / 71655404
bone marrow4 / 4880181
brain184 / 1100989167
cervix29 / 48171602
connective tissue31 / 149255207
ear0 / 162120 
embryonic tissue80 / 215722370
esophagus2 / 2020998
eye72 / 211054341
heart8 / 8962689
intestine91 / 234472388
kidney43 / 211777203
larynx19 / 24145786
liver34 / 207743163
lung134 / 336974397
lymph26 / 44270587
lymph node26 / 91610283
mammary gland157 / 1532711024
mouth49 / 67052730
muscle28 / 107715259
nerve5 / 15768317
ovary31 / 102051303
pancreas54 / 214812251
parathyroid3 / 20539146
pharynx3 / 4132872
pituitary gland0 / 165850 
placenta73 / 280825259
prostate80 / 189345422
salivary gland8 / 20155396
skin145 / 210574688
spleen7 / 53952129
stomach16 / 96619165
testis103 / 330442311
thymus10 / 81131123
thyroid17 / 47473358
tonsil4 / 16999235
trachea6 / 52413114
umbilical cord3 / 13680219
uterus62 / 232878266
vascular7 / 51780135
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208625_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts837.7
Adipocyte302.5
AdrenalCortex265.05
Adrenalgland196.75
Amygdala251.7
Appendix49.3
AtrioventricularNode37.75
BDCA4+_DentriticCells418.6
Bonemarrow201.5
BronchialEpithelialCells391.1
CD105+_Endothelial451.1
CD14+_Monocytes242.35
CD19+_BCells(neg._sel.)154.65
CD33+_Myeloid358.95
CD34+385.8
CD4+_Tcells328.55
CD56+_NKCells239.95
CD71+_EarlyErythroid497.75
CD8+_Tcells312.45
CardiacMyocytes451.95
Caudatenucleus86.55
Cerebellum138.6
CerebellumPeduncles177.65
CiliaryGanglion27.25
CingulateCortex118.1
Colorectaladenocarcinoma946.7
DorsalRootGanglion66.6
FetalThyroid256.65
Fetalbrain148.55
Fetalliver201.4
Fetallung253.35
GlobusPallidus59.6
Heart334.9
Hypothalamus243.15
Kidney138.75
Leukemia_chronicMyelogenousK-562168.5
Leukemia_promyelocytic-HL-60302.45
Leukemialymphoblastic(MOLT-4)236.6
Liver847.45
Lung833.1
Lymphnode175.8
Lymphoma_burkitts(Daudi)283.65
Lymphoma_burkitts(Raji)847.35
MedullaOblongata94.75
OccipitalLobe139.75
OlfactoryBulb152.8
Ovary75.9
Pancreas201.1
PancreaticIslet221.6
ParietalLobe102
Pituitary182.55
Placenta401.8
Pons110.45
PrefrontalCortex309.9
Prostate1185
Salivarygland33.45
SkeletalMuscle239.35
Skin22.75
SmoothMuscle670.45
Spinalcord186.4
SubthalamicNucleus122.25
SuperiorCervicalGanglion38.9
TemporalLobe83.35
Testis238.6
TestisGermCell331.05
TestisIntersitial209.15
TestisLeydigCell151.45
TestisSeminiferousTubule171.15
Thalamus120.85
Thymus245.75
Thyroid846.75
Tongue168.95
Tonsil194.55
Trachea172.4
TrigeminalGanglion39.15
Uterus301.7
UterusCorpus64.55
WholeBlood186.2
Wholebrain203.4
colon308.4
pineal_day318.04
pineal_night290.6
retina455.225
small_intestine280.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15229_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.06 ± 0.29
Basal Forebrain5.82 ± 0.34
Basal Part of Pons5.85 ± 0.4
Cerebellar Cortex5.89 ± 0.45
Cerebellar Nuclei5.8 ± 0.38
Claustrum6.17 ± 0.3
Epithalamus5.66 ± 0.39
Frontal Lobe5.95 ± 0.36
Globus Pallidus6.23 ± 0.24
Hypothalamus5.98 ± 0.35
Insula5.84 ± 0.21
Limbic Lobe6 ± 0.43
Mesencephalon5.84 ± 0.46
Myelencephalon5.9 ± 0.43
Occipital Lobe5.63 ± 0.38
Parietal Lobe5.96 ± 0.39
Pontine Tegmentum5.91 ± 0.35
Striatum5.65 ± 0.33
Subthalamus5.71 ± 0.43
Temporal Lobe6.01 ± 0.34
Thalamus5.93 ± 0.36
White Matter5.88 ± 0.75
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Eif4g1CBCerebellum100
100
Eif4g1CTXCerebral cortex100
100
Eif4g1HIPHippocampal region100
100
Eif4g1HPFHippocampal formation100
100
Eif4g1HYHypothalamus100
100
Eif4g1LSXLateral septal complex100
100
Eif4g1MBMidbrain100
100
Eif4g1MYMedulla100
100
Eif4g1OLFOlfactory bulb100
100
Eif4g1PPons86.09
100
Eif4g1PALPallidum100
100
Eif4g1RHPRetrohippocampal region100
100
Eif4g1sAMYStriatum-like amygdalar nuclei100
100
Eif4g1STRStriatum100
100
Eif4g1STRdStriatum dorsal region100
100
Eif4g1STRvStriatum ventral region100
100
Eif4g1THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
IF4G1_HUMAN_1009 8 1009 1016 EAEMEEHR PRIDE
IF4G1_HUMAN_1043 17 1043 1059 GLPLVDDGGWNTVPISK PRIDE
IF4G1_HUMAN_1096 27 1096 1122 GSSGGSGAKPSDAASEAARPATSTLNR PRIDE
IF4G1_HUMAN_1261 20 1261 1280 EAVQCVQELASPSLLFIFVR PRIDE
IF4G1_HUMAN_1372 14 1372 1385 AASLLLEILGLLCK PRIDE
IF4G1_HUMAN_1447 14 1447 1460 QLEKLLKEGSSNQR PRIDE
IF4G1_HUMAN_191 11 191 201 DITEEIMSGAR PRIDE
IF4G1_HUMAN_716 12 716 727 IIATVLMTEDIK PRIDE
IF4G1_HUMAN_74 15 74 88 PGPAAHVYPAGSQVM PRIDE
IF4G1_HUMAN_868 11 868 878 EMDEAATAEER PRIDE
IF4G1_HUMAN_977 10 977 986 FMLQDVLDLR PRIDE
PAp00001299 17 847 863 CQKEFEKDKDDDEVFEK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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