AutismKB 2.0

Annotation Detail for EPHB3


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Basic Information Top
Gene Symbol:EPHB3 ( ETK2,HEK2,TYRO6 )
Gene Full Name: EPH receptor B3
Band: 3q27.1
Quick LinksEntrez ID:2049; OMIM: 601839; Uniprot ID:EPHB3_HUMAN; ENSEMBL ID: ENSG00000182580; HGNC ID: 3394
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst4 / 6231964
fetus4 / 5640127
neonate0 / 310970 
infant1 / 2362042
juvenile0 / 555560 
adult56 / 193912128
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor35 / 114246306
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor8 / 26384530
glioma1 / 1068839
head and neck tumor9 / 13630266
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal40 / 336030711
ovarian tumor0 / 766820 
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS9 / 12568071
prostate cancer1 / 1026809
retinoblastoma1 / 4635621
skin tumor1 / 1249498
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood0 / 1234780 
bone3 / 7165541
bone marrow0 / 488010 
brain10 / 11009899
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue8 / 21572237
esophagus0 / 202090 
eye2 / 2110549
heart0 / 896260 
intestine39 / 234472166
kidney2 / 2117779
larynx2 / 2414582
liver0 / 2077430 
lung4 / 33697411
lymph0 / 442700 
lymph node0 / 916100 
mammary gland4 / 15327126
mouth2 / 6705229
muscle0 / 1077150 
nerve0 / 157680 
ovary5 / 10205148
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx3 / 4132872
pituitary gland0 / 165850 
placenta6 / 28082521
prostate1 / 1893455
salivary gland2 / 2015599
skin4 / 21057418
spleen0 / 539520 
stomach3 / 9661931
testis1 / 3304423
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204600_at
Cell line Expression level Expression bar
721_B_lymphoblasts45.3
Adipocyte50.45
AdrenalCortex51.1
Adrenalgland40.9
Amygdala51.3
Appendix48.65
AtrioventricularNode48.9
BDCA4+_DentriticCells32.55
Bonemarrow59.5
BronchialEpithelialCells45.25
CD105+_Endothelial41.55
CD14+_Monocytes51.95
CD19+_BCells(neg._sel.)37.95
CD33+_Myeloid50.25
CD34+49.1
CD4+_Tcells43.8
CD56+_NKCells28.05
CD71+_EarlyErythroid50.1
CD8+_Tcells37.6
CardiacMyocytes63.45
Caudatenucleus48.85
Cerebellum50.35
CerebellumPeduncles61.9
CiliaryGanglion33.85
CingulateCortex54.8
Colorectaladenocarcinoma49.8
DorsalRootGanglion36.35
FetalThyroid51.45
Fetalbrain48.2
Fetalliver50.9
Fetallung42.1
GlobusPallidus35.75
Heart66.65
Hypothalamus51.3
Kidney56.8
Leukemia_chronicMyelogenousK-56252.8
Leukemia_promyelocytic-HL-6042.15
Leukemialymphoblastic(MOLT-4)42.35
Liver73.25
Lung68.3
Lymphnode41.7
Lymphoma_burkitts(Daudi)68.95
Lymphoma_burkitts(Raji)68.85
MedullaOblongata44.55
OccipitalLobe43.4
OlfactoryBulb43
Ovary36.8
Pancreas56.1
PancreaticIslet61.3
ParietalLobe62.05
Pituitary59.45
Placenta48.7
Pons46.4
PrefrontalCortex49.4
Prostate107.15
Salivarygland42.85
SkeletalMuscle60
Skin38.2
SmoothMuscle52.1
Spinalcord79.05
SubthalamicNucleus46.35
SuperiorCervicalGanglion52.85
TemporalLobe49.25
Testis50.3
TestisGermCell39.9
TestisIntersitial36.55
TestisLeydigCell49
TestisSeminiferousTubule42.4
Thalamus62.1
Thymus40.4
Thyroid60.65
Tongue70.4
Tonsil47.85
Trachea68.9
TrigeminalGanglion65.45
Uterus66.5
UterusCorpus45.1
WholeBlood49.95
Wholebrain42.85
colon48.35
pineal_day51.2
pineal_night51.36
retina56.05
small_intestine46.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_8507_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.47 ± 1.03
Basal Forebrain2.01 ± 0.59
Basal Part of Pons3.01 ± 0.69
Cerebellar Cortex2.9 ± 0.46
Cerebellar Nuclei2.36 ± 0.71
Claustrum2.94 ± 1.11
Epithalamus2.43 ± 0.61
Frontal Lobe2.45 ± 0.71
Globus Pallidus2.37 ± 0.66
Hypothalamus1.97 ± 0.5
Insula2.35 ± 0.71
Limbic Lobe2.49 ± 0.66
Mesencephalon2.42 ± 0.73
Myelencephalon2.43 ± 0.72
Occipital Lobe2.71 ± 0.81
Parietal Lobe2.43 ± 0.72
Pontine Tegmentum2.35 ± 0.8
Striatum1.72 ± 0.64
Subthalamus2.2 ± 0.85
Temporal Lobe2.29 ± 0.75
Thalamus2.72 ± 0.63
White Matter2.16 ± 0.35
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ephb3CBCerebellum7.34
4.88
Ephb3CTXCerebral cortex7.71
4.31
Ephb3HIPHippocampal region7.29
4.49
Ephb3HPFHippocampal formation6.14
3.64
Ephb3HYHypothalamus2.65
1.59
Ephb3LSXLateral septal complex0.87
0.45
Ephb3MBMidbrain5.16
4.19
Ephb3MYMedulla5.48
3.94
Ephb3OLFOlfactory bulb6.09
3.5
Ephb3PPons5.65
4.5
Ephb3PALPallidum0.49
0.25
Ephb3RHPRetrohippocampal region3.11
2
Ephb3sAMYStriatum-like amygdalar nuclei0.5
0.34
Ephb3STRStriatum0.56
0.34
Ephb3STRdStriatum dorsal region0.44
0.29
Ephb3STRvStriatum ventral region0.76
0.32
Ephb3THThalamus2.69
1.66
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00096602 11 763 773 NILVNSNLVCK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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