AutismKB 2.0

Annotation Detail for EPHB6


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Basic Information Top
Gene Symbol:EPHB6 ( HEP,MGC129910,MGC129911 )
Gene Full Name: EPH receptor B6
Band: 7q34
Quick LinksEntrez ID:2051; OMIM: 602757; Uniprot ID:EPHB6_HUMAN; ENSEMBL ID: ENSG00000106123; HGNC ID: 3396
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst4 / 6231964
fetus11 / 56401219
neonate0 / 310970 
infant5 / 23620211
juvenile1 / 5555617
adult48 / 193912124
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia3 / 9584231
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal90 / 336030726
ovarian tumor1 / 7668213
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder2 / 2975767
blood3 / 12347824
bone1 / 7165513
bone marrow0 / 488010 
brain40 / 110098936
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue6 / 21572227
esophagus0 / 202090 
eye6 / 21105428
heart2 / 8962622
intestine0 / 2344720 
kidney2 / 2117779
larynx0 / 241450 
liver1 / 2077434
lung1 / 3369742
lymph0 / 442700 
lymph node1 / 9161010
mammary gland2 / 15327113
mouth0 / 670520 
muscle1 / 1077159
nerve1 / 1576863
ovary2 / 10205119
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate5 / 18934526
salivary gland0 / 201550 
skin14 / 21057466
spleen0 / 539520 
stomach0 / 966190 
testis6 / 33044218
thymus3 / 8113136
thyroid0 / 474730 
tonsil2 / 16999117
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204718_at
Cell line Expression level Expression bar
721_B_lymphoblasts13.85
Adipocyte23.5
AdrenalCortex25.5
Adrenalgland10.5
Amygdala73.8
Appendix19.55
AtrioventricularNode20.3
BDCA4+_DentriticCells16.7
Bonemarrow26.05
BronchialEpithelialCells24.55
CD105+_Endothelial20.75
CD14+_Monocytes34.3
CD19+_BCells(neg._sel.)50.55
CD33+_Myeloid33.75
CD34+35.7
CD4+_Tcells48.95
CD56+_NKCells15.55
CD71+_EarlyErythroid9.75
CD8+_Tcells29.1
CardiacMyocytes26
Caudatenucleus300.9
Cerebellum19.1
CerebellumPeduncles26.95
CiliaryGanglion19.2
CingulateCortex227.45
Colorectaladenocarcinoma176.7
DorsalRootGanglion19.25
FetalThyroid28
Fetalbrain200.9
Fetalliver17.6
Fetallung15.15
GlobusPallidus182.65
Heart35.9
Hypothalamus24.05
Kidney20.35
Leukemia_chronicMyelogenousK-562348.7
Leukemia_promyelocytic-HL-6014.75
Leukemialymphoblastic(MOLT-4)457.75
Liver31.05
Lung27.55
Lymphnode33.65
Lymphoma_burkitts(Daudi)31.35
Lymphoma_burkitts(Raji)33.75
MedullaOblongata319.3
OccipitalLobe189.2
OlfactoryBulb18
Ovary20
Pancreas24.95
PancreaticIslet27.5
ParietalLobe222.6
Pituitary27.35
Placenta32.75
Pons137.75
PrefrontalCortex849.2
Prostate93.5
Salivarygland24.05
SkeletalMuscle35.85
Skin68.15
SmoothMuscle11.75
Spinalcord28.85
SubthalamicNucleus290
SuperiorCervicalGanglion32.55
TemporalLobe222.05
Testis26.95
TestisGermCell33.7
TestisIntersitial23.1
TestisLeydigCell26.05
TestisSeminiferousTubule25.55
Thalamus51.5
Thymus405.6
Thyroid78.15
Tongue31.05
Tonsil40.65
Trachea16.65
TrigeminalGanglion33.15
Uterus30.45
UterusCorpus31.15
WholeBlood30.2
Wholebrain460.65
colon35.45
pineal_day105.62
pineal_night71.48
retina32.075
small_intestine29.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14973_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.43 ± 0.71
Basal Forebrain6.55 ± 0.61
Basal Part of Pons7.4 ± 0.59
Cerebellar Cortex5.57 ± 0.52
Cerebellar Nuclei5.12 ± 0.78
Claustrum6.45 ± 1.29
Epithalamus5.81 ± 0.98
Frontal Lobe6.97 ± 0.74
Globus Pallidus4.67 ± 1.48
Hypothalamus6.89 ± 0.59
Insula6.64 ± 0.4
Limbic Lobe6.11 ± 1.01
Mesencephalon6.25 ± 0.75
Myelencephalon6.37 ± 0.95
Occipital Lobe5.76 ± 0.95
Parietal Lobe6.83 ± 0.8
Pontine Tegmentum6.2 ± 0.82
Striatum7.09 ± 0.98
Subthalamus5.92 ± 0.45
Temporal Lobe6.67 ± 0.74
Thalamus6.35 ± 0.73
White Matter4.35 ± 1.23
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ephb6CBCerebellum14.88
13.6
Ephb6CTXCerebral cortex85.98
77.03
Ephb6HIPHippocampal region50.6
44.75
Ephb6HPFHippocampal formation60.73
48.41
Ephb6HYHypothalamus32.16
19.56
Ephb6LSXLateral septal complex28.9
14.15
Ephb6MBMidbrain32.36
22.44
Ephb6MYMedulla31.86
24.65
Ephb6OLFOlfactory bulb44.62
26.22
Ephb6PPons31.13
23.72
Ephb6PALPallidum28.12
20.06
Ephb6RHPRetrohippocampal region66.52
52.56
Ephb6sAMYStriatum-like amygdalar nuclei31.5
18.18
Ephb6STRStriatum38.49
20.65
Ephb6STRdStriatum dorsal region42.88
23.81
Ephb6STRvStriatum ventral region32.21
14.12
Ephb6THThalamus31.87
19.84
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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