AutismKB 2.0

Annotation Detail for AK2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:AK2 ( ADK2 )
Gene Full Name: adenylate kinase 2
Band: 1p35.1
Quick LinksEntrez ID:204; OMIM: 103020; Uniprot ID:KAD2_HUMAN; ENSEMBL ID: ENSG00000004455; HGNC ID: 362
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body9 / 70761127
blastocyst24 / 62319385
fetus74 / 564012131
neonate5 / 31097160
infant7 / 23620296
juvenile17 / 55556305
adult329 / 1939121169
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma1 / 1747557
breast (mammary gland) tumor20 / 94178212
cervical tumor15 / 34366436
chondrosarcoma14 / 82823169
colorectal tumor22 / 114246192
esophageal tumor2 / 17290115
gastrointestinal tumor37 / 119369309
germ cell tumor54 / 263845204
glioma12 / 106883112
head and neck tumor18 / 136302132
kidney tumor5 / 6895972
leukemia23 / 95842239
liver tumor12 / 96359124
lung tumor21 / 103127203
lymphoma29 / 71755404
non-neoplasia15 / 97250154
normal503 / 3360307149
ovarian tumor19 / 76682247
pancreatic tumor16 / 104616152
primitive neuroectodermal tumor of the CNS25 / 125680198
prostate cancer11 / 102680107
retinoblastoma8 / 46356172
skin tumor32 / 124949256
soft tissue/muscle tissue tumor27 / 125191215
uterine tumor15 / 90257166
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland5 / 33197150
ascites19 / 40015474
bladder5 / 29757168
blood24 / 123478194
bone14 / 71655195
bone marrow11 / 48801225
brain97 / 110098988
cervix21 / 48171435
connective tissue18 / 149255120
ear0 / 162120 
embryonic tissue43 / 215722199
esophagus2 / 2020998
eye45 / 211054213
heart21 / 89626234
intestine42 / 234472179
kidney48 / 211777226
larynx0 / 241450 
liver25 / 207743120
lung62 / 336974183
lymph25 / 44270564
lymph node17 / 91610185
mammary gland28 / 153271182
mouth5 / 6705274
muscle17 / 107715157
nerve2 / 15768126
ovary23 / 102051225
pancreas36 / 214812167
parathyroid12 / 20539584
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta44 / 280825156
prostate26 / 189345137
salivary gland2 / 2015599
skin59 / 210574280
spleen9 / 53952166
stomach14 / 96619144
testis38 / 330442114
thymus14 / 81131172
thyroid12 / 47473252
tonsil0 / 169990 
trachea9 / 52413171
umbilical cord1 / 1368073
uterus50 / 232878214
vascular7 / 51780135
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212175_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts871.2
Adipocyte15.7
AdrenalCortex12.15
Adrenalgland25.35
Amygdala12.7
Appendix19.95
AtrioventricularNode9.4
BDCA4+_DentriticCells116.15
Bonemarrow54.55
BronchialEpithelialCells146.95
CD105+_Endothelial88.25
CD14+_Monocytes52.9
CD19+_BCells(neg._sel.)62.45
CD33+_Myeloid104.6
CD34+324.95
CD4+_Tcells75.35
CD56+_NKCells90.9
CD71+_EarlyErythroid27.4
CD8+_Tcells63.8
CardiacMyocytes29.35
Caudatenucleus11
Cerebellum10.15
CerebellumPeduncles12.95
CiliaryGanglion11.4
CingulateCortex10.7
Colorectaladenocarcinoma62.25
DorsalRootGanglion9.35
FetalThyroid45.4
Fetalbrain13.95
Fetalliver23.6
Fetallung26.1
GlobusPallidus8.05
Heart14.2
Hypothalamus19.9
Kidney158.55
Leukemia_chronicMyelogenousK-562225.75
Leukemia_promyelocytic-HL-60326.35
Leukemialymphoblastic(MOLT-4)108.75
Liver36.4
Lung24.2
Lymphnode22.55
Lymphoma_burkitts(Daudi)313.75
Lymphoma_burkitts(Raji)96.1
MedullaOblongata11.05
OccipitalLobe9
OlfactoryBulb10.95
Ovary12.05
Pancreas36.05
PancreaticIslet61.4
ParietalLobe12.95
Pituitary21.05
Placenta28.4
Pons11.6
PrefrontalCortex16.45
Prostate23.8
Salivarygland12.95
SkeletalMuscle12.6
Skin16.85
SmoothMuscle47.95
Spinalcord13.45
SubthalamicNucleus10.8
SuperiorCervicalGanglion13.9
TemporalLobe11.2
Testis11.2
TestisGermCell12.15
TestisIntersitial10.3
TestisLeydigCell11.55
TestisSeminiferousTubule10.5
Thalamus9.85
Thymus47.35
Thyroid115.55
Tongue16.55
Tonsil49
Trachea16.75
TrigeminalGanglion15.3
Uterus10.65
UterusCorpus11.1
WholeBlood28.45
Wholebrain10.4
colon223.9
pineal_day34.44
pineal_night33.58
retina30.025
small_intestine216.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P207360
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.1 ± 0.37
Basal Forebrain5.05 ± 0.46
Basal Part of Pons5.19 ± 0.29
Cerebellar Cortex5.65 ± 0.22
Cerebellar Nuclei5.27 ± 0.37
Claustrum4.5 ± 0.63
Epithalamus5.41 ± 0.33
Frontal Lobe5.18 ± 0.33
Globus Pallidus5.14 ± 0.31
Hypothalamus5.03 ± 0.58
Insula5.37 ± 0.33
Limbic Lobe5.19 ± 0.36
Mesencephalon5.24 ± 0.42
Myelencephalon5.24 ± 0.39
Occipital Lobe5.55 ± 0.35
Parietal Lobe5.28 ± 0.38
Pontine Tegmentum5.17 ± 0.46
Striatum5.16 ± 0.31
Subthalamus5.44 ± 0.06
Temporal Lobe5.15 ± 0.4
Thalamus5.31 ± 0.33
White Matter5.58 ± 0.26
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ak2CBCerebellum13.35
12.36
Ak2CTXCerebral cortex36.05
13.7
Ak2HIPHippocampal region27.65
20
Ak2HPFHippocampal formation25.81
15.22
Ak2HYHypothalamus10.3
3.52
Ak2LSXLateral septal complex15.15
3.83
Ak2MBMidbrain7.8
3.7
Ak2MYMedulla13.94
6.94
Ak2OLFOlfactory bulb32.47
13.99
Ak2PPons12.74
5.62
Ak2PALPallidum11.1
4.13
Ak2RHPRetrohippocampal region23.02
8.88
Ak2sAMYStriatum-like amygdalar nuclei31.56
9.38
Ak2STRStriatum15.44
5.24
Ak2STRdStriatum dorsal region11.68
4.24
Ak2STRvStriatum ventral region21.05
7.05
Ak2THThalamus12.39
4.27
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
KAD2_HUMAN_0 0 0 0 LQAYHTQTTPLIEYYR PRIDE
KAD2_HUMAN_0 0 0 0 LVSDEMVVELIEK PRIDE
KAD2_HUMAN_0 0 0 0 NGFLLDGFPR PRIDE
KAD2_HUMAN_1 16 1 16 APSVPAAEPEYPKGIR PRIDE
KAD2_HUMAN_1 17 1 17 MAPSVPAAEPEYPKGIR PRIDE
KAD2_HUMAN_106 11 106 116 QAEMLDDLMEK PRIDE
KAD2_HUMAN_106 12 106 117 QAEMLDDLMEKR PRIDE
KAD2_HUMAN_119 18 119 136 EKLDSVIEFSIPDSLLIR PRIDE
KAD2_HUMAN_121 16 121 136 LDSVIEFSIPDSLLIR PRIDE
KAD2_HUMAN_121 17 121 137 LDSVIEFSIPDSLLIRR PRIDE
KAD2_HUMAN_150 24 150 173 SYHEEFNPPKEPMKDDITGEPLIR PRIDE
KAD2_HUMAN_17 11 17 27 AVLLGPPGAGK PRIDE
KAD2_HUMAN_17 17 17 33 AVLLGPPGAGKGTQAPR PRIDE
KAD2_HUMAN_176 11 176 186 SDDNEKALKIR PRIDE
KAD2_HUMAN_186 16 186 201 LQAYHTQTTPLIEYYR PRIDE
KAD2_HUMAN_203 26 203 228 RGIHSAIDASQTPDVVFASILAAFSK PRIDE
KAD2_HUMAN_204 25 204 228 GIHSAIDASQTPDVVFASILAAFSK PRIDE
KAD2_HUMAN_34 17 34 50 LAENFCVCHLATGDMLR PRIDE
KAD2_HUMAN_51 12 51 62 AMVASGSELGKK PRIDE
KAD2_HUMAN_72 13 72 84 LVSDEMVVELIEK PRIDE
KAD2_HUMAN_72 21 72 92 LVSDEMVVELIEKNLETPLCK PRIDE
KAD2_HUMAN_85 8 85 92 NLETPLCK PRIDE
KAD2_HUMAN_93 10 93 102 NGFLLDGFPR PRIDE
PAp00004681 17 35 51 LAENFCVCHLATGDMLR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved