AutismKB 2.0

Annotation Detail for LGI3


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Basic Information Top
Gene Symbol:LGI3 ( LGIL4 )
Gene Full Name: leucine-rich repeat LGI family, member 3
Band: 8p21.3
Quick LinksEntrez ID:203190; OMIM: 608302; Uniprot ID:LGI3_HUMAN; ENSEMBL ID: ENSG00000168481; HGNC ID: 18711
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus0 / 5640120 
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult25 / 193912112
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma2 / 10688318
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal30 / 33603078
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor7 / 12494956
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain35 / 110098931
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine1 / 2344724
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung1 / 3369742
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve1 / 1576863
ovary0 / 1020510 
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate2 / 18934510
salivary gland0 / 201550 
skin7 / 21057433
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_6241_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.64 ± 0.67
Basal Forebrain5.09 ± 0.46
Basal Part of Pons5.56 ± 0.55
Cerebellar Cortex4.11 ± 0.7
Cerebellar Nuclei6.34 ± 0.36
Claustrum5.47 ± 0.91
Epithalamus3.95 ± 1.02
Frontal Lobe4.86 ± 0.86
Globus Pallidus6.02 ± 0.28
Hypothalamus4.59 ± 0.52
Insula4.35 ± 0.69
Limbic Lobe4.48 ± 0.92
Mesencephalon5.26 ± 0.87
Myelencephalon5.1 ± 0.76
Occipital Lobe5.72 ± 0.61
Parietal Lobe5.31 ± 0.6
Pontine Tegmentum5.06 ± 0.72
Striatum5.71 ± 0.51
Subthalamus5.3 ± 0.73
Temporal Lobe4.59 ± 0.82
Thalamus5.44 ± 0.7
White Matter6.81 ± 0.6
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Lgi3CBCerebellum48.91
63.97
Lgi3CTXCerebral cortex56.99
52.02
Lgi3HIPHippocampal region43.68
65.49
Lgi3HPFHippocampal formation40.71
50.26
Lgi3HYHypothalamus43.58
41.02
Lgi3LSXLateral septal complex33.8
25.97
Lgi3MBMidbrain71.76
76.8
Lgi3MYMedulla74.47
94.37
Lgi3OLFOlfactory bulb44.38
40.06
Lgi3PPons69.29
85.05
Lgi3PALPallidum47.16
51.37
Lgi3RHPRetrohippocampal region36.59
31.69
Lgi3sAMYStriatum-like amygdalar nuclei25.65
22.03
Lgi3STRStriatum29.93
24.14
Lgi3STRdStriatum dorsal region32.72
26.46
Lgi3STRvStriatum ventral region23.07
18.27
Lgi3THThalamus74.74
76.79
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018