AutismKB 2.0

Annotation Detail for SPRED2


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Basic Information Top
Gene Symbol:SPRED2 ( FLJ21897,FLJ31917,MGC163164,Spred-2 )
Gene Full Name: sprouty-related, EVH1 domain containing 2
Band: 2p14
Quick LinksEntrez ID:200734; OMIM: 609292; Uniprot ID:SPRE2_HUMAN; ENSEMBL ID: ENSG00000198369; HGNC ID: 17722
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst9 / 62319144
fetus28 / 56401249
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult101 / 193912152
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor3 / 3436687
chondrosarcoma3 / 8282336
colorectal tumor8 / 11424670
esophageal tumor1 / 1729057
gastrointestinal tumor14 / 119369117
germ cell tumor21 / 26384579
glioma8 / 10688374
head and neck tumor10 / 13630273
kidney tumor1 / 6895914
leukemia3 / 9584231
liver tumor4 / 9635941
lung tumor2 / 10312719
lymphoma4 / 7175555
non-neoplasia2 / 9725020
normal215 / 336030763
ovarian tumor4 / 7668252
pancreatic tumor10 / 10461695
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer3 / 10268029
retinoblastoma3 / 4635664
skin tumor8 / 12494964
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder1 / 2975733
blood4 / 12347832
bone1 / 7165513
bone marrow0 / 488010 
brain81 / 110098973
cervix3 / 4817162
connective tissue4 / 14925526
ear2 / 16212123
embryonic tissue14 / 21572264
esophagus1 / 2020949
eye12 / 21105456
heart0 / 896260 
intestine11 / 23447246
kidney8 / 21177737
larynx2 / 2414582
liver4 / 20774319
lung10 / 33697429
lymph0 / 442700 
lymph node55 / 91610600
mammary gland2 / 15327113
mouth7 / 67052104
muscle2 / 10771518
nerve1 / 1576863
ovary5 / 10205148
pancreas13 / 21481260
parathyroid3 / 20539146
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta4 / 28082514
prostate9 / 18934547
salivary gland0 / 201550 
skin18 / 21057485
spleen1 / 5395218
stomach12 / 96619124
testis12 / 33044236
thymus5 / 8113161
thyroid1 / 4747321
tonsil0 / 169990 
trachea6 / 52413114
umbilical cord0 / 136800 
uterus11 / 23287847
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212466_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.3
Adipocyte4.25
AdrenalCortex4.5
Adrenalgland3.6
Amygdala4.45
Appendix4.25
AtrioventricularNode3.3
BDCA4+_DentriticCells4.65
Bonemarrow4.15
BronchialEpithelialCells4.2
CD105+_Endothelial4.35
CD14+_Monocytes4.9
CD19+_BCells(neg._sel.)4.55
CD33+_Myeloid5.85
CD34+5.65
CD4+_Tcells4.65
CD56+_NKCells5.7
CD71+_EarlyErythroid4
CD8+_Tcells4
CardiacMyocytes6
Caudatenucleus3.8
Cerebellum3.45
CerebellumPeduncles5
CiliaryGanglion3.2
CingulateCortex4.45
Colorectaladenocarcinoma4.4
DorsalRootGanglion3.25
FetalThyroid4.05
Fetalbrain4.15
Fetalliver3.65
Fetallung3.4
GlobusPallidus3.2
Heart5.8
Hypothalamus4.55
Kidney3.4
Leukemia_chronicMyelogenousK-5624
Leukemia_promyelocytic-HL-603.75
Leukemialymphoblastic(MOLT-4)3.4
Liver5.6
Lung4.65
Lymphnode3.6
Lymphoma_burkitts(Daudi)5.4
Lymphoma_burkitts(Raji)6.05
MedullaOblongata3.9
OccipitalLobe3.8
OlfactoryBulb3.35
Ovary2.8
Pancreas3.4
PancreaticIslet4.55
ParietalLobe4.5
Pituitary4.95
Placenta4.35
Pons7.5
PrefrontalCortex5.35
Prostate4.95
Salivarygland3.45
SkeletalMuscle5.2
Skin3.4
SmoothMuscle4.8
Spinalcord4.55
SubthalamicNucleus4.45
SuperiorCervicalGanglion5.2
TemporalLobe8.8
Testis3.6
TestisGermCell3.55
TestisIntersitial3.55
TestisLeydigCell4.35
TestisSeminiferousTubule3.6
Thalamus4.35
Thymus3.35
Thyroid5.3
Tongue4.1
Tonsil4.2
Trachea3.55
TrigeminalGanglion4.4
Uterus3.5
UterusCorpus3.9
WholeBlood4.65
Wholebrain3.6
colon4.25
pineal_day5.28
pineal_night5.16
retina5.175
small_intestine4.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P225854
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.89 ± 0.38
Basal Forebrain4.55 ± 0.25
Basal Part of Pons4.53 ± 0.33
Cerebellar Cortex4.78 ± 0.39
Cerebellar Nuclei4.38 ± 0.43
Claustrum5.01 ± 0.45
Epithalamus4.46 ± 0.35
Frontal Lobe4.71 ± 0.48
Globus Pallidus3.86 ± 0.3
Hypothalamus4.28 ± 0.63
Insula4.86 ± 0.33
Limbic Lobe4.69 ± 0.51
Mesencephalon4.79 ± 0.6
Myelencephalon4.64 ± 0.5
Occipital Lobe4.97 ± 0.49
Parietal Lobe4.78 ± 0.43
Pontine Tegmentum4.75 ± 0.56
Striatum4.06 ± 0.55
Subthalamus4.48 ± 0.03
Temporal Lobe4.77 ± 0.45
Thalamus4.68 ± 0.48
White Matter2.97 ± 0.19
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Spred2CBCerebellum5.16
6.33
Spred2CTXCerebral cortex16.75
11.81
Spred2HIPHippocampal region14.33
16.47
Spred2HPFHippocampal formation12.42
12.18
Spred2HYHypothalamus0.32
0.21
Spred2LSXLateral septal complex0.21
0.17
Spred2MBMidbrain1.27
1.36
Spred2MYMedulla4.43
4.3
Spred2OLFOlfactory bulb9.15
6.95
Spred2PPons2.93
3.11
Spred2PALPallidum0.37
0.27
Spred2RHPRetrohippocampal region10.11
7.42
Spred2sAMYStriatum-like amygdalar nuclei0.52
0.45
Spred2STRStriatum1.03
0.83
Spred2STRdStriatum dorsal region1.24
1.08
Spred2STRvStriatum ventral region0.77
0.43
Spred2THThalamus0.72
0.72
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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