AutismKB 2.0

Annotation Detail for AIF1


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Basic Information Top
Gene Symbol:AIF1 ( AIF-1,IBA1,IRT-1,IRT1 )
Gene Full Name: allograft inflammatory factor 1
Band: 6p21.33
Quick LinksEntrez ID:199; OMIM: 601833; Uniprot ID:AIF1_HUMAN; ENSEMBL ID: ENSG00000204472; HGNC ID: 352
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus32 / 56401256
neonate0 / 310970 
infant1 / 2362042
juvenile0 / 555560 
adult113 / 193912158
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor4 / 12794312
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor5 / 11936941
germ cell tumor1 / 2638453
glioma14 / 106883130
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia9 / 9584293
liver tumor2 / 9635920
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal152 / 336030745
ovarian tumor2 / 7668226
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer3 / 10268029
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland5 / 33197150
ascites0 / 400150 
bladder0 / 297570 
blood19 / 123478153
bone0 / 716550 
bone marrow5 / 48801102
brain24 / 110098921
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye4 / 21105418
heart15 / 89626167
intestine3 / 23447212
kidney11 / 21177751
larynx0 / 241450 
liver5 / 20774324
lung11 / 33697432
lymph0 / 442700 
lymph node8 / 9161087
mammary gland3 / 15327119
mouth0 / 670520 
muscle4 / 10771537
nerve0 / 157680 
ovary5 / 10205148
pancreas1 / 2148124
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta14 / 28082549
prostate7 / 18934536
salivary gland0 / 201550 
skin1 / 2105744
spleen1 / 5395218
stomach2 / 9661920
testis3 / 3304429
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus11 / 23287847
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209901_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts31.75
Adipocyte20.9
AdrenalCortex23.05
Adrenalgland31.55
Amygdala21.6
Appendix22.6
AtrioventricularNode17.1
BDCA4+_DentriticCells1044.3
Bonemarrow275.6
BronchialEpithelialCells17
CD105+_Endothelial97
CD14+_Monocytes4391.3
CD19+_BCells(neg._sel.)22.8
CD33+_Myeloid3604.75
CD34+86.6
CD4+_Tcells24.75
CD56+_NKCells1222.65
CD71+_EarlyErythroid18.55
CD8+_Tcells21.95
CardiacMyocytes18.75
Caudatenucleus39.4
Cerebellum21.55
CerebellumPeduncles25.5
CiliaryGanglion17.7
CingulateCortex23.15
Colorectaladenocarcinoma20.75
DorsalRootGanglion31.15
FetalThyroid20.9
Fetalbrain22.6
Fetalliver24.35
Fetallung26.65
GlobusPallidus16.65
Heart28.15
Hypothalamus38.65
Kidney28
Leukemia_chronicMyelogenousK-56220.65
Leukemia_promyelocytic-HL-6018.3
Leukemialymphoblastic(MOLT-4)34.65
Liver30.1
Lung34.95
Lymphnode76.25
Lymphoma_burkitts(Daudi)26.65
Lymphoma_burkitts(Raji)23.85
MedullaOblongata22.65
OccipitalLobe20.55
OlfactoryBulb35.3
Ovary15.35
Pancreas18.2
PancreaticIslet24.1
ParietalLobe27.75
Pituitary26.7
Placenta54.1
Pons21.95
PrefrontalCortex25.4
Prostate22.9
Salivarygland18.25
SkeletalMuscle43.55
Skin16.65
SmoothMuscle16.8
Spinalcord85.95
SubthalamicNucleus20.15
SuperiorCervicalGanglion30.75
TemporalLobe22.15
Testis19.45
TestisGermCell17.7
TestisIntersitial18.1
TestisLeydigCell20.7
TestisSeminiferousTubule19.6
Thalamus25.55
Thymus36.6
Thyroid22.35
Tongue21.75
Tonsil35
Trachea22.55
TrigeminalGanglion22.25
Uterus16.85
UterusCorpus23.5
WholeBlood3519.65
Wholebrain19.4
colon21.6
pineal_day27.04
pineal_night24.78
retina34.625
small_intestine22.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_13531_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.92 ± 0.89
Basal Forebrain2.4 ± 0.68
Basal Part of Pons3.38 ± 0.68
Cerebellar Cortex2.08 ± 0.61
Cerebellar Nuclei3.74 ± 0.49
Claustrum2.7 ± 0.7
Epithalamus3.97 ± 0.66
Frontal Lobe2.62 ± 0.89
Globus Pallidus4.47 ± 0.64
Hypothalamus2.72 ± 1.33
Insula2.88 ± 0.63
Limbic Lobe2.46 ± 0.74
Mesencephalon2.72 ± 0.81
Myelencephalon2.66 ± 0.83
Occipital Lobe2.17 ± 0.81
Parietal Lobe2.48 ± 0.81
Pontine Tegmentum2.53 ± 0.82
Striatum3.04 ± 0.71
Subthalamus3.11 ± 0.49
Temporal Lobe2.82 ± 0.74
Thalamus2.55 ± 0.69
White Matter4.21 ± 0.54
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Aif1CBCerebellum0.73
1.13
Aif1CTXCerebral cortex0.57
0.62
Aif1HIPHippocampal region0.47
0.5
Aif1HPFHippocampal formation0.48
0.44
Aif1HYHypothalamus0.17
0.14
Aif1LSXLateral septal complex0.3
0.38
Aif1MBMidbrain0.45
0.76
Aif1MYMedulla1.7
2.17
Aif1OLFOlfactory bulb1.26
1.56
Aif1PPons0.51
0.64
Aif1PALPallidum0.1
0.1
Aif1RHPRetrohippocampal region0.45
0.35
Aif1sAMYStriatum-like amygdalar nuclei0.18
0.24
Aif1STRStriatum0.3
0.36
Aif1STRdStriatum dorsal region0.26
0.32
Aif1STRvStriatum ventral region0.41
0.42
Aif1THThalamus0.36
0.49
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00039234 15 51 65 YSSDEDLPSKLEGFK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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