AutismKB 2.0

Annotation Detail for EIF5


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Basic Information Top
Gene Symbol:EIF5 ( EIF-5A )
Gene Full Name: eukaryotic translation initiation factor 5
Band: 14q32.32
Quick LinksEntrez ID:1983; OMIM: 601710; Uniprot ID:IF5_HUMAN; ENSEMBL ID: ENSG00000100664; HGNC ID: 3299
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body16 / 70761226
blastocyst19 / 62319304
fetus187 / 564012331
neonate6 / 31097192
infant8 / 23620338
juvenile22 / 55556395
adult394 / 1939121203
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor4 / 12794312
bladder carcinoma2 / 17475114
breast (mammary gland) tumor14 / 94178148
cervical tumor20 / 34366581
chondrosarcoma22 / 82823265
colorectal tumor29 / 114246253
esophageal tumor8 / 17290462
gastrointestinal tumor29 / 119369242
germ cell tumor66 / 263845250
glioma18 / 106883168
head and neck tumor41 / 136302300
kidney tumor16 / 68959232
leukemia17 / 95842177
liver tumor24 / 96359249
lung tumor17 / 103127164
lymphoma16 / 71755222
non-neoplasia28 / 97250287
normal1003 / 3360307298
ovarian tumor7 / 7668291
pancreatic tumor22 / 104616210
primitive neuroectodermal tumor of the CNS21 / 125680167
prostate cancer15 / 102680146
retinoblastoma3 / 4635664
skin tumor22 / 124949176
soft tissue/muscle tissue tumor18 / 125191143
uterine tumor24 / 90257265
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland7 / 33197210
ascites11 / 40015274
bladder7 / 29757235
blood21 / 123478170
bone25 / 71655348
bone marrow11 / 48801225
brain363 / 1100989329
cervix20 / 48171415
connective tissue29 / 149255194
ear2 / 16212123
embryonic tissue54 / 215722250
esophagus8 / 20209395
eye32 / 211054151
heart38 / 89626423
intestine55 / 234472234
kidney42 / 211777198
larynx5 / 24145207
liver72 / 207743346
lung80 / 336974237
lymph9 / 44270203
lymph node42 / 91610458
mammary gland22 / 153271143
mouth30 / 67052447
muscle22 / 107715204
nerve1 / 1576863
ovary9 / 10205188
pancreas47 / 214812218
parathyroid10 / 20539486
pharynx0 / 413280 
pituitary gland3 / 16585180
placenta68 / 280825242
prostate22 / 189345116
salivary gland2 / 2015599
skin78 / 210574370
spleen6 / 53952111
stomach46 / 96619476
testis178 / 330442538
thymus13 / 81131160
thyroid11 / 47473231
tonsil0 / 169990 
trachea17 / 52413324
umbilical cord2 / 13680146
uterus88 / 232878377
vascular9 / 51780173
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208290_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts209.9
Adipocyte30.35
AdrenalCortex13.5
Adrenalgland8.7
Amygdala88.25
Appendix8.5
AtrioventricularNode10.35
BDCA4+_DentriticCells108.25
Bonemarrow17.3
BronchialEpithelialCells44.8
CD105+_Endothelial35.7
CD14+_Monocytes70.8
CD19+_BCells(neg._sel.)49.45
CD33+_Myeloid70.7
CD34+21.6
CD4+_Tcells71.9
CD56+_NKCells25.95
CD71+_EarlyErythroid410.4
CD8+_Tcells43.65
CardiacMyocytes93.25
Caudatenucleus31.9
Cerebellum11.8
CerebellumPeduncles10.95
CiliaryGanglion9.85
CingulateCortex32.3
Colorectaladenocarcinoma39.8
DorsalRootGanglion9.3
FetalThyroid18.35
Fetalbrain15.1
Fetalliver61.1
Fetallung61.6
GlobusPallidus12
Heart14.05
Hypothalamus42.85
Kidney7.15
Leukemia_chronicMyelogenousK-56239.35
Leukemia_promyelocytic-HL-6021.75
Leukemialymphoblastic(MOLT-4)21.8
Liver17.3
Lung8.65
Lymphnode12.45
Lymphoma_burkitts(Daudi)23.35
Lymphoma_burkitts(Raji)18.35
MedullaOblongata22.75
OccipitalLobe52.85
OlfactoryBulb13.05
Ovary9.6
Pancreas14.95
PancreaticIslet18.15
ParietalLobe23.3
Pituitary18.3
Placenta53.3
Pons14.8
PrefrontalCortex42.15
Prostate12.35
Salivarygland11.7
SkeletalMuscle10.35
Skin10.2
SmoothMuscle93.95
Spinalcord22.5
SubthalamicNucleus13.45
SuperiorCervicalGanglion10.3
TemporalLobe26.6
Testis42.2
TestisGermCell123.05
TestisIntersitial163.45
TestisLeydigCell103.35
TestisSeminiferousTubule34.8
Thalamus28.15
Thymus11.35
Thyroid39.1
Tongue12.85
Tonsil20.55
Trachea12.85
TrigeminalGanglion8.6
Uterus13.25
UterusCorpus13.15
WholeBlood36.85
Wholebrain29.8
colon47
pineal_day31.04
pineal_night55
retina23.175
small_intestine18.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P205265
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala10.04 ± 0.21
Basal Forebrain9.94 ± 0.14
Basal Part of Pons10.01 ± 0.17
Cerebellar Cortex9.79 ± 0.19
Cerebellar Nuclei10 ± 0.24
Claustrum10.08 ± 0.18
Epithalamus9.89 ± 0.18
Frontal Lobe10.08 ± 0.2
Globus Pallidus9.95 ± 0.17
Hypothalamus10.09 ± 0.2
Insula10.02 ± 0.15
Limbic Lobe9.95 ± 0.26
Mesencephalon10.02 ± 0.28
Myelencephalon9.97 ± 0.23
Occipital Lobe9.72 ± 0.29
Parietal Lobe10.04 ± 0.25
Pontine Tegmentum10 ± 0.21
Striatum9.93 ± 0.27
Subthalamus10.18 ± 0.19
Temporal Lobe10.04 ± 0.19
Thalamus9.86 ± 0.21
White Matter10.1 ± 0.14
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Eif5CBCerebellum24.46
42.74
Eif5CTXCerebral cortex9.8
7.5
Eif5HIPHippocampal region41.91
23.83
Eif5HPFHippocampal formation32.63
18.82
Eif5HYHypothalamus23.88
16.3
Eif5LSXLateral septal complex4.04
2.42
Eif5MBMidbrain16.68
14.46
Eif5MYMedulla45.49
47.63
Eif5OLFOlfactory bulb28.98
18.65
Eif5PPons36.34
37.05
Eif5PALPallidum9.96
9.08
Eif5RHPRetrohippocampal region16.88
11.51
Eif5sAMYStriatum-like amygdalar nuclei12.04
7.37
Eif5STRStriatum5.54
3.63
Eif5STRdStriatum dorsal region2.41
1.74
Eif5STRvStriatum ventral region12.68
7.65
Eif5THThalamus6.86
4.6
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
IF5_HUMAN_129 8 129 136 GMLDTHHK PRIDE
IF5_HUMAN_224 10 224 233 VLTLSDDLER PRIDE
IF5_HUMAN_239 9 239 247 VNILFDFVK PRIDE
IF5_HUMAN_273 15 273 287 AMGPLVLTEVLFNEK PRIDE
IF5_HUMAN_312 20 312 331 YLLHGLECVVAMHQAQLISK PRIDE
IF5_HUMAN_33 11 33 43 TVIVNMVDVAK PRIDE
IF5_HUMAN_8 8 8 15 SVSDQFYR PRIDE
IF5_HUMAN_85 10 85 94 LQDMLDGFIK PRIDE
IF5_HUMAN_95 19 95 113 FVLCPECENPETDLHVNPK PRIDE
PAp00000546 26 45 70 ALNRPPTYPTKYFGCELGAQTQFDVK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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