AutismKB 2.0

Annotation Detail for EPHX1


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Basic Information Top
Gene Symbol:EPHX1 ( EPHX,EPOX,MEH )
Gene Full Name: epoxide hydrolase 1, microsomal (xenobiotic)
Band: 1q42.12
Quick LinksEntrez ID:2052; OMIM: 132810; Uniprot ID:HYEP_HUMAN; ENSEMBL ID: ENSG00000143819; HGNC ID: 3401
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst5 / 6231980
fetus15 / 56401226
neonate0 / 310970 
infant1 / 2362042
juvenile1 / 5555617
adult175 / 193912190
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor6 / 12794468
bladder carcinoma1 / 1747557
breast (mammary gland) tumor4 / 9417842
cervical tumor2 / 3436658
chondrosarcoma16 / 82823193
colorectal tumor8 / 11424670
esophageal tumor0 / 172900 
gastrointestinal tumor5 / 11936941
germ cell tumor5 / 26384518
glioma11 / 106883102
head and neck tumor8 / 13630258
kidney tumor7 / 68959101
leukemia4 / 9584241
liver tumor8 / 9635983
lung tumor44 / 103127426
lymphoma0 / 717550 
non-neoplasia6 / 9725061
normal214 / 336030763
ovarian tumor13 / 76682169
pancreatic tumor15 / 104616143
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer12 / 102680116
retinoblastoma5 / 46356107
skin tumor18 / 124949144
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor18 / 90257199
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue4 / 13106305
adrenal gland20 / 33197602
ascites0 / 400150 
bladder1 / 2975733
blood5 / 12347840
bone8 / 71655111
bone marrow0 / 488010 
brain70 / 110098963
cervix3 / 4817162
connective tissue13 / 14925587
ear0 / 162120 
embryonic tissue9 / 21572241
esophagus0 / 202090 
eye33 / 211054156
heart3 / 8962633
intestine15 / 23447263
kidney9 / 21177742
larynx0 / 241450 
liver17 / 20774381
lung79 / 336974234
lymph0 / 442700 
lymph node0 / 916100 
mammary gland10 / 15327165
mouth1 / 6705214
muscle6 / 10771555
nerve1 / 1576863
ovary16 / 102051156
pancreas25 / 214812116
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta12 / 28082542
prostate18 / 18934595
salivary gland9 / 20155446
skin22 / 210574104
spleen4 / 5395274
stomach3 / 9661931
testis8 / 33044224
thymus5 / 8113161
thyroid0 / 474730 
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus18 / 23287877
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202017_at
Cell line Expression level Expression bar
721_B_lymphoblasts11.75
Adipocyte1675
AdrenalCortex1553.25
Adrenalgland4259.7
Amygdala265.1
Appendix156
AtrioventricularNode111.5
BDCA4+_DentriticCells5.75
Bonemarrow35
BronchialEpithelialCells35.7
CD105+_Endothelial76.2
CD14+_Monocytes37.75
CD19+_BCells(neg._sel.)4.85
CD33+_Myeloid35.65
CD34+11
CD4+_Tcells9.1
CD56+_NKCells5.85
CD71+_EarlyErythroid5.9
CD8+_Tcells4.3
CardiacMyocytes90.2
Caudatenucleus187.2
Cerebellum98.3
CerebellumPeduncles113.4
CiliaryGanglion123.45
CingulateCortex127.3
Colorectaladenocarcinoma212.7
DorsalRootGanglion95
FetalThyroid219.05
Fetalbrain39.85
Fetalliver413.4
Fetallung125.7
GlobusPallidus81.1
Heart278.55
Hypothalamus151.85
Kidney326.7
Leukemia_chronicMyelogenousK-56213.5
Leukemia_promyelocytic-HL-6015.25
Leukemialymphoblastic(MOLT-4)15.55
Liver7077.55
Lung1075.6
Lymphnode147.6
Lymphoma_burkitts(Daudi)13.75
Lymphoma_burkitts(Raji)25.25
MedullaOblongata128.5
OccipitalLobe123.8
OlfactoryBulb365.95
Ovary200.5
Pancreas100.45
PancreaticIslet174
ParietalLobe128.65
Pituitary170.85
Placenta76.1
Pons130
PrefrontalCortex606.8
Prostate282.5
Salivarygland79.45
SkeletalMuscle122
Skin57.75
SmoothMuscle35.9
Spinalcord267.5
SubthalamicNucleus58.45
SuperiorCervicalGanglion156.5
TemporalLobe82.95
Testis194.8
TestisGermCell198.1
TestisIntersitial158.35
TestisLeydigCell180.85
TestisSeminiferousTubule157.05
Thalamus266.35
Thymus93.95
Thyroid777.3
Tongue127.05
Tonsil64.15
Trachea230.15
TrigeminalGanglion170.25
Uterus263.8
UterusCorpus108.3
WholeBlood17
Wholebrain162.75
colon113.05
pineal_day733.4
pineal_night498.72
retina501.8
small_intestine150.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15680_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.89 ± 0.44
Basal Forebrain5.08 ± 0.15
Basal Part of Pons5.43 ± 0.38
Cerebellar Cortex4.85 ± 0.31
Cerebellar Nuclei5.11 ± 0.49
Claustrum4.18 ± 0.43
Epithalamus5.6 ± 0.6
Frontal Lobe5.22 ± 0.47
Globus Pallidus6.25 ± 0.37
Hypothalamus5 ± 0.38
Insula5.23 ± 0.35
Limbic Lobe5.24 ± 0.46
Mesencephalon5.34 ± 0.4
Myelencephalon5.26 ± 0.54
Occipital Lobe5.03 ± 0.49
Parietal Lobe5.15 ± 0.48
Pontine Tegmentum5.24 ± 0.57
Striatum5.81 ± 0.43
Subthalamus4.74 ± 0.34
Temporal Lobe5.27 ± 0.41
Thalamus5.64 ± 0.46
White Matter6.03 ± 0.3
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ephx1CBCerebellum14.3
16.15
Ephx1CTXCerebral cortex22.95
17.52
Ephx1HIPHippocampal region22.98
32.59
Ephx1HPFHippocampal formation21.97
25.53
Ephx1HYHypothalamus10.28
10.14
Ephx1LSXLateral septal complex15.31
14.38
Ephx1MBMidbrain7.75
10.46
Ephx1MYMedulla17.37
23.63
Ephx1OLFOlfactory bulb22.44
18.09
Ephx1PPons14.06
19.41
Ephx1PALPallidum7.3
5.98
Ephx1RHPRetrohippocampal region20.46
16.34
Ephx1sAMYStriatum-like amygdalar nuclei25.83
19.19
Ephx1STRStriatum23.71
16.32
Ephx1STRdStriatum dorsal region24.93
16.41
Ephx1STRvStriatum ventral region23.39
15.26
Ephx1THThalamus8.5
12.56
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
HYEP_HUMAN_428 18 428 445 GGHFAAFEEPELLAQDIR PRIDE
HYEP_HUMAN_58 9 58 66 EEIHDLHQR PRIDE
PAp00002231 33 296 328 ESGYMHIQCTKPDTVGSALNDSPVGLAAYILEK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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