Annotation Detail for ERBB4
Basic Information Top
| Gene Symbol: | ERBB4 ( HER4,MGC138404,p180erbB4 ) |
|---|---|
| Gene Full Name: | v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) |
| Band: | 2q34 |
| Quick Links | Entrez ID:2066; OMIM: 600543; Uniprot ID:ERBB4_HUMAN; ENSEMBL ID: ENSG00000178568; HGNC ID: 3432 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.390729
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 2 / 70761 | 28 |  |
| blastocyst | 0 / 62319 | 0 | |
| fetus | 7 / 564012 | 12 | |
| neonate | 0 / 31097 | 0 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 0 / 55556 | 0 | |
| adult | 32 / 1939121 | 16 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 1 / 94178 | 10 |  |
| cervical tumor | 0 / 34366 | 0 | |
| chondrosarcoma | 1 / 82823 | 12 | |
| colorectal tumor | 0 / 114246 | 0 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 0 / 119369 | 0 | |
| germ cell tumor | 2 / 263845 | 7 | |
| glioma | 1 / 106883 | 9 | |
| head and neck tumor | 1 / 136302 | 7 | |
| kidney tumor | 0 / 68959 | 0 | |
| leukemia | 0 / 95842 | 0 | |
| liver tumor | 0 / 96359 | 0 | |
| lung tumor | 0 / 103127 | 0 | |
| lymphoma | 0 / 71755 | 0 | |
| non-neoplasia | 1 / 97250 | 10 | |
| normal | 58 / 3360307 | 17 | |
| ovarian tumor | 0 / 76682 | 0 | |
| pancreatic tumor | 0 / 104616 | 0 | |
| primitive neuroectodermal tumor of the CNS | 0 / 125680 | 0 | |
| prostate cancer | 0 / 102680 | 0 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 0 / 124949 | 0 | |
| soft tissue/muscle tissue tumor | 0 / 125191 | 0 | |
| uterine tumor | 3 / 90257 | 33 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 0 / 29757 | 0 | |
| blood | 0 / 123478 | 0 | |
| bone | 0 / 71655 | 0 | |
| bone marrow | 0 / 48801 | 0 | |
| brain | 18 / 1100989 | 16 | |
| cervix | 0 / 48171 | 0 | |
| connective tissue | 1 / 149255 | 6 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 3 / 215722 | 13 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 0 / 211054 | 0 | |
| heart | 3 / 89626 | 33 | |
| intestine | 0 / 234472 | 0 | |
| kidney | 6 / 211777 | 28 | |
| larynx | 1 / 24145 | 41 | |
| liver | 0 / 207743 | 0 | |
| lung | 4 / 336974 | 11 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 0 / 91610 | 0 | |
| mammary gland | 5 / 153271 | 32 | |
| mouth | 0 / 67052 | 0 | |
| muscle | 7 / 107715 | 64 |  |
| nerve | 0 / 15768 | 0 | |
| ovary | 1 / 102051 | 9 | |
| pancreas | 1 / 214812 | 4 | |
| parathyroid | 5 / 20539 | 243 |  |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 0 / 280825 | 0 | |
| prostate | 0 / 189345 | 0 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 0 / 210574 | 0 | |
| spleen | 0 / 53952 | 0 | |
| stomach | 0 / 96619 | 0 | |
| testis | 5 / 330442 | 15 | |
| thymus | 0 / 81131 | 0 | |
| thyroid | 1 / 47473 | 21 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 4 / 52413 | 76 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 3 / 232878 | 12 | |
| vascular | 0 / 51780 | 0 |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 214053_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 5.5 | |
| Adipocyte | 4.55 | |
| AdrenalCortex | 4.95 | |
| Adrenalgland | 4 | |
| Amygdala | 63.9 | |
| Appendix | 14.95 | |
| AtrioventricularNode | 4.25 | |
| BDCA4+_DentriticCells | 4.85 | |
| Bonemarrow | 4.8 | |
| BronchialEpithelialCells | 4.45 | |
| CD105+_Endothelial | 4.75 | |
| CD14+_Monocytes | 4.95 | |
| CD19+_BCells(neg._sel.) | 4.8 | |
| CD33+_Myeloid | 6.15 | |
| CD34+ | 5.65 | |
| CD4+_Tcells | 5 | |
| CD56+_NKCells | 5.3 | |
| CD71+_EarlyErythroid | 4.5 | |
| CD8+_Tcells | 4.5 | |
| CardiacMyocytes | 6.5 | |
| Caudatenucleus | 48.5 | |
| Cerebellum | 6.35 | |
| CerebellumPeduncles | 5.7 | |
| CiliaryGanglion | 3.7 | |
| CingulateCortex | 25.85 | |
| Colorectaladenocarcinoma | 4.8 | |
| DorsalRootGanglion | 4 | |
| FetalThyroid | 4.65 | |
| Fetalbrain | 137.5 | |
| Fetalliver | 4.15 | |
| Fetallung | 3.8 | |
| GlobusPallidus | 24.75 | |
| Heart | 6.05 | |
| Hypothalamus | 33.35 | |
| Kidney | 4.05 | |
| Leukemia_chronicMyelogenousK-562 | 4.3 | |
| Leukemia_promyelocytic-HL-60 | 4.15 | |
| Leukemialymphoblastic(MOLT-4) | 3.7 | |
| Liver | 6.3 | |
| Lung | 5.25 | |
| Lymphnode | 4.15 | |
| Lymphoma_burkitts(Daudi) | 6.1 | |
| Lymphoma_burkitts(Raji) | 6.6 | |
| MedullaOblongata | 24.1 | |
| OccipitalLobe | 48.65 | |
| OlfactoryBulb | 7.8 | |
| Ovary | 3.25 | |
| Pancreas | 3.85 | |
| PancreaticIslet | 5.05 | |
| ParietalLobe | 27.3 | |
| Pituitary | 14.5 | |
| Placenta | 4.9 | |
| Pons | 12.05 | |
| PrefrontalCortex | 63.5 | |
| Prostate | 5.5 | |
| Salivarygland | 4.3 | |
| SkeletalMuscle | 5.4 | |
| Skin | 3.9 | |
| SmoothMuscle | 5.2 | |
| Spinalcord | 13.65 | |
| SubthalamicNucleus | 24.65 | |
| SuperiorCervicalGanglion | 25.95 | |
| TemporalLobe | 7.5 | |
| Testis | 4.25 | |
| TestisGermCell | 18.45 | |
| TestisIntersitial | 4.05 | |
| TestisLeydigCell | 5.05 | |
| TestisSeminiferousTubule | 5.1 | |
| Thalamus | 5.7 | |
| Thymus | 3.55 | |
| Thyroid | 6.25 | |
| Tongue | 4.7 | |
| Tonsil | 4.6 | |
| Trachea | 4.2 | |
| TrigeminalGanglion | 5.1 | |
| Uterus | 3.85 | |
| UterusCorpus | 4.3 | |
| WholeBlood | 5.1 | |
| Wholebrain | 31.9 | |
| colon | 4.75 | |
| pineal_day | 309.58 | |
| pineal_night | 271.46 | |
| retina | 12.15 | |
| small_intestine | 4.45 | |
- Probe name: CUST_251_PI416408490
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 7.37 ± 0.46 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 7.14 ± 0.23 | |
| Basal Part of Pons | 6.73 ± 0.43 | |
| Cerebellar Cortex | 6.27 ± 0.58 | |
| Cerebellar Nuclei | 6.81 ± 0.41 | |
| Claustrum | 6.77 ± 0.57 | |
| Epithalamus | 6.81 ± 0.48 | |
| Frontal Lobe | 6.65 ± 0.58 | |
| Globus Pallidus | 7.13 ± 0.29 | |
| Hypothalamus | 7.02 ± 0.62 | |
| Insula | 6.86 ± 0.65 | |
| Limbic Lobe | 6.66 ± 0.62 | |
| Mesencephalon | 7.03 ± 0.71 | |
| Myelencephalon | 6.73 ± 0.56 | |
| Occipital Lobe | 6.42 ± 0.42 | |
| Parietal Lobe | 6.82 ± 0.57 | |
| Pontine Tegmentum | 6.77 ± 0.51 | |
| Striatum | 7.3 ± 0.47 | |
| Subthalamus | 6.75 ± 0.27 | |
| Temporal Lobe | 6.71 ± 0.51 | |
| Thalamus | 6.54 ± 0.46 | |
| White Matter | 6.85 ± 0.54 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Erbb4 | CB | Cerebellum | 13.72 | |
| 16.26 | | |||
| Erbb4 | CTX | Cerebral cortex | 57.63 | |
| 85.12 | | |||
| Erbb4 | HIP | Hippocampal region | 32.63 | |
| 65.77 | | |||
| Erbb4 | HPF | Hippocampal formation | 43.85 | |
| 75.37 | | |||
| Erbb4 | HY | Hypothalamus | 74.69 | |
| 81.25 | | |||
| Erbb4 | LSX | Lateral septal complex | 76.81 | |
| 85.88 | | |||
| Erbb4 | MB | Midbrain | 54.1 | |
| 59.43 | | |||
| Erbb4 | MY | Medulla | 41.64 | |
| 51.15 | | |||
| Erbb4 | OLF | Olfactory bulb | 82.8 | |
| 95.47 | | |||
| Erbb4 | P | Pons | 51.03 | |
| 60.79 | | |||
| Erbb4 | PAL | Pallidum | 68.91 | |
| 82.97 | | |||
| Erbb4 | RHP | Retrohippocampal region | 61.28 | |
| 87.11 | | |||
| Erbb4 | sAMY | Striatum-like amygdalar nuclei | 85.74 | |
| 99.87 | | |||
| Erbb4 | STR | Striatum | 54.62 | |
| 61.1 | | |||
| Erbb4 | STRd | Striatum dorsal region | 38.13 | |
| 41.96 | | |||
| Erbb4 | STRv | Striatum ventral region | 77.92 | |
| 82.63 | | |||
| Erbb4 | TH | Thalamus | 23.9 | |
| 27.04 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| PAp00397509 | 12 | 723 | 734 | VLGSGAFGTVYK | Peptide Atlas |